What Is Stitch and Glue?

A research team at Stanford University School of Medicine has used two ready-made substances: the organic polymer "poloxamer 407", and the bioadhesive "multi-stick". The former is used to open both ends of the blood vessel. The latter is used for bonding.

Bio glue

Right!

In surgery, connecting broken and ruptured blood vessels has always been "needlework", but suture is not suitable for particularly small blood vessels. "Bio glue" is a new method invented by American researchers. Using "bio glue" can bind small blood vessels and avoid some of the side effects of suture.

United States

Poloxamer 407 is non-toxic to the human body and has been approved as an excipient for some pharmaceuticals and personal care products. It has a unique property that it is liquid at low temperatures, becomes solid when heated, and the process is reversible. The new method takes advantage of this feature. Researchers heated the substance above body temperature, turning it into a solid that was used to propagate blood vessels. When the temperature drops, it returns to its liquid state so that it does not block blood vessels.

Researchers in animals have shown that the new method is more efficient than traditional vascular sutures and can join blood vessels that are only 0.2 millimeters thick, which is difficult to process with blood vessels less than 1 millimeter in diameter. In addition, the damage caused by needle lines can cause intimal hyperplasia or inflammation of blood vessels, thereby increasing the risk of vascular embolism. The new method does not have this risk.

Related papers were published on the online edition of the journal Nature and Medicine on August 28, 2011. This method requires more animal tests and subsequent human tests to confirm its safety and effectiveness before it can be put into practical use. The researchers believe that because the two substances used have previously been certified by the US Food and Drug Administration, the method The speed to clinical applications may be fast.