What Is the Connection Between Hematology and Oncology?

Chen Baoan, a professor at Southeast University School of Medicine, is a nationally renowned expert in hematology and oncology.

Chen Baoan

(Nationally renowned expert in hematology and oncology)

Chen Baoan,

He is currently the leader of the Department of Hematology, Zhongda Hospital of Southeast University, the director of the Institute of Myelodysplastic Syndrome, and the director of the Department of Oncology. Concurrently

1. Research on tumor drug resistance: One of the main reasons for the failure of leukemia treatment is multidrug resistance. With funding from the National Natural Science Foundation of China, research found that tetrandrine is a non-selective calcium channel blocker. It can increase the inhibition rate of chemotherapeutic drugs on leukemia cells, and has no inhibitory effect on normal bone marrow cells. Myocardial toxic side effects are low, and the experimental dosage is clinically acceptable; tamoxifen can competitively inhibit the transport of chemotherapeutic drugs by membrane glycoproteins by improving the membrane structure. Both of them alone can reverse multidrug resistance. Experts have assessed that research in this area has reached the international advanced level.

2. Research on gene chip technology: Research on gene chips for detecting micrometastasis of tumors has been completed, and national intellectual property rights and invention patents have been obtained; and research on protein chips has been conducted. "Level" was published in Chinese Journal of Oncology in 2005. At present, the key project Development of micro-transfer gene chip and its application in gastrointestinal malignancies funded by the Jiangsu Provincial Department of Health is underway.
3. Physical principles and biological effects of blocking neovascularization of tumors: Treatment measures against tumor angiogenesis can become a novel anti-cancer approach. Current research in this area has focused on tumor angiogenic factors and anti-endothelial cell proliferation and migration. Through previous research, it has been found that the neovascularization of tumors is directly damaged by the effects of ultrasonic cavitation and the cavitation nucleus, and experimental studies on tumor blood vessel occlusion caused by low-power ultrasound radiation of carbon dioxide microbubbles have been completed. Further research will be done on animal transplanted tumors, and clinical studies are planned to establish a new method for non-invasively inducing tumor neovascular endothelial cell damage and blocking tumor blood supply.
4. Hematopoietic stem cell transplantation: 36 cases of non-myeloablative hematopoietic stem cell transplantation have been carried out in recent years, with satisfactory results, small side effects associated with treatment, and low economic costs, which have freed patients with leukemia from illness, and is currently at the leading domestic level in the country. The impact has been profound. ^[2]

1. 2007 "Research on Resistance Reversion of Leukemia" Second Prize of Jiangsu Province Science and Technology Progress

2. 2006 "Detection of Micrometastasis in Peripheral Blood of Patients with Gastrointestinal Malignant Tumors and Development and Application of Micrometastases Gene Chips" Third Prize of Jiangsu Province Science and Technology Progress Award

3. 2006 "Basic and Clinical Research on the Combination of Chinese and Western Medicine to Increase the Chemosensitivity of Hematological Tumor Chemotherapy" Third Prize of Science and Technology Award of China Society of Integrated Chinese and Western Medicine

4. In 2009, "Research and application of multiple methods to reverse multidrug resistance in leukemia" won the second prize of the Ministry of Education's scientific and technological progress.

5. In 2011, "Research on Identification and Reversal of Tumor Resistance Based on Nano-biotechnology" won the Second Prize of Science and Technology Progress of the Ministry of Education.

He has won the Second Prize of Science and Technology Progress Award of the Ministry of Education, and the Second Prize of Science and Technology Progress Award of Jiangsu Province. 5 national projects and 3 provincial and ministerial second prizes.

1. Wang Xuemei, Zhang Renyun, Lu Gang, Wu Chunhui, Li Jingyuan, Gao Feng, Cheng Jian, Chen Baoan, Fu Degang, Li Xiaomao,

Guan Zhiqun. Targeted magnetic nanomedicine for treating leukemia and preparation method thereof. Patent No .: ZL 2005 1 0040657.1.

2. Wang Xuemei, Wu Chunhui, Song Min, Li Jingyuan, Zhang Renyun, Wu Dehong, Yan Hong, Gu Zhongze, Chen Baoan. Organic Gold

A method for preparing a carborane targeted nano preparation and a targeting preparation made therefrom. Patent number: ZL 2006 1 0096423.3.

