What Does a Sterilization Technician Do?
The sterilization methods commonly used in the production of pharmaceuticals include: autoclave sterilization, flow steam sterilization, boiling sterilization, filtration sterilization, and gas sterilization.
Sterilization technology
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- Chinese name
- Sterilization technology
- Solid
- technology
- Purpose
- Sterilize
- Examples of methods
- Autoclave sterilization
- The sterilization methods commonly used in the production of pharmaceuticals include: autoclave sterilization, flow steam sterilization, boiling sterilization, filtration sterilization, and gas sterilization.
- 60Co--ray sterilization is a rapid development method in recent years.
- It has strong penetrating power, easy operation, fast speed, can be sterilized at normal temperature, appropriate radiation dose, will not damage the active ingredients of the drug, will not cause harm to people, and control bacteria for a long time after sterilization Reproliferation and other advantages. Niuhuang Qingxin pills, Niuhuang Xiaoyan tablets and other eight varieties of finished products were sterilized by high, medium and low doses of 60Co- radiation. The research results showed that after the radiation dose of 25,000 Gy, the physical and chemical properties and content of the samples were affected. More obvious [113]. For example, the content of Niuhuang Qingxin pills decreased from 0.63% to 0.42%. However, irradiating the sample with medium (10,000 Gy) and low (4000 Gy, 2000 Gy) doses has little effect on the quality of the finished product. For example, the content of Niuhuang Qingxin pills is 0.62% (10,000 Gy), 0.63% (4000 Gy), 0.632% (2000 Gy). Judging from the changes in the amount of bacteria before and after irradiation: Honey pills use sterilization doses of 25,000 Gy, 10,000 Gy, and 400,000 Gy, and the sterilization efficiency is more than 96%, and with 2000Gy radiation, the sterilization efficiency is only about 90%. Changes in the physicochemical properties of the drugs suggest that 4000Gy conditions are more suitable for radiation sterilization. The sterilization effect of the three doses of the tablets reached more than 95%, so the 0.2Gy sterilization dose can be used. Comparing the sterilization effects of the microwave sterilization method and the radiation sterilization method, it is considered that the sterilization effect of both methods is very significant, and the microwave sterilization method is simpler and faster.