What Does a Clinician-Scientist Do?

Wang Ningli, male, chief physician, professor, doctoral supervisor, Beijing scholar, academician of the International Academy of Ophthalmology.

Wang Ningli

Wang Ningli, male, chief physician, professor, doctoral supervisor, Beijing scholar, academician of the International Academy of Ophthalmology.

He is currently the president of Beijing Tongren Hospital, deputy secretary of the party committee, director of the ophthalmology center, director of the Beijing Eye Research Institute, and dean of the School of Ophthalmology, Capital Medical University. Former Chairman of the Ophthalmology Branch of the Chinese Medical Association, Chairman of the Ophthalmology Branch of the Chinese Medical Association, Editor-in-Chief of the Chinese Journal of Ophthalmology; Academician of the International Academy of Ophthalmology, Executive Director of the World Federation of Glaucoma Associations, Executive Director of the International Ophthalmological Association, Asia Pacific Ophthalmology Vice Chairman, Deputy Editor-in-Chief of the Asia-Pacific Journal of Ophthalmology. The Ministry of Health has made outstanding contributions to young and middle-aged experts and enjoyed special allowances from the State Council. In 2015 won the honorary title of National Advanced Worker.

He has been engaged in clinical and scientific research in ophthalmology for more than 30 years, focusing on glaucoma clinical and scientific research and ophthalmic prevention. He is currently the chief ophthalmologist and central health consultation expert of Beijing Tongren Hospital, and is one of the most complete experts in ophthalmology and glaucoma surgery in China. Developed, established, and promoted 9 new clinical technologies, established the Beijing Key Laboratory of Ophthalmology and Visual Sciences and the National Research Center for Ophthalmic Diagnostic and Therapeutic Equipment Engineering Technology; and set up a "Beijing Scholar" innovation team. On the basis of the above platform, scientific research and research and development are aimed at urgent problems in the clinical field of ophthalmology.

In 2014 and 2016, he was named one of the 100 most influential ophthalmologists in the world by The Ophthalmologists magazine. He has won two National Science and Technology Progress Awards, two World Clinical Glaucoma Society "Clinical Scientist" Awards, Chinese Physician Awards, Zhou Guangzhao "Clinic Physician Awards", and National Advanced Science and Technology Workers. In 2013, the first batch was selected into the "Beijing Scholars" program.

In May 2017, it won the National Innovation Leadership Award. ^[1]

1. In 2016, it was rated as one of the 100 most influential ophthalmologists in the world by "The Ophthalmologists" magazine; in April 2016, he was the vice chairman of the Asia-Pacific Academy of Ophthalmology; in December 2016, the National Health and Family Planning Commission was awarded the development of China's medical and health services Foundation, "People's Good Doctor" title of Chinese Medical Association. In 2016, it won the honorary title of Beijing has outstanding contributions in science, technology and management talents.

2. In 2015, it won the honorary title of National Advanced Worker and was selected into the Outstanding Talents of Beijing High-level Innovation and Entrepreneurship Talent Program.

3. In 2015, he won the honorary title of National Advanced Worker and was selected into the "Outstanding Talents of Beijing High-level Innovation and Entrepreneurship Talent Program".

4. In 2014 won the second prize of National Science and Technology Progress: "The establishment and application of new prevention and treatment technology for primary open-angle glaucoma" Primary open-angle glaucoma (commonly known as "open glaucoma") is the world's first irreversible blindness Sexual eye disease. The blindness rate in China is 15% -30%, which is much higher than the average level of 8% in developed countries. Aiming at the above problems, this research takes the key technology and equipment to solve the problem of screening and monitoring as a breakthrough. In China, firstly created and implemented a screening mode based on digital and network technologies: through two large-scale investigations, The risk factors and people at risk in our country. Based on the study of the anatomical parameters of the fundus optic disc and the optic nerve fiber layer, a green screening technique and standard based on digital fundus photography technology was established. The use of remote network technology has effectively integrated tertiary medical resources, and for the first time realized the transition of Kaiqing's model from treatment to community prevention and control, increasing the population's youth detection rate from 10% to 95%.

5. In 2014, he won the honorary title of National Outstanding Scientific and Technological Worker, was awarded the "Clinician Award" of Zhou Guangzhao Foundation, was elected a member of the International Academy of Ophthalmology, and was named as the 100 most influential ophthalmologists in the world by the American "Ophthalmologist" magazine.