1. General project of National Natural Science Foundation of China: Study on the mechanism of reversal of multidrug resistance of leukemia cells by tetrandrine and carnoprofen (No. 39970832, research period: 2000.11-2002.12)

2. A major project in Nanjing: non-myeloablative hematopoietic stem cell transplantation for leukemia (No. YQ0008, research period: 2001-2004)

3. Science and Technology Development Fund of Jiangsu Provincial Department of Health: Biological therapy in vitro purification of slow-granular ASCT (No. H200344, research period: 2003-2005)

4. Major project of Zhongda Hospital of Southeast University: Non-myeloablative hematopoietic stem cell transplantation for the treatment of hematological diseases (No. 2003YJ02, research period: 2003-2005)

5. Special scientific research fund for doctoral disciplines in colleges and universities: the mechanism of magnetic nanometer iron trioxide particles copolymerized with tetrandrine and chemotherapeutics in reversing multidrug resistance of hematological malignancies (No. 20070286042, research period: 2008 2010) closed

6. National Natural Science Foundation of China: Mechanism study of magnetic nano-iron ferric oxide particles copolymerized with tetrandrine and chemotherapeutics in reversing multidrug resistance of hematological malignancies (No. 30740062, research period: 2008-2009 ) Concluded 7. National Natural Science Foundation of China: Magnetic Nano-Ferric Oxide Particles Copolymerize Daunorubicin and 5-Bromohendrine to Reverse the Multidrug Resistance of Malignant Hematological Diseases (No. 30872970, Research period: 2009-2011) Completed questions 8. National high-tech research and development plan (863 plan) Sub-project: Treatment of acute leukemia (Research period: 2009-2011) Completed questions

9. Sub-project of National High-Tech Research and Development Program (863 Program): Research and Development of Ultra-Sensitive Nano-Porous Biosensors (No. 32007AA022007, Research Period: 2009-2011)

10. National key basic research development plan (973 plan) sub-project: Research on sensing and imaging methods based on biomimetic molecular recognition and system design (No. 2010CB732404, research period: 2009-2015)

11. National Science and Technology Support Project (Eleventh Five-Year Plan) Sub-project: Research on standardized diagnosis and treatment strategy of myelodysplastic syndrome (No. 2008BAI61B02, research period: 2008-2010)

12. General Program of National Natural Science Foundation of China: Design of chemotherapeutic drugs, traditional Chinese medicine and transferrin nanocarriers, and research on the mechanism of reversing leukemia resistance (No. 81170492, research period: 2012-2015)

13. National high-tech research and development plan (863 plan) sub-project: the development of low-cost detection systems for biomarker detection (No. 2012AA022703, research period: 2012-2016)

14. National Natural Science Foundation of China: Research on the development of platelet-targeted drug delivery system and its anti-leukemia effect (No. 81370673, research period: 2014-2017)

15. Key Medical Project of Jiangsu Provincial Department of Science and Technology: Standardized treatment of relapsed and refractory leukemia in Jiangsu Province (No. BL2014078, research period: 2014-2017) is under development ^[1]

1.CaiX, Cai X, Wang C, Chen B A * , Hua W, Shen F et al. Antitumor efficacy of DMSA modified Fe3O4 magneticnanoparticles combined with arsenic trioxide and adriamycin in Raji cells. J Biomed Nanotech 2014; 10 (2) : 251-261.

2.ChangH, Wang X, Shiu KK, Zhu Y, Wang J, Li Q, Chen BA * et al. Layer-by-layer assembly of graphene, Au and poly (toluidine blue O) films sensor for evaluation of oxidative stress of tumorcells elicited by hydrogen peroxide. Biosensors & Bioelectronics 2013; 41: 789-794.

3.ChengJ, Cheng L, Chen B A * , Xia G, Gao C, Song H et al. Effect of magnetic nanoparticles of Fe3O4 and wogonin on the reversal of multidrug resistance in K562 / A02 cell line. Int J Nanomedicine 2012; 7: 2843-2852.

4.FangL, Chen B A , Liu S, Wang R, Hu S, Xia G, Chen BA * et al. Synergistic effect of a combination of nanoparticulate Fe3O4 and gambogic acidon phosphatidylinositol 3-kinase / Akt / Bad pathway of LOVO cells. Int JNanomedicine 2012; 7: 4109-4118.

5.JiangN, Zhu X, Zhang H, Wang X, Zhou X, Gu J, Chen BA * et al. The relationship between methylenetetrahydrofolatereductase polymorphism and hematological malignancy. Clin Lab 2014; 60 (5) : 767-774.

6.JinN, Malcherek G, Mani J, Zurleit R, Schmitt A, Chen B A et al. Suppression of cytomegalovirus-specific CD8 (+) T cells by everolimus. Leuk Lymphoma 2014; 55 (5) : 1144-1150.

