What is Estrogen Dominance?
Transdermal estrogen supplements are organisms that supplement vitamins in vitro.
Transdermal estrogen
Right!
- Chinese name
- Transdermal estrogen
- Types of
- biological
- Purpose
- Estrogen supplement
- Features
- in vitro
- Transdermal estrogen supplements are organisms that supplement vitamins in vitro.
- What are the advantages of estrogen?
- (1) Bioavailability: Oral estrogen is absorbed through the gastrointestinal tract, and is first metabolized and decomposed by the liver. Only 1% to 3% enters the systemic circulation to function, and the micronized estrogen bioavailability is not high. Transdermal estrogen can directly enter the systemic circulation, is basically not destroyed, and has high bioavailability, so it can reduce the total amount of medicine taken by patients.
- (2) Hepatobiliary effect: Oral estrogen causes an increase in hepatobiliary burden due to the first-pass effect of the liver; transdermal estrogen first enters the systemic circulation, the proportion of entering the liver is small, and it has little effect on hepatobiliary function.
- (3) Metabolic effects: In terms of lipid metabolism, transdermal estrogen can significantly reduce triglycerides without affecting the metabolism of plasma total cholesterol, low-density lipoprotein and high-density lipoprotein. In terms of glucose metabolism, both low and high doses of transdermal estrogen can increase insulin sensitivity without altering plasma growth hormone concentrations. In addition, transdermal estrogen does not alter the liver's effect on the renin-angiotensin-aldosterone system. Therefore transdermal estrogen is safer for patients with dyslipidemia, especially high triglycerides, diabetes and hypertension, and who need estrogen. Estrogen is the estrogen that the human body really needs, without the side effects of synthetic estrogen (estrogen analogues); topical plasters make dose control and use more convenient than oral and injection; absorbed through the skin to avoid the first-pass effect of the liver, Drugs are mostly distributed in target organs, which can reduce the risk of severe blood clotting or stroke, and can also reduce the risk of liver and gallbladder diseases; simulating the natural cycle plays a role in treating both the symptoms and the symptoms.
- (4) Coagulation function: There are many clinical trials that have confirmed that transdermal estrogen treatment can reduce the risk of venous thrombosis and cardiovascular events. Estrogen, which is administered orally, can have a minimal effect on the hepatic induction of coagulation factors and first-pass effect-related proteins, which is beneficial to the cardiovascular system. Especially compared with oral estrogen, the risk of deep vein thrombosis or pulmonary embolism is basically negligible.
- (5) Others: The ratio of serum estradiol to estrone is 2: 1 in fertile women and 1: 2 in postmenopausal women. The association between the abnormal ratio of both menopausal women and androgen secretion Sex may be a combined factor that increases the risk of coronary heart disease. After oral administration of estradiol, the ratio of serum estradiol to estrone is 1: 5, and the ratio of serum estradiol to estrone after transdermal estrogen enters the body is 1: 1, which is closer to the ratio of women in childbearing period.
- (6) Because of its stable activity, estradiol benzoate is used internationally as a standard substance for determining the international unit of estrogen activity. Benzoate-derived estradiol increases estradiol's fat solubility, enters cells more easily, and is more easily absorbed transdermally; bioactivity is improved, and it is more active than estradiol.
- Comparison of biological activities of several major estrogen
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- (7); Compared with other estrogen weekly patches that have been produced and marketed, it has a simulation similar to that of normal people's own secreted hormones, that is, the absorption peak generated after daily morning rubbing is close to the time when the human body secretes estrogen. Thereby avoiding the side effect of negative feedback inhibition of the human body's ability to secrete estrogen by constant release absorption of exogenous estrogen.
- Estradiol is the estrogen that the human body really needs, and estrone and estriol are its metabolites. They cannot be regarded as estrogen, especially estrogen. It is toxic, and is named "estrogen" by scientists. It should be minimized. Build up in the body. Estrogen replacement of transdermal estradiol is the only correct option
- All oral estrogen, whether natural or synthetic, undergoes a first-pass effect in the liver that greatly increases the estrone concentration, several times (5 times) the estradiol concentration. Research and products for oral estrogen supplementation should be abandoned.
