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Enteroviruses include poliovirus, Coxsackie virus, enterocytopathic human orphan virus (ECHO for short) and new enteroviruses. There are 71 serotypes. Infection is widespread and clinical manifestations are complex and diverse. Poliomyelitis has a special chapter. This section introduces enterovirus infections other than enteroviruses other than poliovirus.

Enterovirus infection

Enterovirus
Enterovirus includes
Acute hemorrhagic caused by enterovirus type 70 from 1969 to 1973
Humans are the only natural host of human enteroviruses. The virus spreads through close contact between humans (through fingers, tableware, and food). Viruses are present in the throat and intestines of infected people, and it takes longer to remove the virus from feces, which can last for several weeks. Fecal-mouth is the main route of transmission. It can also be spread by droplets by accident. The virus lives in sewage for a long time.
Onset and clinical manifestations After the human has ingested the virus, after 7 to 14 days, the virus that is present in the lymphoid tissues of the pharynx and intestine passes through the bloodstream to proliferate into the mononuclear phagocytes, and finally reaches the target organ (such as spinal cord, brain, Meninges, heart, liver, skin, etc.), cause corresponding clinical symptoms in different organs.
The acute hemorrhagic conjunctivitis caused by enterovirus type 70 is usually sudden, with severe eye pain, photophobia,
Depends on detection of pathogens and antibodies. These viruses can be found in feces, blood, cerebrospinal fluid, spinal cord, conjunctival secretions, and lesions in the throat, brain, heart, liver, and skin or mucous membranes. The virus can be isolated by tissue culture or animal inoculation, and then identified by corresponding antisera. Fast and sensitive methods for detecting antigens include immunofluorescence, enzyme-linked immunosorbent detection, and nucleic acid hybridization. Test the antibody titer of the serum in the acute phase and the recovery phase. If the antibody titer is increased by more than 4 times, the diagnosis can be confirmed. There is a neutralization test.
There are no specific treatments available. Symptomatic treatment is used and most patients can recover.
Poliomyelitis vaccine is very effective. However, there is no specific control method for other enterovirus infections. Infants and young children should avoid
The clinical manifestations of enterovirus infections are complex and changeable, with very different conditions. Isotype viruses can cause different clinical syndromes, and different types of viruses can cause similar clinical manifestations.
(One)
1. Epidemiological contact history and onset season have certain reference value for diagnosis;
Second, the clinical manifestations of the above clinical symptoms without other reasons can explain the possibility of enterovirus infection should be considered;
Third, laboratory inspection
1. Virus isolation. Virus isolation from patient body fluids (pleural fluid, pericardial fluid, cerebrospinal fluid, blood, herpes fluid, etc.) or biopsy and autopsy tissue is of diagnostic value, but the virus alone from throat swabs or stool cannot be diagnosed. If the same type of virus is repeatedly isolated from the throat swabs or feces of patients with the above clinical symptoms group, and the same virus is also detected from those with the same disease around, and the virus isolation rate is much higher than that of the normal population, then a diagnosis is made Reference value.
2. Serology. The serum neutralizing antibody titer increased by more than 4 times in early and recovery stage, which is of diagnostic value.

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