What Are Iron Injections?

Iron sucrose injection is used for patients who have poor oral iron and need intravenous iron treatment.

Iron sucrose injection is used for patients who have poor oral iron and need intravenous iron treatment.

Drug Name

Iron sucrose injection

Foreign name

Iron Sucrose Injection

Whether prescription drugs

prescription

Main indications

Patients who require poor oral iron treatment need intravenous iron treatment

Dosage

See below

Adverse reactions

Rare allergic reactions, etc.

Main medication contraindications

as follows

Dosage form

injection

Whether to include health insurance

Incorporate

Approval Number

National Medicine Standard H20057617

Drug type

Occupational injury medical insurance

Hanyu Pinyin

Zhe Tang Tie Zhu She Ye

Use classification

Iron agent

Iron sucrose injection composition

The main ingredient of this product is iron sucrose.
Chemical name: Iron hydroxide sucrose complex.
Chemical Structure:

Molecular formula: [Na ₂ Fe ₅ O ₈ (OH) · 3 (H ₂ O)] n · m (C ₁₂ H ₂₂ O ₁₁ )
Molecular weight: 34000 60000Da

Traits of iron sucrose injection

This product is a tan colloidal solution.

Indications of iron sucrose injection

This product is used in patients with poor oral iron and in need of intravenous iron ^[1] , such as:
Patients who can't tolerate oral ironPatients who can't absorb oral iron

Specification for iron sucrose injection

5ml: 100mg (iron)

Iron sucrose injection

Sucrose iron injection usage

This product can only be mixed with 0.9% w / v saline. This product cannot be mixed with other therapeutic drugs.
Visually inspect Aman for sedimentation and breakage before use. Use only those solutions that do not settle.
The container of this product should be used immediately after being opened:
If stored in sunlight at 4 ° C-25 ° C, the product diluted with 0.9% physiological saline should be used within 12 hours.
This product should be administered intravenously in the form of drip or slow injection, or directly into the intravenous end of a dialyzer. This drug is not suitable for intramuscular injection or a full-dose administration in accordance with the total amount of iron required by the patient.
Before the first treatment of a new patient, a small dose should be tested according to the recommended method. Adults use 1-2.5ml (20-50mg) iron, and children> 14 kg use 1ml (20mg iron). 14 kg children use half the daily dose (1.5 mg / kg). Cardiopulmonary resuscitation equipment should be available. If no adverse reactions occur after 15 minutes of administration, continue to administer the remaining solution.
Infusion :

The preferred method of administration of this product is infusion (to reduce the risk of hypotension and the risk of intravenous injection). 1ml of this product can only be diluted up to 20ml 0.9% w / v physiological saline, the diluted solution should be used immediately after preparation (eg: 5ml of this product is diluted up to 100ml 0.9% physiological saline, and 25ml of this product is diluted up to 500ml 0.9% w / v saline). The drip rate of the drug solution should be: 100mg iron for at least 15 minutes; 200mg for at least 1.5 hours; 400mg for at least 2.5 hours; 500mg for at least 3.5 hours.
If clinical needs, the volume of the 0.9% saline solution of this product can be less than a specific amount, formulated into a higher concentration of this product. However, the infusion rate must be determined according to the dose of iron given per minute (eg: 10ml of this product = 200mg of iron should be completed at least 30 minutes; 25ml of this product = 500mg of iron should be completed at least 3.5 hours). To ensure the stability of the medicinal solution, it is not allowed to formulate the medicinal solution into a more dilute solution.
Intravenous :

This product can be injected slowly without dilution. The recommended speed is 1ml of this product per minute (5ml of this product is injected for at least 5 minutes). The maximum injection dose per time is 10ml of this product (200mg iron). After intravenous injection, the patient's arm should be extended.
Inject the dialyzer :

This product can be directly injected into the intravenous end of the dialyzer, the situation is the same as the previous intravenous injection.

Dosage of iron sucrose injection

Calculate the total iron deficiency according to the following formula. Use this to determine the dosage for each patient:
Total iron deficiency [mg] = weight [kg] x (target value of Hb-actual value of Hb) [g / l] x 0.24 * + amount of stored iron [mg]
Weight 35kg: Hb target value = 130g / l iron storage capacity = 15mg / kg body weight> 35kg: Hb target value = 150g / l iron storage capacity = 500mg
* Factor 0.24 = 0.0034x0.07x1000
(Hemoglobin content is about 0.34% / blood volume is about 7% of body weight / factor 1000 means conversion from g to mg)
Total dose of this product (ml) = total iron deficiency [mg] / 20mg / ml

Total number of body weight given to this product

[kg] Hb60g / l Hb75g / l Hb90g / l Hb105g / l

Total dose of this product (ml)

If the total requirement exceeds the maximum single-dose dose, it should be administered in divided doses. If no changes in hematological parameters are observed 1-2 weeks after administration, the initial diagnosis should be reconsidered.

Iron sucrose injection to calculate iron supplementation in patients with blood loss and support for autologous blood donation

Calculate the dose of this product required to compensate for iron deficiency according to the following formula:
If you know the blood loss: Intravenous injection of 20mg of iron (= 10ml of this product) will increase hemoglobin equivalent to 1 unit of blood (= 400ml contains Hb 150mg / l).
The amount of iron to be added [mg] = the amount of blood loss units x200 or the amount of this product [mg] = the amount of blood loss units x10
If the Hb value drops: Use the previous formula and assume that the stored iron does not need to be stored again.
Iron supplement [mg] = body weight [kg] x (Hb target value-Hb actual value) [g / l].

