What Are Dexamethasone Eye Drops?

Tobramycin and dexamethasone eye drops, the indications are: 1. ophthalmic inflammatory lesions that are responsive to adrenal corticosteroids and bacterial infections on the surface of the eye or are at risk of infection; 2. ophthalmic hormones for eyelids, Inflammatory diseases such as bulbar conjunctiva, cornea, anterior segment of the eyeball, and some infectious conjunctivitis that can accept the potential danger of hormones can reduce edema and inflammatory response. They are also suitable for chronic anterior uveitis, chemical, radioactive, burn and foreign body penetrating corneal damage; 3. Compound preparations with anti-infective ingredients can be applied to areas where there is a high risk of ocular surface infection and a large number of bacteria are expected When it is potentially dangerous to the eyes; the unique anti-infective drugs in this product are effective against some common eye bacteria and pathogens: Staphylococcus: Staphylococcus aureus and Staphylococcus epidermidis (thrombin positive and negative), including penicillin resistance Strain. Streptococcus: Group A beta hemolytic streptococcus, some non-hemolytic streptococci, and some pneumococci. Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Proteus mirabilis, Morgan morganiformis, most common Bacillus strains, Haemophilus influenzae, Moraxella lacunae, Haemophilus, Acinetobacter calcium acetate, and some Neisseria species.

Tobramycin and dexamethasone eye drops, the indications are: 1. ophthalmic inflammatory lesions that are responsive to adrenal corticosteroids and bacterial infections on the surface of the eye or are at risk of infection; 2. ophthalmic hormones for eyelids, Inflammatory diseases such as bulbar conjunctiva, cornea, anterior segment of the eyeball, and some infectious conjunctivitis that can accept the potential danger of hormones can reduce edema and inflammatory response. They are also suitable for chronic anterior uveitis, chemical, radioactive, burn and foreign body penetrating corneal damage; 3. Compound preparations with anti-infective ingredients can be applied to areas where there is a high risk of ocular surface infection and a large number of bacteria are expected When it is potentially dangerous to the eyes; the unique anti-infective drugs in this product are effective against some common eye bacteria and pathogens: Staphylococcus: Staphylococcus aureus and Staphylococcus epidermidis (thrombin positive and negative), including penicillin resistance Strain. Streptococcus: Group A beta hemolytic streptococcus, some non-hemolytic streptococci, and some pneumococci. Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Proteus mirabilis, Morgan morganiformis, most common Bacillus strains, Haemophilus influenzae, Moraxella lacunae, Haemophilus, Acinetobacter calcium acetate, and some Neisseria species.

Drug Name

Tobramycin Dexamethasone Eye Drops

Drug type

Prescription drugs, topical drugs, medical insurance workers' injuries

Special medicine

Doping

Use classification

Other ophthalmic drugs

Tobramycin dexamethasone eye drops ingredients

This product is a compound preparation, and its components are: tobramycin 15 mg and dexamethasone 5 mg / 5 ml.

Tobramycin Dexamethasone Eye Drops Properties

This product is white or almost white suspension liquid.

Tobramycin dexamethasone eye drops indications

1. Ophthalmic inflammatory lesions that respond to adrenocortical hormones and bacterial infections on the surface of the eye or situations at risk of infection;
2. Ophthalmic hormones are used for eyelids, bulbar conjunctiva, cornea, anterior segment of the eyeball and some inflammatory diseases such as infectious conjunctivitis, which can accept the potential danger of hormones, which can reduce edema and inflammatory response. They are also suitable for chronic anterior uveitis, chemical, radioactive, burn and foreign body penetrating corneal injuries;
3. Compound preparations with anti-infective ingredients can be applied to areas where there is a high risk of ocular surface infections and when a large number of bacteria are expected to be potentially dangerous in the eyes;
The unique anti-infective drugs in this product are effective against some common eye bacteria and pathogens:
Staphylococci: Staphylococcus aureus and Staphylococcus epidermidis (thrombin positive and negative), including penicillin-resistant strains.
Streptococcus: Group A beta hemolytic streptococcus, some non-hemolytic streptococci, and some pneumococci.
Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Proteus mirabilis, Morgan morganiformis, most common Bacillus strains, Haemophilus influenzae, Moraxella lacunae, Haemophilus, Acinetobacter calcium acetate, and some Neisseria species.

