What are Catabolic Steroids?
Metabolic conditioning is the application of nutritional support and metabolic support to patients with hypermetabolism, supplying the body with energy and nitrogen sources, while using drugs or biological agents to regulate the metabolic response of substances in the body, change the body's response to disease, and inhibit the body's role in breaking down hormones , Reduce the rate of protein breakdown, so that the body's metabolism develops in a direction conducive to rehabilitation. In 1988, foreign scholars used radionuclide tracing to study the effects of drugs on sugar, protein, and fat metabolism in critically ill patients in surgery. The results showed that somatostatin, naloxone, ranitidine, phentolamine can Reduce the rate of proteolysis, put forward the concept of metabolic conditioning.
Basic Information
- Chinese name
- Metabolic conditioning
- Purpose
- Make the body's metabolism develop in a direction conducive to rehabilitation
Metabolic conditioning mechanism
- The human endocrine hormone can keep the human physiology in a balanced state, but when patients are under stress such as infection and trauma, the metabolic response is characterized by high catabolism, protein breakdown, and nitrogen loss. General nutritional support cannot correct protein in the body. Over-degradation, therefore, it is necessary to block the catabolism mechanism in vivo through metabolic conditioning, reduce high metabolic reactions, reduce catabolism of proteins, and increase protein synthesis.
Purpose of metabolic conditioning
- The existing nutritional and pharmacological treatment aims to suppress the body's role in breaking down hormones as much as possible, reduce catabolism, reduce the net protein breakdown rate, reduce the body's protein breakdown, save proteins, preserve organ structure and function, and make the body's metabolism towards Conducive to the development of rehabilitation.
Metabolic conditioning method
- The conditioning method has the following points.
1. Use synthetic hormones such as auxin, insulin and steroid hormones to promote cell growth and protein synthesis.
2. Antagonistic breakdown hormones such as somatostatin, receptor blockers such as phentolamine, ranitidine and naloxone.
3. Antagonistic cytokines such as anti-tumor necrosis factor antibodies.
4. Antagonize intracellular mechanisms, such as cyclooxygenase inhibitor indomethacin, cathepsin inhibitor leucine and so on.
5. Pharmacological nutrients such as glutamine and fish oil.