What Are the Symptoms of Acute Myeloid Leukemia?
Acute myeloid leukemia
Acute myeloid leukemia
- Acute myeloid leukemia
Overview of Acute Myeloid Leukemia
- Acute myelogenous leukemia (AML). WHO classifies myeloid tumors into four categories. AML is characterized by the accumulation of immature myeloid cells in the bone marrow and hematopoietic inhibition of the bone marrow. CMPD, a chronic myelodysplastic disease, often accompanied by an increase in the number of undifferentiated myeloid cells, a hyperplasia of the bone marrow, and an increase in peripheral blood cells. MDS, myelodysplastic syndrome, ineffective bone marrow hematopoiesis and peripheral blood cell reduction. MDS / MPD, myelodysplastic / myeloproliferative disease.
Clinical symptoms of acute myeloid leukemia
- Onset is fast, weeks or months, mainly manifested by anemia, bleeding, bone pain, fatigue, fever, liver and spleen. A group of heterogeneous tumors that differ in morphology, genetics, clinical manifestations, treatment, and prognosis. More common in adults, the peak incidence of 15-39 years.
- Bone marrow myeloid stem cells have a monoclonal hyperplasia, and have difficulty in differentiation and maturation. They stop at an early stage of myeloid differentiation (blast cells)> 25%.
Diagnosis of acute myeloid leukemia
- Blood and bone marrow images show a large number of immature granulocytes
Pathological changes of acute myeloid leukemia
- 1 Primitive granulocytes in bone
- 2 The total number of white blood cells in peripheral blood is increased, and a large number of primordial granulocytes can be seen.
- 3 The tumor cells mainly infiltrated in the paracortex of lymph nodes and sinuses, in the red pulp of the spleen, and in the liver sinus.
- Green tumor is myeloid leukemia, a type of localized infiltration of abnormal white blood cells under the periosteum or in soft tissue. Because of its pale green color (the presence of pale green pigment in the protoplasmic bone of tumor cells), the mass was round and raised like a tumor, hence its name. Patients with this disease are mostly healthy children, more common in men than women. The blood and bone marrow of leukemia often change, the course of disease is rapid and rapid, and it can die within months or even weeks.
Acute myeloid leukemia treatment
- There is currently no effective therapy and surgery is not appropriate.
- Combined sequential chemotherapy of acute myeloid leukemia
- The treatment of acute myeloid leukemia is usually combined with sequential chemotherapy, that is, after the initial remission (induction therapy) is obtained and post-remission therapy (consolidation therapy) is performed. The induction treatment plan depends on the patient's age and history of hematological disease, and the consolidation treatment plan after remission depends on cytogenetic risk factors. If the patient is not sensitive to the initial induction therapy, try radiation therapy. Because chemotherapy and radiotherapy can cause a certain degree of harm to the human body, in the treatment of acute myeloid leukemia, combined with traditional Chinese medicine treatment, its treatment advantages have the following aspects:
- 1. Application of traditional Chinese medicine during acute myeloid leukemia during chemoradiation can reduce the toxicity and increase the effect;
- 2. Acute myeloid leukemia After radiotherapy and chemotherapy, long-term adherence to Chinese medicine can stabilize the disease, improve long-term effects, and reduce the possibility of recurrence and metastasis.
- 3 Prevention and treatment of precancerous lesions.
- 4 Traditional Chinese medicine can improve symptoms, improve quality of life, and prolong life for patients with advanced myeloid leukemia who cannot accept chemoradiotherapy. In addition, if conditions permit, bone marrow transplantation is also one of the effective treatments for acute myeloid leukemia. Successful transplanters can generally obtain long-term survival or cure.
- Summarizing chemotherapy, induced differentiation (all-trans retinoic acid), bone marrow transplantation