What Are the Possible Side Effects of Chloramphenicol Eye Ointment?

Chloramphenicol eye ointment for the treatment of conjunctivitis, keratitis, eyelids caused by Escherichia coli, Haemophilus influenzae, Klebsiella, Staphylococcus aureus, hemolytic streptococcus and other sensitive bacteria Yuan Yan, trachoma and so on.

Drug Name: Chloramphenicol eye ointment

Drug type: Prescription drugs, external drugs
Use classification: Other ophthalmic drugs

Chloramphenicol eye ointment ingredients

The main ingredient of this product is chloramphenicol, and its chemical name is D-threo-(-)-N- [- (hydroxymethyl) --hydroxy-p-nitrophenethyl] -2,2-di Chloroacetamide.

Molecular formula: C ₁₁ H ₁₂ Cl ₂ N ₂ O ₅

Molecular weight: 323.13

Properties of chloramphenicol eye ointment

This product is light yellow or yellow ointment.

Chloramphenicol eye ointment indications

It is used to treat conjunctivitis, keratitis, blepharitis, trachoma, etc. caused by E. coli, Haemophilus influenzae, Klebsiella, Staphylococcus aureus, hemolytic streptococcus and other sensitive bacteria.

Chloramphenicol eye ointment specifications

(1) 1% (2) 3%

Chloramphenicol eye ointment dosage

Apply to the eyelids 3 times a day.

Chloramphenicol eye ointment adverse reactions

May have eye irritation, allergic reactions, etc.

Chloramphenicol eye ointment

Those who are allergic to this product are prohibited.

Chloramphenicol eye cream precautions

1. Long-term use (more than 3 months) can cause optic neuritis or optic papillitis (especially in children). Patients who use this product for a long time should make an eye examination in advance, and pay close attention to the patient's visual function and symptoms of optic neuritis, and discontinue the drug once it appears. Take vitamin C and vitamin B together.
2. Do not touch the mouth of the bottle when applying the eye. Tighten the bottle cap after use. Do not let the mouth of the bottle contact the skin to avoid contamination.

Chloramphenicol eye ointment for pregnant and lactating women

Although this product is used topically, chloramphenicol has a severe bone marrow suppression effect. Pregnant women and lactating women may cause serious adverse reactions in newborns and lactating infants. Therefore, pregnant women and lactating women should be used with caution.

Chloramphenicol eye ointment for children

Newborns and preterm infants are disabled.

Chloramphenicol eye ointment drug interactions

Antagonism can occur when combined with macrolide antibiotics such as lincomycin or erythromycin, so it should not be used in combination.

Chloramphenicol eye ointment pharmacology and toxicology

This product is a chloramphenicol antibiotic. It has a broad-spectrum antimicrobial effect in vitro, including aerobic Gram-negative and Gram-positive bacteria, anaerobic bacteria, Rickettsia, Borrelia, and Chlamydia. Bactericidal to the following bacteria: Haemophilus influenzae, Streptococcus pneumoniae, and Neisseria meningitidis. It has only antibacterial effect on the following bacteria: Staphylococcus aureus, Streptococcus pyogenes, Streptococcus grass green, Group B hemolytic streptococcus, E. coli, Klebsiella pneumoniae, Proteus mirabilis, Salmonella typhi, Paratyphoid Anaerobic bacteria such as Salmonella, Shigella, Bacteroides fragile. The following bacteria are generally resistant to chloramphenicol: Pseudomonas aeruginosa, Acinetobacter, Enterobacter, Serratia marcescens, Indole-positive Proteus, Methicillin-resistant Staphylococcus, and Enterococcus.
This product is a bacteriostatic agent. Chloramphenicol is fat-soluble, diffuses into the bacterial cells, and can be reversibly bound to the 50S subunit of the bacterial ribosome, which hinders the growth of the peptide chain (probably due to the inhibition of the transpeptidase), thus inhibiting the peptide chain Formation, thereby preventing protein synthesis.

Chloramphenicol eye cream storage

Sealed and stored in a cool place.

Chloramphenicol eye ointment grading

Chloramphenicol: L4, half-life 4h, the level of breast drug is very low, it will not cause obvious toxic and side effects to the baby, but it can cause sensitization to subsequent medication. This product is very toxic, especially for newborns and mild infections. ^[1]