6. In 2013, he won the second prize of National Scientific and Technological Progress: "The establishment and application of the pathogenesis and prevention system of primary angle-closure glaucoma" Primary angle-closure glaucoma (referred to as "closed blue") is the most common in China and even in Asia. Common irreversible blindness causes 10.1 million patients in China. The research started with answering the scientific questions about the pathogenesis of autism, and established a new technical system for prevention and treatment of autism with breakthroughs in key technologies and equipment. Based on the mechanism theory and classification system and new screening and diagnosis technologies, a diagnosis and treatment model suitable for primary and secondary hospitals has been established, which has reduced the early intervention intervention rate by 40%. A salvage treatment route for the acute onset of closure was designed and clinically promoted in China, which reduced the blinding rate of emergency closure by 70%. Evidence-based evaluation of the traditional indications for closed green surgery, and the establishment of a sequential treatment model of drugs, lasers, and surgery, reducing the surgical rate from 80% to 14%. The project has been promoted and applied in 22 provinces and cities, covering 130 million people, benefiting about 1 million people with autism, and reducing the blinding rate from 37.5% -75% to 4% -11.6%. The project has completed the leap from technology tracking to technology leadership in China's closed youth prevention and control technology.

7. Selected as "Beijing Scholar" in 2013 and won the Chinese Apple Ophthalmology Golden Apple Award

8. The first prize of the 2012 Chinese Medical Science and Technology Award: "The establishment and application of the mechanism classification of primary open-angle glaucoma and the new diagnosis and treatment model"

9. The first prize of the 2011 Chinese Medical Science and Technology Award: "Preventive Technology and Promotion of Primary Angle Closed Glaucoma"

10. The first prize of the Natural Science Award of the Ministry of Education in 2009: "Study on the mechanism of cytoskeleton and extracellular matrix in the regulation of intraocular pressure"

11. First Prize of Natural Science Award of Chinese University in 2001 (Natural Science Award of the Ministry of Education): "A Series of Studies on the Pathogenesis and Classification of Primary Angle-closure Glaucoma in China"

1. Study on the mechanism of the pressure difference across the sieve plate in the optic nerve damage in glaucoma caused by different causes (funded by the National Natural Science Foundation of China)

2. Key technologies and engineering research of coherent optical tomography scanners for comprehensive imaging of ophthalmic functions and structures (National Science and Technology Support Program)

3. A cohort study of risk factors for myopia among school-age children in China and Australia (funded by the National Natural Science Foundation of China)

4. Study on the molecular mechanism of multigenic pathogenicity of primary open-angle glaucoma (funded by the National Natural Science Foundation of China)

5. Basic research on the influence of environmental factors on the processing and processing of visual information abnormalities related to the occurrence of myopia and intervention (National Key Basic Research Development Plan '973 Plan')

6. R & D of ophthalmic diagnosis and treatment technology and equipment (National Science and Technology Support Plan)

7. Construction of technology platform for clinical evaluation and research of new drugs for eye diseases (12th Five-year Project)

8. Human embryonic development of melanin-containing retinal ganglion cells (funded by the National Natural Science Foundation of China)

9. Research on the manufacturing technology and equipment of implantable personalized human eye high-order aberration correction lenses (National High-Tech Research and Development Program '863 Plan')

10. Experimental study on the effects of high intraocular pressure on the structure and function of retinal ganglion cells expressing melanin (funded by the National Natural Science Foundation of China)

* Yang, Diya; Fu, Jidi; Hou, Ruowu; Liu, Kegao; Jonas, Jost B .; Wang, Huaizhou; Chen, Weiwei; Li, Zhen; Sang, Jinghong; Zhang, Zheng; Liu, Sumeng; Cao, Yiwen ; Xie, Xiaobin; Ren, Ruojin; Lu, Qingjun ..., Author Response: Optic Neuropathy Secondary to Spontaneous Intracranial Hypotension (SIH) as Related to Experimental Primate Model, Investigative Ophthalmology & Visual Science, 55 (10), p 6177, 2014 / 10.

Zhang, Zheng; Wang, Xiaolei; Jonas, Jost B .; Wang, Huaizhou; Zhang, Xiaojun; Peng, Xiaoxia; Ritch, Robert; Tian, Guohong; Yang, Diya; Li, Lei; * Li, Junfa; Wang, Ningli , Valsalva manoeuver, intra-ocular pressure, cerebrospinal fluid pressure, optic disc topography: Beijing intracranial and intra-ocular pressure study, Acta Ophthalmologica, 92 (6), pp E475-E480, 2014/9.

Hong, Jie; Zhang, Hui; Kuo, Debbie S .; Wang, Huaizhou; Huo, Yanjiao; Yang, Diya; * Wang, Ningli , The Short-Term Effects of Exercise on Intraocular Pressure, Choroidal Thickness and Axial Length, PLos One , 9 (8), 2014/8/29.

