What Are the Pros and Cons of Suppositories for Children?

Erythromycin suppository, the indication is 1. This product is used as an alternative medicine for the following infections in patients with penicillin allergies: acute tonsillitis, acute pharyngitis, sinusitis caused by hemolytic streptococcus and pneumococcus; etc. Causes scarlet fever and cellulitis; diphtheria and diphtheria carriers; gas gangrene, anthrax, tetanus, actinomycosis; syphilis; listeria etc. 2. Legionellosis. 3. Chlamydia and Mycoplasma pneumonia. 4. Urinary and genital infections caused by chlamydia and mycoplasma. 5. Chlamydia trachomatis conjunctivitis. 6. Neisseria gonorrhoeae infection. 7. Oral infections caused by anaerobic bacteria. 8. Campylobacter jejuni enteritis. 9. Pertussis and so on.

Erythromycin suppository, the indication is 1. This product is used as an alternative medicine for the following infections in patients with penicillin allergies: acute tonsillitis, acute pharyngitis, sinusitis caused by hemolytic streptococcus and pneumococcus; Causes scarlet fever and cellulitis; diphtheria and diphtheria carriers; gas gangrene, anthrax, tetanus, actinomycosis; syphilis; listeria etc. 2. Legionellosis. 3. Chlamydia and Mycoplasma pneumonia. 4. Urinary and genital infections caused by chlamydia and mycoplasma. 5. Chlamydia trachomatis conjunctivitis. 6. Neisseria gonorrhoeae infection. 7. Oral infections caused by anaerobic bacteria. 8. Campylobacter jejuni enteritis. 9. Pertussis and so on.

Drug Name: Erythromycin suppository

Drug type: Prescription drugs, external drugs
Use classification: Antibiotics

Erythromycin suppository ingredients

Erythromycin.

Erythromycin plug trait

This product is a white bullet-shaped suppository

Erythromycin suppository indication

1. This product is used as an alternative medicine for the following infections in patients with penicillin allergy: acute tonsillitis, acute pharyngitis, sinusitis caused by hemolytic streptococcus, pneumococcus, etc .; scarlet fever, cellulitis caused by hemolytic streptococcus; diphtheria And diphtheria carriers; gas gangrene, anthrax, tetanus, actinomycosis; syphilis; listeria and so on.
2. Legionellosis.
3. Chlamydia and Mycoplasma pneumonia.
4. Urinary and genital infections caused by chlamydia and mycoplasma.
5. Chlamydia trachomatis conjunctivitis.
6. Neisseria gonorrhoeae infection.
7. Oral infections caused by anaerobic bacteria.
8. Campylobacter jejuni enteritis.
9. Pertussis and so on.

Erythromycin suppository specifications

1.0.05g (50,000 units)
2.0.1g (100000 units)
3.0.2g (200000 units)

Erythromycin suppository dosage

Rectal administration. 0.2g each time, twice a day. Usage: Take out the medicine plug, use medicine delivery device to plug the medicine into the anus 2 cm deep, or wear a finger cot to deliver medicine.

Erythromycin Suppositories

1. Hepatotoxicity is rare. Patients may have fatigue, fever and abnormal liver function, and occasionally jaundice.
2. Allergic reactions are manifested as drug fever, rash, eosinophilia, etc., and the incidence is about 0.5% to 1%.
3. Other, occasional arrhythmia, oral or vaginal candidiasis infection.

Erythromycin suppository

1. Those who are allergic to erythromycin are disabled.
2. Disable patients with diarrhea.
3 Severe liver dysfunction is disabled.

Precautions for erythromycin suppository

1. When a patient is allergic or intolerant to one erythromycin preparation, he may be allergic or intolerant to other erythromycin preparations.
2. Disturbance to diagnosis: Erythromycin can interfere with the fluorescence measurement of the Higerty method, which makes the measured value of urinary catecholamines falsely increase. Measurements of serum alkaline phosphatase, bilirubin, alanine aminotransferase, and aspartate aminotransferase may all increase.
3. Due to the differences in the sensitivity of different bacteria to erythromycin, a drug sensitivity test should be performed.
4. If the temperature is too high, in order to prevent the suppository from becoming soft, it can be used for a while to cool in cold water before use. Can be used after cooking oil or lubricant.

Erythromycin suppositories for pregnant and lactating women

1. Erythromycin can enter the fetal circulation through the placenta, the concentration is generally not high, and there are no reports on the impact of the fetus in the literature, but the pros and cons should still be weighed when applied to pregnant women.
2. A considerable amount of erythromycin enters breast milk. Pros and cons should be considered when applying to lactating women.