7. LiK, Chen B A * , Xu L, Feng J, Xia G, Cheng J et al. Reversal of multidrug resistance by cisplatin-loaded magnetic Fe3O4nanoparticles in A549 / DDP lung cancer cells in vitro and in vivo. Int J Nanomedicine 2013 ; 8: 1867-1877.

8. LiangG, Li J, Sun B, Li S, Lu L, Wang Y, Chen BA * et al. Deep sequencing reveals complex mechanisms of microRNA deregulation in colorectal cancer. Int J Oncology 2014; 45 (2) : 603-610.

9.LuX, Zhu A, Cai X, Jia Z, Han W, Ma L, Chen BA * et al. Role of NKG2D in cytokine-induced killer cellsagainst multiple myeloma cells. CancerBio Therapy 2012; 13 (8) : 623-629 .

10.MouY, Hou Y, Chen B A * , Hua Z, Zhang Y, Xie H et al. In vivo migration of dendritic cells labeled with synthetic superparamagnetic iron oxide. Int J Nanomedicine 2011; 6: 2633-2640.

11.RenY, Zhang H, Chen B A * , Cheng J, Cai X, Liu R et al. Multifunctional magnetic Fe3O4 nanoparticles combined withchemotherapy and hyperthermia to overcome multidrug resistance. Int J Nanomedicine 2012; 7: 2261-2269.

12.SongG, Gu L, Li J, Tang Z, Liu H, Chen B A * et al. Serum microRNAexpression profiling predict response to R-CHOP treatment in diffuse large Bcell lymphoma patients. Ann Hematol 2014. e-pub ahead of print 2014/05/27

13. WangC, Cai X, Chen B A * , He Z, Chen Z, Cen J et al. Up-regulation of tissue inhibitor of metalloproteinase-2promotes SHI-1 cell invasion in nude mice. Leuk Lymphoma 2013; 54 (12) : 2707-2711.

14.WangC, Zhang H, Chen Y, Shi F, Chen B A * . Gambogic acid-loaded magnetic Fe (3) O (4) nanoparticles inhibit Panc-1 pancreatic cancer cell proliferation and migration by inactivating transcription factor ETS1. Int J Nanomedicine 2012; 7: 781-787.

15.Wang F, Zhang W, Guo L, Bao W, Jin N, Liu R, Chen BA * et al. Gambogic acid suppresses hypoxia-induced hypoxia-inducible factor-1alpha / vascular endothelial growth factor expressionvia inhibiting phosphatidylinositol 3-kinase / Akt / mammalian target protein ofrapamycin pathway in multiple myeloma cells. Cancer Sci 2014. e-pub ahead of print 2014/06/04.

16. WangL, Zhang H, Chen B A * , Xia G, Wang S, Cheng J et al. Effect of magnetic nanoparticles on apoptosis and cell cycle induced by wogonin in Raji cells. Int J Nanomedicine 2012; 7: 789-798.

17. WangX, Wang X, Gao S, Zheng Y, Tang M, ChenB A * . A solid-state electrochemiluminescencesensing platform for detection of catechol based on novel luminescent compositenanofibers. Talanta 2013; 107: 127-132.

18.WenJ, Jiang S, Chen Z, Zhao W, Yi Y, Yang R, Chen BA * et al. Apoptosis selectively induced in BEL-7402 cells by folic acid-modified magnetic nanoparticles combined with 100 Hz magnetic field. Int J Nanomedicine 2014; 9: 2043-2050.

19. XuP, Chen B A * , Feng J, Cheng L, Xia G, Li Y et al. Polymorphisms in XPC provide prognostic information in acute myeloid leukemia. Int J Hematology 2012; 96 (4) : 450-460.

20.XuP, Li J, Chen B A * , Wang X, Cai X, Jiang H et al. The real-time neurotoxicity analysis of Fe3O4 nanoparticles combined with daunorubicin for rat brain invivo. J Biomed Nanotechnology 2012; 8 (3) : 417 -423.

21.XuP, Li J, Shi L, Selke M, Chen B A * , Wang X. Synergetic effect of functionalcadmium-tellurium quantum dots conjugated with gambogic acid for HepG2cell-labeling and proliferation inhibition. Int J Nanomedicine 2013; 8: 3729- 3736.

22.XuY, Wang Y, Li XM, Huang Q, Chen W, Liu R, Chen BA * et al. Study on the release of fenofibrate nanosuspension invitro and its correlation with in situ intestinal and in vivo absorptionkinetics in rats. Drug Dev Indus Pharmacy 2014; 40 (7) : 972-979.

