What Are Progesterone Injections?

Progesterone injection is suitable for the treatment of menstrual disorders such as amenorrhea and functional uterine bleeding, luteal dysfunction, threatened abortion and habitual abortion (caused by luteal deficiency), and premenstrual stress syndrome.

Progesterone injection is suitable for the treatment of menstrual disorders such as amenorrhea and functional uterine bleeding, luteal dysfunction, threatened abortion and habitual abortion (caused by luteal deficiency), and premenstrual stress syndrome.

Drug Name

Progesterone injection

Drug type

Prescription medicines, essential medicines, medicines for medical workers' injuries

Use classification

Progestins

Progesterone injection ingredients

The main ingredients of this product are: Progesterone. Auxiliary materials: benzyl alcohol, soybean oil (for injection).
Chemical name: Pregn-4-en-3,20-dione.
Chemical Structure:

Molecular formula: C ₂₁ H ₃₀ O ₂
Molecular weight: 314.47

Properties of progesterone injection

This product is colorless to light yellow clear oily liquid.

Progesterone injection indications

For menstrual disorders, such as amenorrhea and functional uterine bleeding, luteal dysfunction, threatened abortion and habitual abortion (caused by luteal insufficiency), premenstrual tension syndrome.

Progesterone injection specifications

1ml: 20mg

Progesterone injection dosage

Intramuscular injection:
(1) Threatened abortion, usually 10-20 mg, until pain and bleeding stop;
(2) Those with a history of habitual abortion, starting from pregnancy, 10 to 20 mg once, 2 to 3 times per week;
(3) Functional uterine bleeding, used for withdrawal bleeding when hemoglobin is less than 7mg, 10mg a day for 5 days, or 20mg a day for 3 to 4 consecutive days;
(4) Amenorrhea, intramuscular injection of 10 mg daily for 5 days 8 to 10 days before the expected menstruation; or intramuscular injection of 20 mg daily for 3 to 4 days;
(5) Premenstrual stress syndrome, inject 10 to 20 mg 12 days before the expected menstruation for 10 consecutive days.

Adverse reactions to progesterone injection

Occasionally nausea, dizziness and headache, burnout, measles, breast swelling, long-term continuous application can reduce menstruation or amenorrhea, abnormal liver function, edema, weight gain, etc.

Progesterone injection contraindications

Patients with severe liver injury are contraindicated (aggravating symptoms).

Notes on progesterone injection

1. Use with caution in patients with kidney disease, heart edema, and hypertension.
2. The existence of progesterone deficiency in premenstrual tension is inconclusive, so the use of progesterone treatment is still controversial.
3 Patients other than early abortion should be thoroughly checked before administration to determine that they are luteal dysfunction before re-use.

Progesterone injection for pregnant and lactating women

still uncertain.

Progesterone injection for children

still uncertain.

Progesterone injection for the elderly

still uncertain.

Progesterone injection drug interactions

still uncertain.

Progesterone injection overdose

still uncertain.

Progesterone injection pharmacology and toxicology

This product is a progestin drug, which has the general effect of progestin. The endometrium secretion period can be changed at the later stage of the menstrual cycle, which provides favorable conditions for the implantation of pregnant eggs. After the fertilized eggs are implanted, the placenta is formed, which can reduce the excitability of the pregnant uterus and allow the fetus to grow safely. When combined with estrogen, it can promote breast development and prepare for milk production. This product can inhibit the release of luteinizing hormone from the anterior pituitary gland through negative feedback to the hypothalamus, prevent follicles from developing and mature, and inhibit the ovulation process of the ovary.

Pharmacokinetics of progesterone injection

Quickly absorbed after intramuscular injection from the injection. Metabolized in the liver, about 12% is metabolized to pregnanediol, and the metabolites are combined with glucuronic acid and excreted with urine. After injection of 100 mg, the blood concentration reached a peak in 6-8 hours, and then gradually decreased, which lasted for 48 hours and disappeared in 72 hours.

Progesterone injection storage

Protected from light and sealed (10-30 ° C).

Progesterone injection packaging

Colorless ampoule. 1 ml each, 10 pieces per box.

Validity of progesterone injection

36 months.

Progesterone injection standard

"Chinese Pharmacopoeia" 2010 edition two ^[1]