What Are the Medical Uses of Sodium Thiosulfate?
Sodium thiosulfate for injection, the indication is mainly used for cyanide poisoning, but also for arsenic, mercury, lead, bismuth, iodine poisoning.
- Drug Name
- Sodium thiosulfate for injection
- Drug type
- Prescription medicines, essential medicines, medicines for medical workers' injuries
- Use classification
- Cyanide poisoning antidote
- Sodium thiosulfate for injection, the indication is mainly used for cyanide poisoning, but also for arsenic, mercury, lead, bismuth, iodine poisoning.
Sodium thiosulfate for injection
- Chemical name: Sodium thiosulfate Molecular formula: Na 2 S 2 O 3 · 5H 2 0
Molecular weight: 248.19
Properties of sodium thiosulfate for injection
- This product is white granular powder.
Indications for sodium thiosulfate for injection
- Mainly used for cyanide poisoning, but also for arsenic, mercury, lead, bismuth, iodine and other poisoning.
Specification of sodium thiosulfate for injection
- (1) 0.32g (equivalent to 0.5g of Na 2 S 2 O 3 · 5H 2 O);
(2) 0.64g (equivalent to 1g of Na 2 S 2 O 3 · 5H 2 O)
Dosage of sodium thiosulfate for injection
- Immediately before use, dissolve into a 5% solution with sterile water for injection and apply.
Usual dose: 0.5 ~ 1g once intramuscularly or intravenously.
0.32g (equivalent to 0.5g of Na 2 S 2 O 3 · 5H 2 O); 0.64g (equivalent to 1g of Na 2 S 2 O 3 · 5H 2 O))
Adverse reactions of sodium thiosulfate for injection
- Except for temporary changes in osmotic pressure after intravenous injection of this product, no other adverse reactions have been seen.
Contraindications for sodium thiosulfate for injection
- Use with caution to those allergic to this product.
Precautions for sodium thiosulfate for injection
- (1) The volume of the vein once is too large. Pay attention to the general intravenous response.
(2) This product and sodium nitrite are used to treat cyanide poisoning from different detoxification mechanisms. They should be injected intravenously. They cannot be mixed and injected at the same time. Following the intravenous injection of sodium nitrite, this product is immediately injected from the original needle. Those who are orally poisoned need to lavage the stomach with a 5% solution and retain an appropriate amount in the stomach.
Sodium thiosulfate for injection for pregnant and lactating women
- This experiment was not performed and there are no reliable references.
Sodium thiosulfate for injection for children
- This experiment was not performed and there are no reliable references.
Sodium thiosulfate for injection
- This experiment was not performed and there are no reliable references.
Sodium thiosulfate drug interactions for injection
- The test was not performed and there are no reliable references.
Overdose of sodium thiosulfate for injection
- Overdose can cause dizziness, nausea, and fatigue.
Pharmacology and toxicology of sodium thiosulfate for injection
- The sulfur supplied by this product combines sulfur with CN- that is free in the body or has been bound to methemoglobin through sulfur transferase in the body, so that it becomes a less toxic thiocyanate, which is detoxified with urine excretion.
Pharmacokinetics of sodium thiosulfate for injection
- This product is not easily absorbed by the digestive tract. The extracellular fluid t 1/2 rapidly distributed to each tissue by intravenous injection was 15 to 20 minutes, and then excreted by urine.
Storage of sodium thiosulfate for injection
- Sealed and protected from light.
Packaging for sodium thiosulfate for injection
- 0.32g 7ml soda lime glass moulded bottle, 50 bottle carton 0.64g 7ml soda lime glass moulded bottle, 50 bottle carton
Shelf life of sodium thiosulfate for injection
- 36 months
Standard for sodium thiosulfate for injection
- Chinese Pharmacopoeia, 1963 edition [1]