Zhang, Ye; Li, Si Zhen; Li, Lei; Thomas, Ravi; * Wang, Ning Li , The Handan Eye Study: Comparison of Screening Methods for Primary Angle Closure Suspects in a Rural Chinese Population, Ophthalmic Epidemiology, 21 (4) , pp 268-275, 2014/8.

Yang, Diya; Fu, Jidi; Hou, Ruowu; Liu, Kegao; Jonas, Jost B .; Wang, Huaizhou; Chen, Weiwei; Li, Zhen; Sang, Jinghong; Zhang, Zheng; Liu, Sumeng; Cao, Yiwen; Xie, Xiaobin; Ren, Ruojin; Lu, Qingjun ..., Glaucoma Considered as an Imbalance Between Production and Clearance of Neurotoxins, Investigative Ophthalmology & Visual Science, 55 (8), p 5353, 2014/8.

Zhang, Ye; Li, Si Zhen; Li, Lei; He, Ming Guang; Thomas, Ravi; * Wang, Ning Li , Quantitative Analysis of Iris Changes After Physiologic and Pharmacologic Mydriasis in a Rural Chinese Population, Investigative Ophthalmology & Visual Science, 55 (7), pp 4405-4412, 2014/7.

Liu, Kegao; * Wang, Ningli ; Peng, Xiaoyan; Yang, Diya; Wang, Cong; Zeng, Huiyang, Long-Term Effect of Laser-Induced Ocular Hypertension on the Cone Electroretinogram and Central Macular Thickness in Monkeys, Photomedicine and Laser Surgery , 32 (7), pp 371-378, 2014/7.

Fu, Jing; Li, Shi Ming; Liu, Luo Ru; Li, Jin Ling; Li, Si Yuan; Zhu, Bi Dan; Li, He; Yang, Zhou; Li, Lei; * Wang, Ning Li , Prevalence of Amblyopia and Strabismus in a Population of 7th-Grade Junior High School Students in Central China: The Anyang Childhood Eye Study (ACES), Ophthalmic Epidemiology, 21 (3), pp 197-203, 2014/6.

Zhang Qing; Li Sizhen; Liang Yuanbo; Wang Fenghua; Chen Weiwei; * Wang Ningli , Characteristics of optic disc parameters and its association in normal Chinese population: the Handan Eye Study, Chinese Medical Journal, 127 (9), pp 1702-1709 , 5/5/2014.

* Jonas, Jost B .; Wang, Ningli ; Xu, Jie; Wang, Ya Xing; You, Qi Sheng; Yang, Diya; Bin Xie, Xiao; Xu, Liang, Diabetic Retinopathy and Estimated Cerebrospinal Fluid Pressure. The Beijing Eye Study 2011, PLos One, 9 (5), 2014/5/1.

Yang, Diya; Fu, Jidi; Hou, Ruowu; Liu, Kegao; Jonas, Jost B .; Wang, Huaizhou; Chen, Weiwei; Li, Zhen; Sang, Jinghong; Zhang, Zheng; Liu, Sumeng; Cao, Yiwen; Xie, Xiaobin; Ren, Ruojin; Lu, Qingjun ..., Optic Neuropathy Induced by Experimentally Reduced Cerebrospinal Fluid Pressure in Monkeys, Investigative Ophthalmology & Visual Science, 55 (5), pp 3067-3073, 2014/5.

* Nongpiur, Monisha E .; Khor, Chiea Chuen; Jia, Hongyan; Cornes, Belinda K .; Chen, Li-Jia; Qiao, Chunyan; Nair, K. Saidas; Cheng, Ching-Yu; Xu, Liang; George, Ronnie; Do, Tan; Abu-Amero, Khaled ..., ABCC5, a Gene That Influences the Anterior Chamber Depth, Is Associated with Primary Angle Closure Glaucoma, PLoS Genetics, 10 (3), 2014/3.

Yang, Yingxin; Li, Zhen; * Wang, Ningli ; Wu, Lie; Zhen, Yi; Wang, Tao; Ren, Caixia; Peng, Xiaoxia; Hao, Jie; Xia, Yanting, Intraocular Pressure Fluctuation in Patients With Primary Open- angle Glaucoma Combined With High Myopia, Journal of Glaucoma, 23 (1), pp 19-22, 2014/1.

Wan, Xiu Hua; Li, Shi-Ming; Xiong, Ying; Liang, Yuan Bo; Li, Jing; Wang, Feng Hua; Li, Ji; Jhanji, Vishal; * Wang, Ning Li , Ocular Monochromatic Aberrations in a Rural Chinese Adult Population, Optometry and Vision Science, 91 (1), pp 68-75, 2014/1.