23. YangZ, Chen B A * , Pei X, Shangguan F. Multiplex analysis of tumor multidrug-resistance genes expression with photonic suspension array. The Analyst 2012; 137 (14) : 3343-3348.

24. ZhangH, Wang C, Chen B A * , Wang X. Daunorubicin-TiO2 nanocompositesas a "smart" pH-responsive drug delivery system. Int J Nanomedicine 2012; 7: 235-242.

25. ZhongY, Wu J, Chen B A * , Ma R, Cao H, Wang Z et al. Investigation and analysis of single nucleotide polymorphisms in Janus kinase / signal transducer and activator of transcriptiongenes with leukemia. Leuk Lymphoma 2012; 53 (6) : 1216-1221.

26. Zhang HJ, Chen BA * , Jiang H, Wang CL, Wang HP, Wang XM. A strategy for ZnO nanorod mediated multi-mode cancer treatment. Biomaterials. 2011; 32 (7): 1906-14.

27. Chen BA * , Wu WW, WangXM. Magnetic Iron Oxide Nanoparticles for Tumor-targeted Therapy. Curr CancerDrug Targets 2011; 11 (2): 184-9.

28. Zhang HJ, Jiang H, Sun FF, Wang HP, Zhao J, Chen BA * , Wang XM. Rapid diagnosis of multidrug resistance in cancerby electrochemical sensor based on carbon nanotubes-drug supramolecularnanocomposites. Biosens Bioelectron. 2011; 26 (7) : 3361-6.

29. Song M, Zhang RR, Dai YY, Gao F, Chi H, Lv G, Chen BA , * Wang XM. The in vitro inhibition of multidrug resistance by combined nanoparticulate titanium dioxide and UV irradition. Biomaterials. 2006; 27 (23) : 4230-8.

30. Chen BA * , Yin L, ChengJ, Ding JH, Gao C, Sun YY, Zhao G, Wang J, Bao W, Xia GH, Gao F, Wang XM. Effect of D, L-threo-1-phenyl- 2-decanoylamino-3-morpholino-1 -propanol andtetrandrine on the reversion of multidrug resistance in K562 / A02 cells. Hematology. 2011; 16 (1): 24-30.

31. Wu WW, Chen BA * , ChengJ, Wang J, Xu WL, Liu LJ, Xia GH, Wei H, Wang XM, Yang M, Yang L, Zhang Y, XuC, Li J. Biocompatibility of Fe3O4 / DNR magnetic nanoparticles inthe treatment of hematologic malignancies. Int J Nanomedicine. 2010; 5: 1079-84.

32. Wang J, Chen Y, Chen BA * , Ding JH, Xia GH, Gao C, Cheng J, Jin N, Zhou Y, Li XM, Tang M, Wang XM. Pharmacokinetic parameters and tissue distribution of magnetic Fe (3) O (4) nanoparticlesin mice. Int J Nanomedicine. 2010; 5: 861-6.

33. Chen BA * , Mao P, ChengJ, Gao F, Xia GH, Xu WL, Shen HL, Ding JH, Gao C, Sun Q, Chen W, Chen N, LiuLJ, Li XM, Wang XM. Reversal of multidrug resistance by magnetic Fe3O4nanoparticle copolymerizating daunorubicin and MDR1 shRNA expression vector inleukemia cells. Int J Nanomedicine. 2010; 5: 437-4.

34. Chen BA * , Jin N, WangJ, Ding JH, Gao C, Cheng J, Xia GH, Gao F, Zhou Y, Chen Y, Zhou G, Li XM, ZhangY, Tang M, Wang XM. The effect of magnetic nanoparticles of Fe (3) O (4) on immune function in normal ICR mice. Int J Nanomedicine. 2010; 5: 593-9.

35. Zhang HJ, Jiang H, Wang XM, Chen BA * . Reversion of multidrugresistance in tumor by biocompatible nanomaterials. Mini Rev Med Chem. 2010; 10 (8): 737-45.

36. Zhong YJ, Chen BA * , Feng JF, Cheng L, Li Y, Qian J, Ding JH, Gao F, Xia GH, Chen N, Lu Z. The associations of Janus kinase-2 (JAK2) A830G polymorphism and the treatment outcomesin patients with acute myeloid leukemia. Leuk Lymphoma. 2010; 51 (6): 1115-20.

37. Zhu XL, Zhang HJ, Lin Y, Chen P, Min J, Wang Z, Xiao W, Chen BA * . Mechanisms of gambogicacid-induced apoptosis in non-small cell lung cancer cells in relation to transferrinreceptors. J Chemother. 2009 ; 21 (6): 666-72.

