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Hydrocortisone sodium succinate, also known as hydrocortisone sodium succinate; hydrocortisone, chemical name is 11, 17-dihydroxy-21- (3-carboxy-1-hydroxypropoxy) progesterone-4 -Ene-3,20-dione, a white or almost white loose bulk. Hydrocortisone sodium succinate is a hydrocortisone salt compound. It has a variety of pharmacological effects such as anti-inflammatory, anti-allergy and immune suppression. (1) Anti-inflammatory effect: glucocorticoids reduce and prevent tissues from responding to inflammation, thereby reducing the manifestation of inflammation. (2) Immunosuppressive effect: prevent or suppress the immune response mediated by cells, delayed allergic response, and reduce the expansion of the primary immune response. (3) Anti-toxic and anti-shock effects: Glucocorticoids can fight the stimulating response of bacterial endotoxin to the body, reduce cell damage, and play a role in protecting the body

Hydrocortisone sodium succinate

Hydrocortisone sodium succinate

English name: Hydrocortisone Sodium Succinate

English alias: Hydrocortisone-21-sodium Succinate; Hydorcortisone Sodium Succinate; sodium 4-[(11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl) oxy] -4-oxobutanoate; sodium 4- { [(11beta) -11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl] oxy} -4-oxobutanoate

CAS: 125-04-2

EINECS: 204-725-5

[Properties] The product is white or off-white powder; odorless; yes

Oral absorption is rapid, Tmax is 1h, T1 / 2 is 1.6h,

Long-term massive application

1. Induced infection: Under the action of hormones, the infection that has been controlled can move. The most common is recurrence of tuberculosis infection. Application of hormones in certain infections can reduce tissue damage, reduce exudation, and reduce symptoms of infection poisoning, but must be treated with effective antibiotics at the same time, closely observe changes in the condition, after short-term medication, it should be quickly reduced and discontinued.

2. Interference to diagnosis:

(1)

Oral:

1. Take 1% of the product in water and add an equal volume of

Take this product for drying weight loss and dry it at 105 ° C for 3 hours. The weight loss should not exceed 2.0% (Appendix L).

Take the sodium content 1.0g, accurately weigh, add ice

Add 2010 version

medicine interactions

Non-steroidal anti-inflammatory analgesics can enhance its ulcer-causing effect.

can enhance the liver toxicity of acetaminophen.

(3) Combined with amphotericin B or carbonic anhydrase inhibitor, it can aggravate hypokalemia, and long-term combined with carbonic anhydrase inhibitor, prone to hypocalcemia and osteoporosis.

Combination with protein assimilation hormone can increase the incidence of edema and make acne worse.

Long-term combination with anticholinergic drugs (such as atropine) can cause increased intraocular pressure.

Tricyclic antidepressants can aggravate the mental symptoms it causes.

When combined with hypoglycemic agents such as insulin, the dose of hypoglycemic agents should be adjusted appropriately because it can increase blood sugar in patients with diabetes.

Thyroid hormone can increase its metabolic clearance rate, so the dose of the latter should be adjusted appropriately in combination with thyroid hormone or antithyroid drugs.

Combination with contraceptives or estrogen preparations can enhance its therapeutic effect and adverse reactions.

The combination of tincture with cardiac glycoside can increase the toxicity of digitalis and heart rhythm disturbance.

Combined with potassium-releasing diuretics, it can cause severe hypokalemia, and attenuate the sodium-releasing and diuretic effects of diuretics due to water and sodium retention.

The combination of tincture with ephedrine can enhance its metabolic clearance.

Combined with immunosuppressants can increase the risk of infection and may induce lymphoma or other lymphoplastic diseases.

Radon can increase the metabolism and excretion of isoniazid in the liver, reduce the plasma concentration and efficacy of isoniazid.

Can promote the metabolism of mexiletine in the body and reduce blood concentration.

Cooperating with salicylate can reduce the concentration of salicylate in plasma.

combined with growth hormone can inhibit the growth-promoting effect of the latter.