What Is Leukocytoclastic Vasculitis?
Skin leukocyte fragmenting vasculitis (CLV) is a vascular inflammatory disease that affects the skin only for a variety of reasons.
Basic Information
- English name
- cutaneous leucocytoclastic vasculitis
- Visiting department
- dermatology
- Common causes
- Infections, drugs, immune disorders
- Common symptoms
- Skin damage, fever, myalgia, joint pain, etc.
Causes of cutaneous leukocyte fragmenting vasculitis
- The etiology of this disease is many, in addition to idiopathic, mainly related to the following factors.
- Infection
- Bacteria (Streptococcus, Mycobacterium, Leprosy, etc.), Viruses (Influenza Virus, Hepatitis B and C Virus, Epstein-Barr Virus), Fungi (Candida), Protozoa (Plasmodium, Trypanosoma), Worms (Schistosoma )Wait.
- 2. Drugs
- The application of penicillin, sulfa drugs, aspirin, etc. can induce the occurrence of this disease. Naproxen and methotrexate can also cause the disease. In addition, xenoprotein serum, pesticides can also be the cause of the disease.
- 3. Immune abnormalities
- Patients may have cryoglobulin, hypergammaglobulinemia, and so on.
Clinical manifestations of cutaneous leukocyte fragmenting vasculitis
- May have irregular fever, myalgia and joint pain. Skin lesions are mostly distributed in the lower extremities, and are more common in the lower legs and insteps. Sometimes thighs, buttocks, torso, and upper limbs can also appear. Skin lesions are diverse and can appear in batches during the acute phase. Purpuric ecchymosis is the most common and characteristic. It often rises above the skin surface and does not fade. There may be wind-like erythema, and severe blisters and blood blister. Pustules can also occur when neutrophils exudate into surrounding tissues. Sometimes there are subcutaneous nodules of varying sizes. Local ulcers and necrosis can occur if the endothelial is damaged and the lumen is narrowed. Occasional reticulum. The rash is sometimes accompanied by itching or pain, which usually lasts 2 to 4 weeks, and may have pigmentation or atrophic scars after absorption.
Skin Leukocyte Fracture Vasculitis Examination
- The white blood cell count is generally normal and can sometimes increase; platelets can be reduced during acute rashes, and erythrocyte sedimentation can be increased; serum complement can be reduced, and some patients can detect cold globulin and anticardiolipin antibodies (more common with IgA).
Diagnosis of skin leukocyte fragmenting vasculitis
- According to the characteristics of young adults, polymorphous skin lesions of the calf and the back of the foot are found, especially the palpable purpuric rash. The diagnosis of this disease should be considered.
Skin Leukocyte Fracture Vasculitis Treatment
- Glucocorticoid
- Glucocorticoids in the acute phase can well control symptoms and stabilize the condition. Like prednisone.
- 2. Other
- Colchicine is effective in some cases, and dapsone and tripterygium preparations can also be tried. Non-steroidal anti-inflammatory drugs are used to relieve joint and muscle symptoms. Enteric-coated aspirin and dipyridamole (persantin) can be used for anticoagulation therapy.