What Is Adenopathy?

Breast adenopathy is an early manifestation of dysplasia of the breast. The main changes are the obvious focal hyperplasia of the acinus and small ducts of the breast, and different degrees of connective tissue hyperplasia. The leaflet structure basically loses its normal shape, and even the acinar epithelial cells are scattered in the fibrous matrix. According to the development of the lesion, it can be divided into 3 stages: lobular hyperplasia, fibroblastic disease and sclerosing adenopathy.

Basic Information

English name

adenosis of breast

Visiting department

surgical

Multiple groups

Middle-aged

Common causes

Related to endocrine disorders and mental factors

Common symptoms

Periodic breast pain and lumps

Causes of breast disease

Generally believed to be related to endocrine disorders and mental factors. That is, it may be related to ovarian dysfunction, abnormal ratio of estrogen to progesterone, reduced lutein secretion, increased estrogen and prolactin secretion, leading to the onset of breast tissue hyperplasia.

Under normal circumstances, the human body maintains normal physiological functions under the joint regulation of the endocrine and nervous system. Various hormones are in a balanced state. If the balance is broken for various reasons, various clinical symptoms of endocrine disorders will occur. .

Clinical manifestations of breast adenopathy

The disease occurs in middle-aged people, and the time from onset to consultation is about 2 years. The age of onset is about 5 years earlier than breast cystic hyperplasia. Periodic breast pain and lumps are the main manifestations of the disease.

Periodic pain

Manifestations are that breast tenderness and menstrual pain increase before menstruation, and the pain is reduced or relieved after menstruation, and the lump becomes smaller. This periodic pain often varies depending on the type of lesion. Periodic pain is very obvious in the lobular hyperplasia type, pain is reduced in the fibroadenoid type, and there is almost no pain in the sclerotic type. The pain is usually bloating, acupuncture-like pain, or faint pain, which can radiate to the affected armpits and shoulders.

2. breast lump

Often multiple, can involve the breast on both sides but can also be single, the mass is generally small, more than 2cm in diameter. The masses vary in shape, appearing as patches, nodules, and strands, and the edges are not very clear. Mass hardness varies with the degree of fibrous tissue proliferation. The lobular hyperplasia type is tough and tough; the fibroadenoid type is moderate in hardness; the sclerosing adenopathy type is hard and sometimes misdiagnosed as cancer. The tenderness of the mass was obvious in the lobular hyperplasia type, followed by the fibroadenotype, and there was no tenderness in sclerosing adenopathy. Breast masses and pain often change due to mood changes such as chest tightness, uncomfortableness, and irritability. Especially in patients with lobular hyperplasia, when the mood fluctuates and becomes angry, the pain increases and the mass enlarges and hardens.

3. Menstrual disorders

Patients with lobular hyperplasia often have irregular months, short periods, and low menstrual flow.

Breast disease examination

Laboratory inspection

Fine needle aspiration cytology is the main basis for the diagnosis of the disease.

2. Other auxiliary inspections

(1) Molybdenum target radiographic lesions can be confined to a certain area of the breast, or can be widely diffused in the breast. The increased density of the hyperplasia of the breast is nodular or ground glass, the lesions are irregular in shape, and the edges are generally blurred. The density of the entire breast of diffuse lesions increases, the normal glandular structure disappears, and the shadows of the lesions tend to merge. A few patients may have relatively large calcifications, which are widely distributed in the lesion area.

(2) Ultrasound examination of the structure of the mammary gland, the echo of the gland tissue is thickened, the light spots are enhanced in granular form, and the proliferative nodules appear as uneven, low-echo areas with unclear borders, or banded strong echoes in the low-echo area. Mesh shadows, or "leopard-like" echo structures.

Breast disease diagnosis

Periodic breast pain and lumps in middle-aged women with regular changes in menstruation should be considered. X-ray photography and fine needle aspiration cytology can be used to confirm the diagnosis.

Breast disease treatment

Vitamin drug

Vitamin drugs have a protective effect on the liver, can improve liver function, thereby strengthening the inactivating effect of the liver on estrogen and regulating sex hormone metabolism. At the same time, it can improve autonomic nerve function and achieve the purpose of treating this disease.

(1) Vitamin A can promote the conversion of inactive peroxyandrosterone and progesterone into active androsterone and progesterone, the latter two of which have antagonistic effects on estrogen.

(2) Vitamin E is an antioxidant that can inhibit intercellular changes, regulate ovarian function, increase the serum progesterone / estradiol ratio, increase mature follicles, enlarge corpus luteum cells, and inhibit progesterone oxidation, increasing pregnancy The action of ketones thus corrects endocrine disorders.

(3) Vitamin B _{6 is} mainly involved in the metabolism of proteins and amino acids. Vitamin B6 deficiency can cause premenstrual tension. Excess estrogen This medicine has a certain effect on regulating the balance of sex hormones.

2. Hormone therapy

Routine use is generally not recommended, due to improper application will lead to hormonal disorders in the body, only when other treatments are ineffective, or patients with severe pain symptoms, can be used with caution.

(1) Androgen therapy methyltestosterone (methyltestosterone); testosterone propionate; Danazol and so on.

(2) Tamoxifen (Tamoxifen) is used continuously in patients with severe symptoms.

(3) The total effective rate of bromocriptine can reach 70% to 97%.

3. Surgical treatment

Surgical treatment can be used when the curative effect of drug treatment is not obvious, or it is difficult to distinguish clinically from breast cancer. The main operation is local resection of the mass. For patients with more masses, subcutaneous breast resection is feasible. Frozen sections should be done during the operation to confirm the diagnosis. Avoid misdiagnosis and perform radical breast cancer surgery that should not be done.