Erythromycin suppositories for children

100,000 units (each containing 0.1 g of erythromycin) should be selected. For children, use 20-30 mg per kg of body weight per day or as directed by your doctor.

Erythromycin suppository drug interaction

1. Erythromycin can inhibit the metabolism of antiepileptic drugs such as carbamazepine and valproic acid, resulting in an increase in the latter's blood concentration and toxic reactions. The combination of erythromycin and fentanyl can inhibit the metabolism of the latter and prolong its action time. Erythromycin in combination with antihistamines such as astemizole or terfenadine can increase cardiotoxicity, and in combination with cyclosporine can increase the latter's blood concentration and produce renal toxicity.
2. Erythromycin has antagonistic effects on chloramphenicol and lincomycin, and it is not recommended to use them together.
3. This product is a bacteriostatic agent, which can interfere with the bactericidal efficacy of penicillin. Therefore, when a rapid bactericidal effect such as treatment of meningitis is needed, the two should not be used at the same time.
4. Long-term use of erythromycin in patients taking warfarin can lead to prolonged prothrombin time, which increases the risk of bleeding, especially in elderly patients. When the two must be used together, the dose of warfarin should be adjusted appropriately, and the prothrombin time should be closely observed.
5. In addition to dihydroxyprophylline, the same use of erythromycin and xanthine can reduce the liver clearance of aminophylline, leading to an increase in serum aminophylline concentration and / or an increase in toxic reactions. It is more likely to occur after six days of use, and the reduction in aminophylline clearance is proportional to the peak of erythromycin serum. Therefore, the dose of xanthines should be adjusted during and after the same course of treatment.
6. Combination of erythromycin and other hepatotoxic drugs may enhance liver toxicity.
7. High-dose erythromycin combined with ototoxic drugs, especially patients with impaired renal function may increase ototoxicity.
8. When combined with lovastatin, it can inhibit the metabolism of the latter and increase its blood concentration, which may cause rhabdomyolysis. When combined with midazolam or triazolam, it can reduce the clearance of both and enhance its effect.

Erythromycin suppository pharmacology and toxicology

This product is a macrolide antibiotic. It has antibacterial activity against staphylococci (except methicillin-resistant strains), streptococci and gram-positive bacteria in each group. Neisseria, Haemophilus influenzae, and Bordetella pertussis are also sensitive to this product. This product also has antibacterial effect on various anaerobic bacteria except B. fragile and Fusobacterium. It also has inhibitory effects on Legionella, Campylobacter fetus, certain Borrelia, Mycoplasma pneumoniae, Rickettsia and Chlamydia. This product can penetrate the bacterial cell membrane and reversibly bind to the 50S subunit of the bacterial ribosome near the donor site ("P" position), blocking the transfer of ribonucleic acid (t-RNA) to the "P" position, and also Blocking the displacement of the polypeptide chain from the accepting position ("A" position) to the "P" position, thereby inhibiting bacterial protein synthesis.

Erythromycin suppository pharmacokinetics

The maximum blood concentration of erythromycin suppository is 2.14 g / ml, and the peak time is 2 hours. After being absorbed, erythromycin is widely distributed in various tissues and body fluids in addition to cerebrospinal fluid and brain tissues, especially in liver, bile and spleen. The concentration is high in the kidney, lung and other tissues. , The concentration in bile can reach more than 10 to 40 times the blood concentration. The concentration in subcutaneous tissue is higher; the concentration in pleural, ascites, pus, etc. can reach effective levels. This product enters the prostate and seminal vesicles in a certain amount (approximately 33% of blood concentration), but does not easily penetrate the blood-cerebrospinal fluid barrier. It can enter fetal blood and be excreted into breast milk. The fetal blood drug concentration is 5% to 20% of the mother blood drug concentration, and the breast milk concentration can reach more than 50% of the blood drug concentration. The apparent volume of distribution is 0.9 L / kg. The protein binding rate is 70% to 90%. Free erythromycin is metabolized in the liver with a half-life (t _1/2 ) of 1.4 to 2 hours, and the half-life (t _1/2 ) of patients without urine can be extended to 4.8 to 6 hours. Erythromycin is mainly concentrated in the liver and excreted from the bile, and undergoes enterohepatic circulation. Blood or peritoneum is rarely cleared after dialysis, so no additional treatment is required.
Erythromycin suppositories can prevent or reduce the irritation of the gastrointestinal tract by erythromycin, and also avoid the first-pass effect of the liver that may occur with oral preparations.

Erythromycin suppository storage

Sealed and stored in a cool place.

Erythromycin suppository packaging

Material: aluminum-plastic packaging; Specification: 4 pcs / box

Erythromycin Suppository

2 years ^[1]