- Even if oral estradiol, due to the first pass effect, the increase of estradiol in the blood is limited, it is still in a state of endocrine imbalance for a long time, and it is a cure for the symptoms. (Effect of long-term application of estradiol valerate on women's perimenopausal syndrome and Clinical Analysis of Safety in Chinese Maternal and Child Health Care 2010 Vol. 25 , P692-696 ).
- No matter what estrogen is taken orally, because of the first pass effect, the increase is "bad" estrogen-mainly estrone
- All oral estradiol- and estrone-based estrogens result in higher estrone levels than estradiol levels, because estradiol is metabolized by the intestinal mucosa during the first pass to estrone.
- The emergence of estrone drugs is a historical error that people have been eager to do next. It must not be used as a synonym for estrogen; what the body lacks and should be supplemented with estradiol, not estrone.
- 1. Dr. Diane F. Merritt, who has been working in the field of gynecology for many years, found that uterine fibroids, breast masses, ovarian cysts, and uterine fibroids were analyzed from resections of patients from 2001 to 2002, and the hormone metabolism garbage estrone and a large amount of deposition were found Aggregates of toxins, which stimulate glands, blood, bones, and organs, cause cell proliferation, swelling, and even cell mutation and canceration. This is the most commonly found toxin that is harmful to women's bodies and is named "estrogen". He said: female poison is a woman-specific toxin. Nearly a hundred common symptoms in women are related to the accumulation of female poison. For example: pigmentation with black and yellow plaques; irregular menstruation; heavy menstrual blood, dark red sticky, fishy smell with black blood clots; leucorrhea thin, strange taste, low immunity; breast tenderness before the menstruation, lower abdomen swell , Backache, abdominal pain during menstruation, cold hands and feet, insomnia, irritability, joint discomfort, osteoporosis, coldness and so on.
- 2. For humans, horse pregnancy estrone is a foreign substance, so the human body will continue to be inflamed due to intake of this substance, and C-reactive protein and IL = 6 increase. If you continue to be inflamed for five to fifteen years due to continuous intake of this substance, you will increase your risk of heart disease and Alzheimer's and affect the normal functioning of your organs.
- 3. Breast cancer has risen to the top of women's malignancies at present, with a higher incidence of 45-50 years of age, and an increased incidence after menopause, which may be related to an increase in the content of estrone in old age. (The clinical application value of ultrasound in diagnosing solid breast masses, Corps Medicine, 2009, 1 (19): 24-25; Surgery, Sixth Edition, People's Medical Publishing House 2006,327.
- 4. Clinically, menopausal women with the proportion of good estrogen and bad estrogen change, the incidence of breast cancer has increased significantly.
- 5. Dr. Ying Huang, a doctor of neurology and orthopedics, a bachelor of nutrition, a practicing physician in the United States, and a member of the American Association of Anti-Aging Medicine, gave a talk about hormones and diseases in China in 2009. Estrone was a "bad" estrogen.
- 6. Dr. Schwartzbain: I know that many women have been using these drugs for a long time. I would like to offer two points of advice to them now: First, do not use any drugs to replace hormones, because their role in the body is different. Second, don't think you can come up with a better way to use these drugs, this is the dead end. You should simulate existing physiological environments, such as using natural biological hormones. ("Sexy Years").
- 7. Reasons for increasing estrone ratio: decreased ovarian function, decreased estradiol and progesterone, increased FSH and LH (increased aromatase activity), obesity, oral estrogen (due to first-pass effects of the liver and gastrointestinal tract) Increased estrone), oral contraceptives, intake of exogenous estrogen, oxidative stress, etc.
- 8. Recent clinical studies have also demonstrated that oral estrone (in combination with estrogen) stimulates breast hyperplasia and proto-oncogene expression rather than transdermal estradiol.