Li, Shi-Ming; Liu, Luo-Ru; Li, Si-Yuan; Ji, Ya-Zhou; Fu, Jing; Wang, Yang; Li, He; Zhu, Bi-Dan; Yang, Zhou; Li, Lei; Chen, Wei; Kang, Meng-Tian; Zhang, Feng-Ju; Zhan, Si-Yan ..., Design, Methodology and Baseline Data of a School-based Cohort Study in Central China: The Anyang Childhood Eye Study, Ophthalmic Epidemiology, 20 (6), pp 348-359, 2013/12.

Zhu, Bi-Dan; Li, Shi-Ming; Li, He; Liu, Luo-Ru; Wang, Yang; Yang, Zhou; Li, Si-Yuan; Kang, Meng-Tian; Fu, Jing; * Qi, Yan -Hua; Zhan, Si-Yan; Wang, Ningli , Retinal Nerve Fiber Layer Thickness in a Population of 12-Year-Old Children in Central China Measured by iVue-100 Spectral-Domain Optical Coherence Tomography: The Anyang Childhood Eye Study, Investigative Ophthalmology & Visual Science, 54 (13), pp 8104-8111, 2013/12.

Zhang, Shaodan; Xie, Yuan; Yang, Jie; Tang, Yangshuo; Li, Ruoxi; * Wang, Ningli ; Zhang, Chun, Reduced Cerebrovascular Reactivity in Posterior Cerebral Arteries in Patients with Primary Open-Angle Glaucoma, Ophthalmology, 120 (12 ), pp 2501-2507, 2013/12.

Wan Xiu-hua; Cai Xiao-gu; Qiao Li-ya; Zhang Ye; Tan Jia-xuan; Vishal, Jhanji; * Wang Ning-li , Effect of refractive correction on ocular optical quality measurement using double-pass system, Chinese Medical Journal, 126 (22), pp 4289-4294, 2013/11/20.

Lin, Zhong; Vasudevan, Balamurali; Jhanji, Vishal; Gao, Tie Ying; Wang, Ning Li ; Wang, Qi; Wang, Ji; Ciuffreda, Kenneth J .; * Liang, Yuan Bo, Eye exercises of acupoints: their impact on refractive error and visual symptoms in Chinese urban children, BMC Complementary and Alternative Medicine, Vol. 13, 2013/11/7.

Lin, Zhong; Liang, Yuanbo; * Wang, Ningli ; Li, Sizhen; Mou, Dapeng; Fan, Sujie; Sun, Sucijanti; Tang, Xin; Thomas, Ravi, Peripheral Anterior Synechia Reduce Extent of Angle Widening After Laser Peripheral Iridotomy in Eyes With Primary Angle Closure, JOURNAL OF GLAUCOMA, 22 (5), pp 374-379, 2013/7 JUN-JUL.

Liang, Yuan Bo; Xie, Cong; Meng, Hai Lin; Feng, Mei Yan; Fan, Su Jie; Liu, Luo Ru; Xie, Li Lian; Chao, Jia; Wang, Xing; * Wang, Ning Li ; Thomas, Ravi, Daytime Fluctuation of Intraocular Pressure in Patients With Primary Angle-Closure Glaucoma After Trabeculectomy, JOURNAL OF GLAUCOMA, 22 (5), pp 349-354, 2013/7 JUN-JUL.

* Zhang, Xinyuan; Wang, Ningli ; Barile, Gaetano R .; Bao, Shisan; Gillies, Mark, Diabetic retinopathy: Neuron protection as a therapeutic target, INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 45 (7), pp 1525-1529 , 2013/7.

Jiang, Liping; * Huang, Wen; Liang, Yuanbo; Wang, Fenghua; Duan, Xinrong; Yang, Xiaohui; Wen, Jiangping; Wang, Ningli , Metabolic syndrome, C-reactive protein and microalbuminuria in a rural Chinese population: a cross -sectional study, BMC NEPHROLOGY, Volume 14, 2013/6/2.

Hong, Jie; Zeng, Qiang; Wang, Huaizhou; Kuo, Debbie S .; Baldridge, William H .; * Wang, Ningli , Controlling the number of melanopsin-containing retinal ganglion cells by early light exposure, EXPERIMENTAL EYE RESEARCH, 111 , pp 17-26, 2013/6.

Li, Shi-Ming; Li, Si-Yuan; Liu, Luo-Ru; Guo, Ji-Yuan; Chen, Wei; * Wang, Ning-Li ; Millodot, Michel, Full correction and Undercorrection of Myopia Evaluation Trial: design and baseline data of a randomized, controlled, double-blind trial, CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 41 (4), pp 329-338, 2013/6 MAY-JUN.

For more than 229 scientific research results, please see Friends of Scientific Research. ^[6]

On July 31, 2015, he was selected as a preliminary candidate list for the Chinese Academy of Sciences. ^[7]