What Are Inhaled Corticosteroids?

Inhaled glucocorticoids (ICS) are currently the most effective drugs for controlling airway inflammation. The available drugs are beclometasone propionate (BDP), budesonide (BUD), and fluticasone (FP) to quantify gas. Aerosol, dry powder or solution for inhalation.

Inhaled glucocorticoids

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Inhaled glucocorticoids (ICS) are currently the most effective drugs for controlling airway inflammation. The available drugs are beclometasone propionate (BDP),

When starting to use ICS, generally higher doses are given to quickly control asthma symptoms, which can be gradually reduced to the minimum maintenance dose after 3 to 6 months. For seasonal asthma, ICS can be given 2 weeks before the season, and the drug can be discontinued after the season. Consistent use of ICS and on-demand short-acting beta-agonist (SABA) as prescribed by your doctor will enable most patients with mild to moderate asthma to achieve complete and well-controlled goals.

ICS + long-acting 2 receptor agonist (LABA)

LABA is the strongest bronchodilator. ICS and LABA have different and synergistic effects on different aspects of asthma.

Clinical applications of LABA include salmeterol and flermodrol. The former has a slow onset of action, and the duration of action is not affected by the dose, while the latter has the characteristics of long-acting and quick-acting.

Currently, inhaled ICS and LABA are considered to be the most effective way to treat asthma. The combined inhalants of ICS and LABA, fluticasone / salmeterol and budesonide / flumodrol, are more widely used in clinical applications.

Although ICS plus LABA can significantly improve the control rate of asthma, some patients still need to use SABA as needed, and there is still a risk of acute exacerbation of asthma. To this end, Barnes of the British Heart and Lung Institute pointed out that using the same inhaler for budesonide / flumodrol maintenance + on-demand use of SABA treatment is more effective and convenient, which will help achieve the goal of asthma prevention and treatment.

ICS + Theophylline

Low-dose ICS + theophylline can relieve asthma symptoms, improve lung function, and reduce airway hyperresponsiveness in mild to moderate patients. When mild to moderate asthma patients can not control the symptoms by inhaling low doses of ICS, extended release theophylline can also be added.

ICS + leukotriene receptor modifier

Leukotriene receptor modifiers include zalulast and montelukast. Compared with low-dose ICS alone, low-dose ICS + montelukast can significantly improve lung function, reduce the symptoms of asthma during the day, and reduce the number of night awakening . But the latter is not as effective as ICS + LABA in treating chronic persistent asthma. In addition, this class of drugs may work better for some types of asthma, such as aspirin allergic asthma.