What Are the Most Common Ceftriaxone Side Effects?

Ceftriaxone sodium for injection is used for lower respiratory tract infections, urinary tract and biliary tract infections caused by sensitive pathogens, as well as celiac infections, pelvic infections, skin and soft tissue infections, bone and joint infections, sepsis, meningitis, etc. and during surgery Infection prevention. A single dose of this product can treat simple gonorrhea.

Ceftriaxone sodium for injection is used for lower respiratory tract infections, urinary tract and biliary tract infections caused by sensitive pathogens, as well as celiac infections, pelvic infections, skin and soft tissue infections, bone and joint infections, sepsis, meningitis, etc. and during surgery Infection prevention. A single dose of this product can treat simple gonorrhea.

Drug Name

Ceftriaxone Sodium for Injection

Drug type

Work Injury Medical Insurance Class A Double Span

Use classification

Antibiotics

Ceftriaxone Sodium for Injection

It is strictly forbidden to be used in food and feed processing. This product cannot be used in solutions containing calcium such as Hartmann's and Ringer's.
The combination of this product with calcium-containing agents or calcium-containing products may cause adverse events of fatal outcome.

Ceftriaxone sodium for injection

Chemical name of ceftriaxone sodium: (6R, 7R) -7-[[(2-amino-4-thiazolyl) (methoxyimino) acetyl] amino] -8-oxo-3-[[(1, 2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl) thio] methyl] -5-thio-1-nitro Heterobicyclo [4.2.0] oct-2-ene-2-carboxylic acid disodium salt is trisemi-hydrate.
Chemical Structure:

Molecular formula: C ₁₈ H ₁₆ N ₈ Na ₂ O ₇ S ₃ · 3½ H ₂ O
Molecular weight: 661.59
Molecular weight: 661.59

Ceftriaxone Sodium for Injection

This product is white or off-white crystalline powder; odorless.

Ceftriaxone Sodium for Injection

It is used for lower respiratory tract infections, urinary tract infections, biliary tract infections caused by sensitive pathogens, as well as abdominal infections, pelvic infections, skin and soft tissue infections, bone and joint infections, sepsis, meningitis, and surgical infection prevention. A single dose of this product can treat simple gonorrhea.

Ceftriaxone sodium for injection

1.0g as C ₁₈ H ₁₈ N ₈ O ₇ S ₃

Ceftriaxone sodium for injection

Intramuscular injection or intravenous drip.
(1) Preparation of intramuscular injection solution: 3.6ml of sterile water for injection, sodium chloride injection, 5% glucose injection or 1% lidocaine hydrochloride is added to a 1g bottle to make 250mg ceftriaxone per 1ml The solution.
(2) Preparation of intravenous solution: 9.6ml of the aforementioned diluent (except lidocaine) was added to a 1g bottle to make a solution containing 100mg of ceftriaxone per 1ml, and then 5% glucose injection or chlorination was used. Sodium injection was diluted by intravenous injection at 100 250ml.
Adults usually use intramuscular or intravenous drip, 1 to 2 g every 24 hours or 0.5 to 1 g every 12 hours. The highest dose is 4g per day. The course of treatment is 7 to 14 days.
Commonly used intravenous drip in children, according to the weight of 20 to 80mg / kg a day. Adult dosage for children over 12 years.
The recommended dose for the treatment of gonorrhea is a single intramuscular injection of 0.25 g.

Ceftriaxone Sodium for Injection

Adverse reactions are related to the dose and duration of treatment. Local reactions include phlebitis (1.86%), in addition to rash, dermatitis, pruritus, urticaria, edema, fever, bronchospasm and serum sickness (2.77%), headache or dizziness (0.27%), soft stools, Gastrointestinal reactions such as diarrhea, nausea, vomiting, stomatitis, abdominal pain, colitis, jaundice, flatulence, taste disorders and indigestion (3.45%). About 19% of laboratory abnormalities, including 14% of hematological abnormalities, including eosinophilia, bleeding, thrombocytosis or reduction, and leukopenia. Liver and renal dysfunction were 5% and 1.4%. Other rare side effects include increased liver enzymes and oliguria.

Ceftriaxone Sodium for Injection

Those who are allergic to cephalosporin antibiotics are prohibited.