For example: body weight 60kg, Hb difference = 10g / l => amount of iron to be added 150mg => 7.5ml of this product is required

Common dosage of iron sucrose injection

Adults and seniors :
According to the level of hemoglobin, two to three times a week, 5-10ml (100-200mg iron) each time, the frequency of administration should not exceed 3 times a week.
Children :
According to the level of hemoglobin, two to three times a week, each time 0.15ml per kg of this product (= 3mg iron / kg body weight).

Maximum tolerable single dose of iron sucrose injection

Adults and seniors :
At the time of injection: 10ml (200mg iron) of this product is given by injection for at least 10 minutes.
When infusion: If clinically required, a single dose can be increased to 0.35ml of this product / kg of body weight (= 7mg iron / kg of body weight), up to 250ml of this product (500mg of iron), should be diluted to 500ml 0.9% w / v In saline, drip for at least 3.5 hours, once a week.

Adverse reactions of iron sucrose injection

Rare allergic reactions.
The following adverse reactions are reported occasionally 1%: metallic taste, headache, nausea, vomiting, diarrhea, hypotension, elevated liver enzymes, spasms / leg spasms, chest pain, drowsiness, dyspnea, pneumonia, cough, itching, etc. .
Rarely, parasympathetic nerve excitement, gastrointestinal dysfunction, muscle pain, fever, rubella, facial flushing, swelling of the extremities, dyspnea, varicose veins and venous spasm occurred at the site of the infusion.

Iron sucrose injection contraindications

This product is banned in:
-Non-iron-deficiency anemia-Excessive iron or iron utilization disorders-People with known allergies to mono- or disaccharide iron complexes

Precautions for iron sucrose injection

1. This product can only be used in patients whose indications have been fully confirmed through appropriate examinations. (Eg: serum ferritin, hemoglobin, hematocrit, red blood cell count, red blood cell index-MCV, MCH, MCHC).
2. Parenteral iron can cause potentially fatal allergic reactions or allergic reactions. Mild allergic reactions should take antihistamines; severe allergies should be given adrenaline immediately.
3. Patients with bronchial asthma, low iron binding rate or folic acid deficiency should pay special attention to the occurrence of allergic reactions or allergic reactions.
4. Patients with severe liver dysfunction, acute infection, history of allergy or chronic infection should be careful when using this product.
5. If the injection speed of this product is too fast, hypotension will be caused.
6. Beware of extravenous leaks. If extravenous leaks are encountered, follow these steps: If the needle is still inserted. Wash with a small amount of 0.9% physiological saline. To speed up the removal of iron, instruct the patient to apply mucopolysaccharide ointment or ointment to the eye of the needle. Gently apply mucopolysaccharide ointment or ointment. Touching is prohibited to avoid further spread of iron.
7. This product will not affect driving and mechanical operation capabilities.

Iron sucrose injection for pregnant and lactating women

Animal reproductive toxicology studies have shown that this product does not cause animal deformities and miscarriages in non-anemic animals. However, parenteral iron is not recommended for the first 3 months and should be used with caution in the second and third phases. Any metabolites of this product will not enter the mother.

Iron sucrose injection for children

Parenteral use of iron can adversely affect infected children.

Iron sucrose injection

See the detailed description of [Usage and Dosage].

Iron sucrose injection drug interactions

Like all parenteral irons, this product reduces the absorption of oral irons. Therefore, this product cannot be used at the same time as oral iron. Therefore, oral iron treatment should be started 5 days after the injection of this product.

Iron sucrose injection drug overdose

Overdose can cause acute iron overload, manifested as methemia. Overdose should use an iron chelator in an effective way.

Sucrose iron injection pharmacology and toxicology

The surface of the polynuclear iron (III) hydroxide core is surrounded by a large number of non-covalently bound sucrose molecules, thereby forming a complex with an average molecular weight of 43 kDa. This macromolecular structure can be eliminated from the kidneys. This complex is structurally stable and does not release iron ions under physiological conditions. The structure of the multi-core core surrounded by iron is similar to the structure of ferritin under physiological conditions.
The use of this product will cause physiological changes in the human body, including the intake of iron.
This product has low toxicity. After intravenous administration of this product to white mice, the LD ₅₀ > 200 mg iron / kg body weight, so the therapeutic index is about 30 (200/7).

Pharmacokinetics of iron sucrose injection

A single dose of this product containing 100 mg of iron was intravenously administered to healthy volunteers, and the iron level reached the highest after 10 minutes, with an average of 538 mmol / l. The central compartment volume is equal to the plasma volume (approximately 3L).
The injected iron is rapidly cleared in the plasma, and the half-life is about 6 hours. The steady-state distribution volume is about 8L, indicating that iron is distributed in a small amount in body fluids. Because this product is less stable than transferrin, we can see the competitive exchange of iron to transferrin. Results The iron transfer rate was 31 mg iron / 24 h.
The renal clearance of iron in the first 4 hours after injection of this product is less than 5% of the total clearance. After 24 hours, the level of iron in plasma dropped to the level before the injection, and about 75% of sucrose was excreted.

Storage of iron sucrose injection

Keep tightly closed, shading, and store at room temperature (10-30 ° C).

Sucrose iron injection packaging

Brown glass ampoules, 5ml each, 5 per box.

Sucrose iron injection

24 months

Standard for iron sucrose injection

YBH25822005