Tobramycin dexamethasone eye drops specifications

5ml: Tobramycin 15mg and Dexamethasone 5mg

Tobramycin and dexamethasone eye drops

1. Every 4 to 6 hours, 1 to 2 drops into the conjunctival sac each time. In the first 1-2 days the dose can be increased to once every 2 hours. Gradually reduce the frequency of medication according to the improvement of clinical signs, taking care not to stop treatment prematurely. Shake well before use.
2. The first prescription should not exceed 20 ml of eye drops.

Adverse effects of tobramycin and dexamethasone eye drops

1. Adverse effects of hormone and antibacterial drugs can come from hormone components, antibacterial components, or a combination of the two. There is no accurate data on the incidence of adverse reactions. Ophthalmic tobramycin (Tobax) may show a similar response to topical aminoglycoside antibiotics. The most common adverse reactions are local ocular toxicity and allergic reactions, including itchy eyelids, edema, and conjunctival congestion. These adverse reactions occur in less than 4% of patients. Other adverse reactions similar to those of other aminoglycoside antibiotics for ophthalmology have not been reported. However, if you use tobramycin in the eye when using aminoglycosides throughout the body, you should monitor the concentration of the drug in the serum;
2. Hormone-related adverse reactions are: increased intraocular pressure and may cause glaucoma, occasional damage to the optic nerve, cataract formation under the posterior capsule, and delayed wound healing;
3. Double infection: Double infection may occur after antibiotics and hormones are combined. Corneal fungal infections are prone to occur after long-term use of hormones. Fungal infections should be considered for refractory corneal ulcers following the use of hormones. Due to the host's immunosuppression, secondary bacterial infections of the eye may also result.

Tobramycin Dexamethasone Eye Drops Contraindications

1. Herpes simplex virus keratitis (dendritic keratitis), vaccinia, chicken pox and some corneal and conjunctival diseases caused by viral infections, mycobacterial infections in the eye, and fungal infections in the eye
2. Those who are allergic to any of the ingredients in this product;
3. Corneal foreign bodies are not completely removed.

Precautions for tobramycin dexamethasone eye drops

1. Cannot be used for eye injection. Some patients may be allergic to topical aminoglycosides and should be discontinued if allergies occur;
2. Long-term use of eye hormones can cause glaucoma, damage to the optic nerve, decreased vision, visual field defects, and cataract formation under the posterior capsule. Intraocular pressure should be monitored routinely during use, even for children and uncooperative patients who have difficulty measuring. Long-term use of hormones can suppress the host's immune response and may increase the chance of secondary serious eye infections. The use of hormones in some lesions that lead to thinning of the cornea and sclera may lead to the occurrence of eyeball perforation. In acute purulent lesions of the eye, hormones can mask the infection and exacerbate existing infections;
3. The possibility of corneal fungal infection should be considered after long-term use of hormones. Like other antibiotics, long-term use may lead to excessive growth of non-sensitive microorganisms, including fungi. Once a secondary infection occurs, appropriate treatment must begin. When multiple treatments are needed or when clinical judgment suggests a secondary infection, patients should be examined with fluorescein corneal staining and slit-lamp biomicroscopy;
4. Research and evaluation on carcinogenicity or mutagenicity of this product have not been conducted. In the study of subcutaneous injection of tobramycin 50mg and 100mg / kg / day in rats, no adverse effect on fertility was found;
5. The drug should be placed out of the reach of children.
6. Cross-allergy can occur with other aminoglycoside antibiotics.
7. To prevent the concentration of dexamethasone in the urine samples of athletes from exceeding the relevant regulations, athletes are advised to use this product with caution.
8. Do not touch the bottle mouth to the surface of any object, as this will contaminate the liquid in the bottle. Do not wear contact lenses while using this product.