Ceftriaxone sodium for injection

1. An allergy test is required before administration.
2. Cross-allergic reactions: People who are allergic to one kind of cephalosporin or cephamycin may also be allergic to other cephalosporins or cephamycin. People allergic to penicillins, penicillin derivatives, or penicillamine may also be allergic to cephalosporins or cephalosporins. When cephalosporins are applied to penicillin-allergic patients, 5% to 10% of allergic reactions occur; if the immune response is measured, 20% of patients are allergic to cephalosporins.
3. When applying this product to penicillin allergic patients, the pros and cons should be fully weighed according to the patient's situation and then decided. People with penicillin anaphylactic shock or immediate response should not use cephalosporins.
4. People with a history of gastrointestinal diseases, especially those with ulcerative colitis, localized enteritis, or antibiotic-associated colitis (cephalosporins rarely produce pseudomembranous colitis) should be used with caution.
5. Due to the low toxicity of cephalosporins, patients with chronic liver disease do not need to adjust the dose when applying this product. Patients with severe liver and kidney damage or cirrhosis should adjust the dose.
6. In patients with renal insufficiency, creatinine clearance is greater than 5ml / min. When the daily dose of this product is less than 2g, no dose adjustment is required. Hemodialysis does not remove much of this product, and no additional dose is required after dialysis.
7. Interference to diagnosis: Patients who use this product can obtain false positive response when measuring urine glucose by copper sulfate method, but not affected by glucosidase method; blood urea nitrogen and serum creatinine may be temporarily increased; serum bile Red matter, alkaline phosphatase, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) can all be elevated.
8. When this product is used for deep gluteal muscle injection, each side cannot exceed 1g.
9. The freshly prepared solution is kept below 5 ° C for 24 hours, but can only be stored at room temperature for 6 hours.
10. This product and aminoglycoside drugs cannot be mixed in the same syringe for injection, they must be injected separately.
11. This product cannot be added to solutions containing calcium such as Hartmann's and Ringer's.
12. Waste medicine packaging should not be discarded randomly.

Ceftriaxone Sodium for Injection for pregnant and lactating women

Although the use of cephalosporins has not been reported in pregnant and lactating women, its application must be weighed against the pros and cons.

Ceftriaxone sodium for injection for children

Medication safety in neonates (those with a birth weight less than 2 kg) has not been determined. Newborns with jaundice or newborns with a severe tendency to jaundice should use this product with caution or avoidance.

Ceftriaxone Sodium for Injection

Unless the elderly patient is weak, malnourished or has severe renal impairment, the elderly do not need to adjust the dose of ceftriaxone.

Ceftriaxone sodium for injection drug interactions

1. Add erythromycin, tetracycline, amphotericin B, vasoactive drugs (m-hydroxylamine, norepinephrine, etc.), phenytoin, chlorpromazine, promethazine, vitamin B, Cloudiness will appear when vitamin C etc. Because there are many contraindications to this product, it should be administered separately.
2. Disulfiram-like reactions may occur in individual patients when drinking alcohol or taking alcohol-containing drugs during the application of this product. Therefore, drinking alcohol and taking alcohol-containing drugs should be avoided during the application of this product and in the next few days.

Ceftriaxone Sodium for Injection Overdose

still uncertain.

Ceftriaxone sodium for injection pharmacology and toxicology

This product is a third-generation cephalosporin antibiotic. Strong activity against Enterobacteriaceae bacteria. MIC ₉₀ between 0.12 0.25mg for Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Fluorodes citrate, Indole-positive Proteus, Provenida and Serratia / L. Enterobacter cloacae, Acinetobacter and Pseudomonas aeruginosa have poor sensitivity to this product. It has strong antibacterial effect on Haemophilus influenzae, Neisseria gonorrhoeae and Neisseria meningitidis, and also has good effects on hemolytic streptococcus and pneumococcus. The MIC for S. aureus is 2 to 4 mg / L. Methicillin-resistant Staphylococcus and Enterococcus are resistant to this product. Most B. fragiles are resistant to this product.

Pharmacokinetics of Ceftriaxone Sodium for Injection

After intramuscular injection of 0.5g and 1g of this product, the peak drug concentration ( _Cmax ) was reached after about 2 hours, which was 43mg / L and 80mg / L, respectively. The blood concentration 24 hours after intramuscular injection of 0.5 g was 6.0 mg / L, and the blood elimination half-life (T _{1 / 2} ) was 7.1 hours. Intravenous injection of 0.5 g within 1 minute, the peak plasma concentration (C _max ) was 150.9 mg / L, the plasma concentration after 24 hours was 9.9 mg / L, and the blood elimination half-life (T _{1 / 2b} ) was 7.87 hours. Intravenous injection of this product lg within 30 minutes, the peak plasma concentration (C _max ) at the end of the infusion was 150.7 mg / L, and the plasma concentration at 24 hours was 9.3 mg / L. After daily intramuscular injection of 15-20 mg / kg to patients with purulent meningitis, the average cerebrospinal fluid concentration at 6 hours was 5.16 mg / L, and the concentration at 12 hours was 2.3 mg / L. After intravenous infusion of 1 g of this product, the concentrations in bile 5 hours and 14 hours were 1600 mg / L and 13.5 mg / L, respectively. The protein binding rate was 95%. Ceftriaxone is not metabolized in the human body. About 40% of the drug is excreted from the biliary and intestinal tracts in its original form, and 60% is excreted from the urine. Probenecid cannot increase the blood concentration of this product or extend its half-life.

Ceftriaxone sodium for injection storage

Shaded, sealed and stored in a cool and dry place (not exceeding 20 ° C).

Ceftriaxone Sodium for Injection Packaging

Packaging material: injection bottle + medicinal halogenated butyl rubber stopper Packaging specification: 10 bottles per box or 1 bottle per box (with 10ml of sterile water for injection) or 1 bottle per small box.

Ceftriaxone Sodium for Injection

30 months

Ceftriaxone Sodium for Injection

"Chinese Pharmacopoeia" 2010 edition two

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