38. Pei XP, Chen BA * , LiL, Gao F, Jiang Z. Multiplex tumor marker detection with new chemiluminescentimmunoassay based on silica colloidal crystal beads. Analyst. 2010; 135 (1): 177-81.

39. Chen BA * , Liang YQ, WuWW, Cheng J, Xia GH, Gao F, Ding JH, Gao C, Shao Z, Li G, Chen W, Xu WL, SunXC, Liu LJ, Li XM, Wang XM. Synergistic effect of magnetic nanoparticles ofFe (3) O (4) with gambogic acid on apoptosis of K562 leukemia cells. Int J Nanomedicine. 2009; 4: 251-9.

40. Cheng J, Wu WW, Chen BA * , Gao F, Xu WL, Gao C, Ding JH, Sun YY, Song HH, Bao W, Sun XC, Xu C, Chen W, Chen N, Liu LJ, Xia GH , Li XM, Wang XM. Effect of magnetic nanoparticles ofFe3O4 and 5-bromotetrandrine on reversal of multidrug resistance in K562 / A02leukemic cells. Int J Nanomedicine. 2009; 4: 209-16.

41. Pei XP, Zhao Y, Zhao X, Xu H, Chen BA * , Gu ZZ. Multiplex chemiluminescent immunoassay based onsilica colloidal crystal beads. JN N. 2009; 9 (11): 6320-5.

42. Sun N, Sun XC, Chen BA * , Cheng H, Feng JF, Cheng L, Lu ZH. MRP2 and GSTP1 polymorphisms and chemotherapy response in advanced non-small cell lung cancer. Cancer Chemoth Pharm. 2010; 65 (3): 437-46.

43. Li Y, Deng Z, Xuan H, Zhu J, Ding B, Liu X, Chen BA * . Prolonged chronic phase in chronic myelogenous leukemiaafter homoharringtonine therapy. Chin Med J (Engl). 2009; 122 (12): 1413- 7.

44. Jiang Z, Chen BA * , XiaGH, Wu Q, Zhang Y, Hong T, Zhang W, Cheng J, Gao F, Liu LJ, Li XM, Wang XM. Thereversal effect of magnetic Fe3O4 nanoparticles loaded with cisplatin onSKOV3 / DDP ovarian carcinoma cells. Int J Nanomedicine. 2009; 4: 107-14.

45. Chen BA * , Cheng J, WuYN, Gao F, Xu WL, Shen HL, Ding JH, Gao C, Sun Q, Sun XC, Cheng H, Li G, ChenW, Chen N, Liu LJ, Li XM, Wang XM. Reversal of multidrug resistance by magneticFe3O4 nanoparticle copolymerizating daunorubicin and 5-bromotetrandrine inxenograft nude-mice. Int J Nanomedicine. 2009; 4: 73-8.

46. Chen BA * , Cheng J, Shen MF, Gao F, Xu WL, Shen HL, Ding JH, Gao C, Sun Q, Sun XC, Cheng H, Li G, Chen W, Chen N, Liu LJ, Li XM , Wang XM. Magnetic nanoparticle of Fe3O4 and5-bromotetrandrin interact synergistically to induce apoptosis by daunorubicin inleukemia cells. Int J Nanomedicine. 2009; 4: 65-71.

47. Chen BA * , Dai YY, WangXM, Zhang R, Xu WL, Shen HL, Gao F, Sun Q, Deng X, Ding JH, Gao C, Sun Y, ChengJ, Wang J, Zhao G, Chen N. Synergistic effect of the combination of nanoparticulateFe3O4 and Au with daunomycin on K562 / A02 cells. Int J Nanomedicine. 2008; 3 (3): 343-50.

48. Chen BA * , Sun Q, WangXM, Gao F, Dai YY, Yin Y, Ding JH, Gao C, Cheng J, Li JY, Sun XC, Chen N, XuWL, Shen HL, Liu D. Reversal in multidrug resistance by magnetic nanoparticleof Fe3O4 loaded with adriamycin and tetrandrine in K562 / A02 leukemic cells. IntJ Nanomedicine. 2008; 3 (2): 277-86. ^[1]

He is the editor of "Reversal of Multidrug Resistance in Malignant Tumors" ^[3] , and has edited many books. He has presided over 5 research projects of the National Natural Science Foundation of China, participated in "973", "863", and scientific and technological support. He has published more than 400 academic papers, of which nearly 100 have been included in SCI, and 3 books have been edited by the chief editor.

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