What Are the Side Effects of Naproxen?
Naproxen, chemical name: (+)-a-methyl-6-methoxy-2-naphthaleneacetic acid, also known as methanapr, and Xiaotongling.
Nepson
Right!
- Chinese name
- Nepson
- chemical name
- (+)-A-methyl-6-methoxy-2-naphthaleneacetic acid
- Therapeutic effect
- Endonuclease
- dose
- Oral dose is 0.2g once, 2 to 3 times a day
- Naproxen, chemical name: (+)-a-methyl-6-methoxy-2-naphthaleneacetic acid, also known as methanapr, and Xiaotongling.
- Mechanism and effect
- Similar to ibuprofen, it inhibits prostaglandin synthesis and inhibits endonucleases, polymerases and ligases of human lymphocytes, thereby reducing the integration of DNA and exerting anti-inflammatory effects. The drug has a long half-life (13-14 hours) and slow excretion. It is especially suitable for patients with severe morning stiffness. Combined with probenecid, it can prolong its half-life and blood concentration.
- Dosage: The oral dose is 0.2g once, 2 to 3 times a day; children 10-15mg / (kg.d), the maximum amount does not exceed 0.4g.
- Same as ibuprofen, it can also cause a burning sensation in the stomach and gastrointestinal bleeding. The incidence of ulcers is 18%. It induces asthma, bullous photosensitivity, optic neuritis, blurred vision, vision loss, edema, hemolysis. Anemia. Side effects can be reduced or eliminated after reduction or withdrawal. Ulcer disease, liver and kidney dysfunction, pregnant women, nursing mothers and infants should be used with caution.
- Naproxen slow-release agents such as unipran sodium, selotide, propidine, panodin, etc.
- Nepson has large side effects and should not be used in children.
- Naproxen is a scientific name, and many pharmaceutical companies produce this non-steroidal analgesic and anti-inflammatory drug. It has been on the market for nearly 30 years and is widely used in the treatment of arthritis.
- NIH's experimental research drugs, including Xelex and Neproxen, have been suspended on the 20th after they discovered serious side effects of the two drugs. The study began clinical trials with 2,625 patients in 2001, and was originally scheduled for a seven-year long-term follow-up. Breitner, one of the study leaders, said preliminary data showed that 70 of the subjects had a stroke and heart disease, 23 of whom died as a result, and the rate was 50% higher in the group taking patients with Nepson.
- Successive problems with these two drugs have forced the FDA to consider new regulations for such drugs. Prior to the disclosure of the same serious side effects of the painkiller Vioxx from Merck, Merck had previously Waukesha, like Nepson, has a heart-protecting effect to refute. Waukesha was forced to withdraw from the market at the end of September 2001. "It bothers us and our patients," said Gardner, a rheumatologist at the University of Washington. He said he would like to see more research data on the side effects of Nepson. "I'm not sure if it will be based on a Research will change the prescription. "