What Are the Symptoms of a Codeine Overdose?

Codeine phosphate tablets, the indication is 1. antitussive, used for more frequent dry cough, if more sputum volume should be combined with expectorants. 2. Analgesic, for moderate or more pain. 3. Sedation for local or general anesthesia.

Codeine phosphate tablets, the indication is 1. antitussive, used for more frequent dry cough, if more sputum volume should be combined with expectorants. 2. Analgesic, for moderate or more pain. 3. Sedation for local or general anesthesia.

Drug Name

Codeine phosphate tablets

Drug type

Prescription medicines, essential medicines, medicines for medical workers' injuries

Special medicine

Narcotic Drugs

Use classification

Opioid receptor agonist

Codeine Phosphate Tablets Ingredients

The main ingredient of this product is codeine phosphate.
Chemical name: 17-methyl-3-methoxy-4,5-epoxy-7,8-didehydromorphinan-6-alcohol phosphate sesquihydrate Chemical structural formula:

Molecular formula: C ₁₈ H ₂₁ NO ₃ · H ₃ PO ₄ · 3 / 2H ₂ 0
Molecular weight: 424.39

Codeine Phosphate Tablet Properties

This product is a white tablet or a coated tablet.

Codeine Phosphate Tablets Indication

1. Antitussive, used for more frequent dry cough, such as a large amount of sputum should be combined with expectorants.
2. Analgesic, for moderate or more pain.
3. Sedation for local or general anesthesia.

Codeine Phosphate Tablets Specifications

15mg; 30mg

Codeine Phosphate Tablets Usage and Dosage

Usual adult dose: Oral, 15-30mg once, 30-90mg a day;
Extreme: Oral, 100mg once, 250mg a day.
Commonly used in children: analgesic, oral 0.5 to 1mg / kg once a day, 3 times a day.
The amount of antitussive is 1/2 to 1/3. Use with caution in newborns and infants.

Codeine phosphate adverse reactions

1. The more common adverse reactions are:
psychological abnormality or fantasy;
Breathing is weak, slow or irregular;
The heart rate is fast or slow or abnormal.
2. Rare adverse reactions:
Convulsions, tinnitus, tremor, or uncontrolled muscle movements;
hives; allergic reactions such as pruritus, rash or swelling of the face;
Depression and muscle rigidity.
3. Long-term application causes dependence. The tendency of common doses to cause dependence is weaker than other morphine drugs. Typical symptoms are goose bumps, loss of appetite, diarrhea, toothache, nausea and vomiting, runny nose, chills, sneezing, yawning, sleep disorders, stomach cramps, sweating, weakness, heart rate increase, emotional agitation, or unknown cause Of fever.

Codeine phosphate taboo

Patients who are allergic to this product are prohibited.

Precautions for codeine phosphate tablets

The following situations should be used with caution:
bronchial asthma;
Acute abdomen, when the diagnosis is not clear, it may be misdiagnosed by concealing the truth;
Gallstones can cause bile duct spasm;
Unexplained diarrhea, which can make intestinal motility weaken and reduce the symptoms of diarrhea, and is misdiagnosed;
craniocerebral trauma or intracranial lesions, this product can cause pupils to become smaller and blur clinical signs;
Prostate hypertrophy due to this product is prone to cause urinary retention and aggravate the disease;
Repeated administration can produce drug resistance and prolonged use is addictive.

Codeine phosphate tablets for pregnant and lactating women

This product can make the fetus addicted through the placenta and cause withdrawal symptoms such as excessive crying, sneezing, yawning, diarrhea and vomiting. Application of this product during childbirth can cause respiratory depression in newborns.
It can be excreted from breast milk and used with caution by lactating women.

Codeine phosphate tablets for children

The test was not performed and there are no reliable references.

Codeine phosphate tablets for elderly

The test was not performed and there are no reliable references.

Codeine phosphate drug interactions

1. When combined with anticholinergic drugs, this product can aggravate the adverse reactions of constipation or urinary retention.
2. When combined with methadone or other morphine drugs, it can aggravate central respiratory depression.
3. When combined with muscle relaxants, respiratory depression is more significant.

Codeine phosphate overdose

Overdose clinical manifestations are: dizziness, drowsiness, restlessness, insanity, pupil reduction such as needle tip, epilepsy, hypotension, slow heart rate, weak breathing, unconsciousness, etc.

Codeine Phosphate Pharmacology and Toxicology

It selectively suppresses the cough center of the medulla oblongata, and has strong and rapid antitussive effect. It also has analgesic effect, its analgesic effect is about 1/12 to 1/7 of morphine, but stronger than general antipyretic analgesics. Can inhibit the secretion of bronchial glands, can make sputum thick and difficult to cough, so it should not be used for patients with thick sputum.

Pharmacokinetics of codeine phosphate tablets

It is easily absorbed by the gastrointestinal tract after oral administration, and is mainly distributed in the lungs, liver, kidneys and pancreas. This product easily penetrates the blood-brain barrier and can penetrate the placenta. Plasma protein binding rate is generally around 25%. T _1/2 is about 2.5 to 4 hours. The analgesic effect time is 30 to 45 minutes, and the effect is the strongest between 60 and 120 minutes. The duration of action is 4 hours for analgesia and 4-6 hours for antitussive. Excreted by the kidneys, mainly glucuronic acid conjugates.

Codeine Phosphate Storage

Shaded and sealed.

Codeine Phosphate Tablets Packaging

Aluminum foil for pharmaceutical packaging, rigid PVC sheet for medicine. 10 pieces / 2 plates

Codeine phosphate expiration date

60 months

Codeine phosphate tablets perform standards

"Chinese Pharmacopoeia" 2010 edition two ^[1]