What Is a Lip Biopsy?
Labial glands biopsy (labial glands biopsy) is a biopsy of the labial glands. It is a pathological examination of partial analysis of the labial gland leaflet biopsy under local anesthesia. Labial biopsy is one of the important objective indicators for the diagnosis of Sjogren's syndrome. The method is sensitive and specific.
Basic Information
- Chinese name
- Labial Gland Biopsy
- Foreign name
- labial glands biopsy
- Indication
- Mainly used for diagnosis of Sjogren's syndrome
- It is mainly used for the diagnosis of Sjogren syndrome (SS).
- Usually, the small salivary glands of the lips are selected for inspection. The lips can be removed with the midline slightly out of the skin. After the skin on the surface of the glands is disinfected, local anesthesia is performed. A small incision was made, and the tissue was removed from the tissue. The lip and mucosal tissue with normal surface and at least 4 glandular lobes was selected for pathological examination. Clusters of lymphocytes and plasma cells infiltrated in patients with lesions. The degree of lymphocyte aggregation in the acinar tissue was recorded. A cell number of 50 or more was a lesion. If more than 1 lymphocytic infiltrate was seen within 4 mm2, it was of diagnostic significance.
- The pathological grade of the labial biopsy is divided into grades according to Chisholm standards, with a focus (grade ) of infiltrating lymphocytes> 50 / 4mm2, moderate grade lymphocyte infiltration grade , and a small amount of grade , ranging from Grade is grade . Glandular tissue was found to be positive for more than 50 lymphocytes.
In addition to the symptoms of dry eyes and dry mouth, and positive biopsy of the labial glands, the diagnosis of SS requires: salivary gland function test, salivary flow rate <0.05ml / min is positive; parotid angiography: parotid duct and Gland destruction; radionuclide imaging: salivary gland uptake and excretory function decline in patients with xerostomia; autoantibodies: anti-SSA or anti-SSB antibodies (+) (double diffusion method); should be excluded: maxillofacial History of radiotherapy, hepatitis C virus infection, acquired immunodeficiency syndrome, lymphoma, sarcoidosis, GVH disease, application of anti-acetylcholine drugs (such as atropine, scopolamine, bromoproline, belladonna, etc.).