What Are the Uses of Adapalene Gel?

The main ingredient of this product is adapalene. Chemical name: 6- [3- (1-adamantyl) -4-methoxyphenyl] -2-naphthoic acid.
Chemical Structure:

Adapalene gel, the indication is suitable for the skin treatment of acne vulgaris whose main manifestation is acne, pimples and pustules. It can also be used to treat acne on the face, chest and back.

Drug Name

Adapalene gel

Drug type

Prescription drugs, topical drugs, work injury drugs

Use classification

Antikeratosis

Adapalene gel ingredients

The main ingredient of this product is adapalene. Chemical name: 6- [3- (1-adamantyl) -4-methoxyphenyl] -2-naphthoic acid.
Chemical Structure:

Molecular formula: C ₂₈ H ₂₈ O ₃
Molecular weight: 412.53

Adapalene Gel Properties

This product is a white milky viscous body.

Adapalene gel indications

This product is suitable for skin treatment of acne vulgaris, which is mainly manifested by acne, pimples and pustules. It can also be used to treat acne on the face, chest and back.

Adapalene gel specifications

0.1%.

Adapalene gel usage dosage

This product is used once a day. Clean the affected area before bedtime and use it after drying. Apply a thin layer to the affected area. For patients who must reduce or suspend medication, it can be resumed when it is confirmed that the patient has restored tolerance to adapalene. Do not use cosmetics that cause acne and shrinkage.

Adapalene gel adverse reactions

The most common adverse reactions of this product in the first 2 to 4 weeks of treatment are erythema, dryness, scaly, itching, burns, or tingling, and most of them are mild and moderate. Less common adverse reactions are sunburn, skin irritation, burning and irritation of the skin. Rarely, adverse reactions include acne swelling, dermatitis and contact dermatitis, eye edema, conjunctivitis, erythema, itching, skin discoloration, rash and eczema. If the adverse reaction is serious, the number of medications should be reduced or discontinued.

Adapalene gel contraindications

Those who are allergic to any component of adapalene or gel excipients are contraindicated.

Adapalene gel precautions

1. If allergies or severe irritation reactions occur, medication should be stopped. After determining the extent of the local stimulus response, patients can be guided to reduce the number of medications, temporarily stop or stop the medication completely.

2. During the use of this product, if exposed to sunlight, including ultraviolet light, the dose should be reduced to a minimum. For patients who are often exposed to strong sunlight and are allergic to sunlight, special care should be taken when exercising outdoors. When it is unavoidable in the sun, it is recommended to use sunscreen products and protective clothing on the treatment area; when the climate is extremely abnormal, if there is strong wind or cold, it may be irritating to patients receiving this product.

3. Avoid contact with eyes, lips, oral cavity, nasal mucosa, palate, and other mucosal tissues. This product should not be used on cuts, abrasions, eczema or sunburned skin. It should not be used on patients with severe acne, Suffering from eczema-like skin wounds. When using other vitamin A acid drugs or using "waxy" hair removal methods, this product should be avoided for treatment.

Adapalene gel for pregnant and lactating women

There is no report on the efficacy of this product in pregnant women. It is recommended not to use this product during pregnancy.

It is not known whether this product is secreted with milk. Because many drugs are secreted with milk, it is recommended that lactating women take care when using this product and do not apply it on the chest.

Adapalene gel for children

In pediatric patients under 12 years of age, its safety and effectiveness have not been determined.

Adapalene gel for the elderly

In clinical trials, the subjects were between 12 and 30 years of age, so it is unclear whether there is a difference between elderly people over 65 years and young people.

Adapalene gel drug interactions

No interaction has been found between this product and other drugs that may be used on the skin at the same time. But other retinoic acid drugs or other drugs with similar mechanism of action should not be used at the same time.

