What Are the Signs of a Naproxen Overdose?

Naproxen sodium for injection, the indication is for the symptomatic treatment of fever and pain caused by various reasons. And often used in rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, tendonitis, neuralgia, rheumatism and other symptoms, especially suitable for the acute episode of the above diseases, but also can be used for primary menstrual pain and middle, Pain relief after minor surgery.

Naproxen sodium for injection, the indication is for the symptomatic treatment of fever and pain caused by various reasons. And often used in rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, tendonitis, neuralgia, rheumatism and other symptoms, especially suitable for the acute episode of the above diseases, but also can be used for primary menstrual pain and middle, Pain relief after minor surgery.

Drug Name

Naproxen Sodium for Injection

Drug type

prescription

Use classification

Carboxylic acids

Naproxen sodium for injection

Naproxen Sodium

Naproxen sodium for injection

This product is white or off-white loose bulk or powder.

Naproxen sodium for injection indications

This product is used for the symptomatic treatment of fever and pain caused by various reasons. And often used in rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, tendonitis, neuralgia, rheumatism and other symptoms, especially suitable for the acute episode of the above diseases, but also can be used for primary menstrual pain and middle, Pain relief after minor surgery.

Naproxen sodium for injection

0.275g (calculated based on naproxen sodium)

Naproxen sodium for injection

1. Intravenous injection: 0.275g for adults, 1-2 times a day. Just before use, dissolve in 0.9% normal saline and dilute to about 20ml. Slowly, the injection time should be no less than 3 minutes. Children's ml per kilogram of body weight or as prescribed by your doctor.
2. Intravenous infusion: 0.275g once for adults, 1-2 times a day, just before use, dissolve in 0.9% physiological saline and dilute to about 100ml, slowly instillation, infusion time is not less than 30 minutes. Pediatric weight of 5ml per kg or as prescribed by your doctor.

Naproxen sodium for injection

1. Itchy skin, shortness of breath, dyspnea, asthma, tinnitus, lower limb edema, burning sensation, indigestion, stomach pain or discomfort, constipation, dizziness, drowsiness, headache, nausea and vomiting, the incidence is generally 3% -9 %.
2. Blurred vision or visual impairment, hearing loss, diarrhea, oral tingling or pain, palpitation and sweating, etc., the incidence rate is 1% -3%.
3. Gastrointestinal bleeding, kidney damage (allergic kidney fire, renal papillary necrosis and renal failure, etc.) urticaria, allergic rash, mental depression, muscle weakness, bleeding or granulocytopenia, and liver function damage are rare, The incidence is 1% -3%.
4. There may be a burning sensation at the injection site.

Naproxen sodium for injection contraindications

Those who are allergic to non-steroidal anti-inflammatory drugs such as aspirin are contraindicated.

Precautions for Naproxen Sodium for Injection

1. Cross-allergies. People who are allergic to aspirin or other non-steroidal anti-inflammatory are also allergic to this product.
2. The following conditions should be used with caution: patients with coagulation or platelet dysfunction, asthma, heart dysfunction, coronary heart disease, myocarditis, hypertension, liver and kidney dysfunction, and the elderly. Patients with renal insufficiency should pay attention to observation when applying this product.
3. When using this product for a long time, pay attention to check liver, kidney function, blood and eye examination.
4. When using this product, symptoms of drowsiness, dizziness and depression should be used with caution.
5. Intravenous infusion should be slow, too fast can cause burning sensation along the vein.

Naproxen sodium for injection for pregnant and lactating women

Banned for pregnant and lactating women.

Naproxen sodium for injection for children

Use with caution in children and at lower doses than in adults.

Naproxen sodium for injection

Use this product with caution in elderly patients.

Naproxen sodium for injection drug interactions

1. This product can strengthen the anticoagulant effect of heparin and dicoumarin, and prolong the bleeding time.
2. When used together with aspirin or other salicylic acid preparations, there is no synergistic effect on the relief of symptoms.
3. This product can reduce sodium excretion and hypotensive effect of furosemide.
4. This product can inhibit the excretion of lithium with the urine, and increase the blood concentration of lithium.
5. Probenecid combined with this product can increase the plasma level of this product and significantly extend the plasma half-life of this product. Efficacy and toxic reactions increase at the same time, so it is not recommended for clinical use.

Naproxen sodium for injection overdose

still uncertain.

Pharmacology and Toxicology of Naproxen Sodium for Injection

This product is naproxen sodium salt, 1.1g is equivalent to 1g naproxen, is a non-steroidal anti-inflammatory antipyretic analgesic. It has strong anti-inflammatory, antipyretic and analgesic effects, and circulates in the plasma in the form of naproxen anion in the body. The mechanism of action is similar to that of naproxen, and it has a significant inhibitory effect on prostaglandin synthase, reducing the release of prostaglandins It even stopped, which played an anti-inflammatory, antipyretic and analgesic effect.
The results of the acute toxicity study of this product are: LD ₅₀ administered to mice = 0.992 + 0.014 g / kg, and LD ₅₀ administered intravenously = 0348 + 0.008 g / kg. There were no obvious visceral lesions in the dead animals.

Pharmacokinetics of Naproxen Sodium for Injection

It is reported in the literature that the plasma concentration of this product reaches a peak 15 minutes after intravenous injection, and the half-life (t _1/2 ) is 12-14 hours. When the therapeutic concentration is reached in the body, 99% of naproxen binds to plasma proteins, and 95% of this product is excreted from the urine as naproxen or the metabolite 6-oxo-desmethylnaproxen and their combinations. Can pass through the placenta and drain from milk. Does not affect the metabolism of various enzymes and has no accumulation in the body.

Naproxen sodium for injection storage

Keep out of shading and airtight, keep in cool and dark place.

Naproxen sodium for injection

Vial

Naproxen Sodium for Injection

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