What Are the Most Common Uses for Ampicillin and Sulbactam?

Ampicillin-Sulbactam is suitable for -lactamase-producing Haemophilus influenzae, Moraxella catarrhalis, Neisseria gonorrhoeae, Staphylococcus, certain Escherichia coli, Klebsiella, and Proteus mirabilis Hepatobiliary system, urinary system, skin and soft tissue infections caused by Bacteroides fragilis, Acinetobacter, Enterococcus, etc. are particularly suitable for mixed infections of aerobic and anaerobic bacteria, especially abdominal infections and pelvic infections. This product is also effective against the above infections caused by ampicillin-sensitive bacteria. This product should not be used for infections caused by Pseudomonas aeruginosa, Citrobacter, Providencia, Enterobacter, Morganella and Serratia.

Ampicillin-sulbactam

Ampicillin-Sulbactam is suitable for -lactamase-producing Haemophilus influenzae, Moraxella catarrhalis, Neisseria gonorrhoeae, Staphylococcus, certain Escherichia coli, Klebsiella, and Proteus mirabilis Hepatobiliary system, urinary system, skin and soft tissue infections caused by Bacteroides fragilis, Acinetobacter, Enterococcus, etc. are particularly suitable for mixed infections of aerobic and anaerobic bacteria, especially abdominal infections and pelvic infections. This product is also effective against the above infections caused by ampicillin-sensitive bacteria. This product should not be used for infections caused by Pseudomonas aeruginosa, Citrobacter, Providencia, Enterobacter, Morganella and Serratia.

Chinese name

Ampicillin-sulbactam

Foreign name

Ampicillin-Sulbactam

Other name

Penicillane sulfone / ampicillin

[Adverse reactions] Adverse reactions include pain at the injection site, rash, occasional diarrhea, nausea, and transient increase in ALT and AST. In rare cases, exfoliative dermatitis and anaphylactic shock occur.

[Contraindications] It is contraindicated in those who are allergic to this product or to any drug of penicillin and sulbactam.

[Caution] See ampicillin sodium. A skin test of penicillin is required before application.

1. Ampicillin-Sulbactam can enter the fetus through the placenta. This product is also contained in breast milk.

2. When renal function declines, adjust medication according to plasma creatinine clearance (see dosing instructions).

3. This product is prone to rash in patients with mononucleosis, so it should not be used.

[Drug interactions] See penicillin and ampicillin.

1. Probenecid can reduce the excretion of ampicillin-sulbactam from the kidneys, so probenecid increases the plasma concentration and prolongs the excretion time.

2. When allopurinol is combined with ampicillin-sulbactam, the incidence of rash is significantly increased, so it should be avoided in combination with allopurinol.

3. Ampicillin-sulbactam and disulfiram (acetaldehyde dehydrogenase inhibitor) should not be combined.

[Dosing instructions] See ampicillin. In patients with renal insufficiency, the half-life is prolonged. When the plasma creatinine clearance is 30ml / min, 15-29ml / min, 5-14ml / min, the half-life is 1 hour, 5 hours and 9 hours, respectively. The dosing interval should be adjusted to once every 6-8 / hour, 12 / hour, 24 / hour.

[Usage and dosage] Deep intramuscular injection, intravenous injection or intravenous drip. Adults 1.5 to 3 g once, the dose includes ampicillin and sulbactam. Once every 6 hours, each dose is dissolved in 50 to 100 ml of an appropriate dilution solution and administered intravenously within 15 to 30 minutes. Intramuscular injection does not exceed 6g per day. The daily dose for intravenous administration of adults does not exceed 12 g (the maximum daily dose of sulbactam does not exceed 4 g). Children 100-200mg / kg daily, divided into doses.

[Formulations and specifications] Ampicillin-Sulbactam for injection: 750mg (Ampicillin 500mg, Sulbactam 250mg); 1.5g (Ampicillin 1.0g, Sulbactam 0.5g). ^[1]