Adapalene has a stable chemical structure and is not easily decomposed in air and sunlight. Extensive animal and human studies have not found phototoxicity and photosensitivity. However, the safety of animals and humans when using adapalene when repeatedly exposed to sunlight or ultraviolet radiation is unknown. Avoid excessive sunlight and ultraviolet radiation when using this product. Adapalene has low transdermal absorption, so interaction with systemic medications is not possible. There is no evidence that the efficacy of oral medications such as contraceptives and antibiotics will be affected by the use of this product on the skin.

This product may have a slight local irritation, which can cause additional irritation when used with hair loss, shrinkage or irritating substances. Therefore, use other skin anti-acne medicines such as erythromycin (concentration <4%), clindamycin phosphate (1%) solution or benzoyl peroxide gel (concentration <10%) in the morning, and use it at night. This product can avoid the mutual degradation of drugs or the accumulation of stimulating effects.

Adapalene gel overdose

This product is for external skin use only. Excessive application does not result in faster or better results, and significant redness, scaling, or skin discomfort may occur.

Adapalene Gel Pharmacology and Toxicology

Pharmacological effects:

Adapalene is an retinoic acid compound that has been shown to have anti-inflammatory properties in in vivo and in vitro inflammation models. Adapalene has a stable chemical structure and is not easily decomposed in air and light. In terms of mechanism of action, adapalene binds to a specific retinoic acid nuclear receptor like retinoic acid. Unlike retinoic acid, adapalene does not bind to cytoplasmic receptors that bind to proteins.

It has been proved in dermal drug tests using animal models established in mice that adapalene can treat acne and has cell differentiation and value-added activity. The mechanism of action of adapalene is thought to reduce the formation of tiny acne by normalizing hair follicle epithelial cells.

Adapalene is superior to retinoic acid in standard anti-inflammatory analysis in vivo and in vitro. It can inhibit the chemotactic response of human polynuclear leukocytes, and can inhibit the metabolism of polymorphonuclear leukocytes by inhibiting the transformation of arachidonic acid into an inflammatory mediator through a lipid oxidation reaction. This shows that adapalene applied to acne affected areas can alleviate the inflammatory response mediated by cellular responses. Human clinical trials have shown that adapalene can relieve the inflammatory reactions of acne (such as pustules and pimples).

Toxicology research:

The oral LD50 of this product in mice and rats is greater than 10ml / kg. Long-term intake of this drug may cause some side effects related to excessive oral vitamin A. Carcinogenicity tests were performed at local doses of 0.3, 0.9, and 2.6 mg / kg / day in mice, and in oral doses of 0.15, 0.5, and 1.5 mg / kg / day in rats, that is, 4--75 times the maximum daily external dosage of humans. the study. In oral tests, the incidence of oocyte adenoma and thyroid cancer in female rats, and the incidence of benign adrenal medulla and malignant pheochromocytoma in male rats showed a positive linear correlation. There are no relevant photocarcinogenicity test results, but animal tests have shown that drugs that act similarly to adapalene (such as retinoic acid) increase the risk of cancer by exposure to ultraviolet or sunlight in the laboratory. Rats took adapalene 20 mg / kg / day orally without reproductive toxicity. Teratogenic effects occurred when rats and rabbits took oral adapalene up to the maximum recommended human dose of 24 and 48 times, respectively.

Adapalene gel pharmacokinetics

Adapalene's transdermal absorption rate is very low; in clinical trials, for long-term use of skin on large areas of acne, when the analytical sensitivity was 0.15ng / ml, the level of adapalene in plasma was too low to be detected.

Rats (intravenous, intraperitoneal, oral and dermal administration) and rabbits (intravenous, oral, and dermal administration) were treated with [sup] 14 [/ sup] C-labeled adapalene, with radioactive distribution in many tissues , Liver, spleen, adrenal and ovarian levels are highest. Adapalene is metabolized in animals mainly by oxygen-demethylation, hydroxylation, and binding reactions. Excreted mainly by bile.

Adapalene Gel Storage

Store below 25 ° C, but do not freeze.

Adapalene gel pack

High-density polyethylene medical hose, 30g each, 1 per box.

Adapalene gel expiration date

24 months.

Adapalene Gel Implementation Standard

State Drug Administration Standard YBH21192005