What Are the Different Diseases Associated with Mast Cells?
Mast cells are widely distributed around the microvessels under the skin and visceral mucosa. It secretes a variety of cytokines and participates in immune regulation (TB cells, APC cell activation). It expresses MHC molecule, B7 molecule and has APC function. Expresses a large number of IgE Fc receptors and releases allergic mediators. With weak phagocytosis. Like blood basophils, tissue cells with strong basophilic particles.
Mast cells
(Blood cells)
- Mast cells are widely distributed around the microvessels under the skin and visceral mucosa. It secretes a variety of cytokines and participates in immune regulation (TB cells, APC cell activation). It expresses MHC molecule, B7 molecule and has APC function. Expresses a large number of IgE Fc receptors and releases allergic mediators. With weak phagocytosis. And blood
- Mast cells are derived from
- Mast cell hyperplasia is a type of skin, bone,
- Skin involvement
- Also known as pigmented measles, this type is the most common, accounting for more than 90% of the disease. It is characterized by partial skin (easy to see on the face,
- Morphological diagnosis is mainly based on marrow cells found on the bone marrow slices stained by Ray-Jie's. Mast cells can be further confirmed by toluidine blue staining, which is characterized by cytoplasm filled with rose-red particles that are positive for toluidine blue staining. Especially helpful for the diagnosis of atypical mast cells.
- Biochemical diagnosis of significantly increased histamine levels in blood and urine is evidence of the diagnosis.
- X-ray plain radiography revealed osteogenic or osteolytic destruction of bones, and gastrointestinal radiography showed peptic ulcers and rough intestinal mucosa
- There is no effective treatment for mast cell hyperplasia, and only mast cell stabilizers such as ketotifen and tranilast can be taken orally. Immediately intramuscular injection of 1: 1000 epinephrine 0.4-0.6ml when mast cell syndrome occurred, and intravenous infusion of hydrocortisone plus vitamin C.