What Is Methylchloroisothiazolinone?

Methyl isothiazolinone (MIT) is a highly effective bactericide, a heat-resistant water-based preservative, and has a good effect on inhibiting the growth of microorganisms. It can inhibit the growth of bacteria, fungi, mold and mildew. Join personal care products, cosmetics, coatings, pulp and other fields.

Methyl isothiazolinone

Methyl isothiazolinone (MIT) is a highly effective bactericide, a heat-resistant water-based preservative, and has a good effect on inhibiting the growth of microorganisms. It can inhibit the growth of bacteria, fungi, mold and mildew. Join personal care products, cosmetics, coatings, pulp and other fields.

Chinese name

Methyl isothiazolinone

CAS number:

[2682-20-4]

Exterior:

Light yellow or colorless transparent liquid

Molecular weight:

115.15

Chemical name : 2-methyl-4-isothiazolin-3-one

Melting point: 254-256 ° C (lit.)

Density: 1.25 (14% aq.)

Vapor pressure: <0.1 mm Hg (25 ° C)

CAS database: 2682-20-4 (CAS DataBase Reference)

NIST chemical substance information: 3 (2H) -isothiazolone, 2-methyl- (2682-20-4)

EPA Chemical Substance Information: 3 (2H) -Isothiazolone, 2-methyl- (2682-20-4)

Security Information

Dangerous goods mark: N, C

Danger category code: 50 / 53-50-43-34-20 / 21/22

Safety instructions: 60-61-36 / 37 / 39-26-24-45

Dangerous Goods Transport Number: UN 3077 9 / PG 3

WGK Germany: 2

RTECS number: FE1250000

HazardClass: 8PackingGroup: III

toxicology:

LD50 (half lethal dose): 500mg / kg (data source: "Status and Development of Cosmetic Preservatives" 2007)

Toxicity classification: highly toxic

Chemical properties

Colorless with a certain odor.

use

Generally used as a preservative in baths, shampoos and washing liquids. It can be used in cooling water, circulating water, papermaking and paint coatings in industry.

use

It is a highly effective antimicrobial drug with a broad spectrum of bacteriostatic ability. It is used for sterilization and anticorrosion of papermaking coatings, oilfield water injection, and daily chemicals.

use

It is a widely used germicidal preservative, which can effectively kill algae, bacteria and fungi. The active single agent can be widely used in industrial cooling water, oil field tank water, paper industry, pipelines, coatings, paints, rubbers, cosmetics, photosensitive films and cleaning products. The effective amount is small, and it can be easily mixed in various formulas. The PH can be used in a wide range. After diluting the concentration, it can be easily biodegraded into non-toxic and pollution-free substances. Low toxicity, no residual emissions, good compatibility with various emulsifiers, surfactants and protein ingredients. MIT can effectively kill a variety of bacteria at low concentrations, and is especially suitable for the storage of cosmetics and personal care products. Applicable pH range pH2.0-12.0, miscible with water, can be added in any process, easy to operate

There are reports that this product is cytotoxic and neurotoxic . [1]

February 24, 2005

Notice of the Ministry of Health on the approval of 9.69% methyl isothiazolinone as a cosmetic raw material

(Wei Jianfa [2007] No. 172)

Provinces, autonomous regions, and municipalities directly under the Central Government Health Bureau (Bureau), Ministry of Health Health Supervision Center:

As reviewed by the Cosmetics Safety and Safety Review Committee of the Ministry of Health, "9.69% methylisothiazolinone" is now approved for use as a cosmetic preservative and listed in the "Cosmetic Hygiene Specification" (2007 edition). The specific requirements are as follows:

I. Name

(A) the name of the main ingredients

INCI name Standard Chinese translation: methyl isothiazolinone

INCI name: Methylisothiazolinone

Chemical name: 2-Methylisothiazol-3 (2H) -one

CAS number: 2682-20-4

(B) the main impurities

INCI name Standard Chinese translation: methylchloroisothiazolinone

INCI name: Methylchloroisothiazolinone

Chemical name: 5-Chloro-2-Methylisothiazol-3 (2H) -one

CAS number: 26172-55-4

Specification of raw materials

Methyl isothiazolinone content: 9.5% to 9.9%.

Methylchloroisothiazolinone content is 30ppm.

Water content: 90.1% to 90.5%.

PH value range: 3.0 6.0

Appearance: transparent liquid

Color APHA value <100

Density: 1.02

Restricted conditions of use

The maximum allowable concentration of methyl isothiazolinone in cosmetics is 0.01%; it is limited to use as a preservative.

May 28, 2007

Issuing department: Ministry of Health Issue date: May 28, 2007 Implementation date: May 28, 2007 (central regulations) ^[1]