Tobramycin and dexamethasone eye drops for pregnant and lactating women

Pregnant women:
Animal tests have shown teratogenic effects. In two trials of pregnant rabbits, the use of 0.1% dexamethasone in the eye resulted in 15.6% and 32.3% teratogenicity. In tests of long-term use of dexamethasone in rats, an increase in the incidence of fetal retardation and stillbirth was also observed. No evidence of adverse effects of tobramycin for parenteral application on fertility and fetal development was found in parenteral studies in rats and rabbits. There are insufficient or well-controlled studies in pregnant women. This product should only be used during pregnancy if the potential benefits outweigh the potential danger to the fetus;
Breastfeeding women:
Adrenal corticosteroids used throughout the body can be present in human milk and inhibit growth, affect endogenous adrenal corticosteroid production or cause other side effects. It is unclear whether topical application of this product excretes milk. Because many drugs can be excreted from human milk, this product should be used with caution in lactating women.

Tobramycin and dexamethasone eye drops for children

The safety and effectiveness of this product for children under 2 years of age have not been established.

Tobramycin and dexamethasone eye drops for elderly

This experiment was not performed and there are no reliable references.

Tobramycin dexamethasone eye drops drug interactions

This experiment was not performed and there are no reliable references.

Tobramycin dexamethasone eye drops overdose

The clinical signs and symptoms (spot keratitis, congestion, tearing, edema, and itching of the eyelids) may be similar to the adverse reactions in some patients. If this product is used in excess, the excess medicine can be washed away with running water.

Tobramycin Dexamethasone Eye Drops Pharmacology and Toxicology

1. Adrenocortical hormone can inhibit the inflammatory response caused by various factors, and may also delay wound healing. Adrenocortical hormones can inhibit the body's defense against infections. If this inhibition is of clinical significance, the combined use of antibiotics should be considered. Dexamethasone is a strong corticosteroid;
2. The antibiotic component (tobramycin) contained in the mixture has anti-sensitive microorganism activity. Experimental studies have shown that tobramycin is effective against the following microbial sensitive strains:
Staphylococci: Staphylococcus aureus and Staphylococcus epidermidis (thrombin positive and negative), including penicillin-resistant strains.
Streptococcus: Group A beta hemolytic streptococcus, some non-hemolytic streptococci, and some pneumococci. Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Proteus mirabilis, Morgan morganiformis, most common Bacillus strains, Haemophilus influenzae, Haemophilus escherichia, Lactobacillus mora Bacillus, Acinetobacter calcium acetate, and some Neisseria species;
3. The susceptibility test of bacteria showed that some gentamicin-resistant microorganisms were still sensitive to tobramycin. No significant resistance to tobramycin has been found. However, resistant bacteria may appear over time;
4. There is no data on the extent of systemic absorption after use of this product. However, we all know that there is a systemic absorption effect when the drug is applied topically to the eye. If used in the first 48 hours at the maximum dose (2 drops per eye every 2 hours) and complete systemic absorption (this is unlikely), equivalent to 2.4 mg of dexamethasone per day. The usual physiological replacement amount is 0.75 mg per day. If Dianbisu eye drops are 2 drops per eye every 4 hours in the first 48 hours, the amount of dexamethasone used will be 1.2 mg per day.

Pharmacokinetics of tobramycin dexamethasone eye drops

This experiment was not performed and there are no reliable references.

Tobramycin Dexamethasone Eye Drops Storage

Store at 8 27 .

Tobramycin Dexamethasone Eye Drops Packaging

(Packed in 5ml DROP-TAINER ^TM plastic drop bottle) 5ml / piece / box / piece

Tobramycin Dexamethasone Eye Drops Validity Period

24 months

Tobramycin dexamethasone eye drops implementation standard

Import drug registration standard JX20000341 ^[1]