What Are the Uses of Cetirizine Syrup?

Cetirizine hydrochloride syrup,

Foreign name: Cetirizine Hydrochloride Syrup
Whether prescription drugs: prescription

Dosage form: Syrup
Drug type: chemical
Specifications: 120ml: 0.12g

Cetirizine Hydrochloride Syrup Ingredients:

Cetirizine hydrochloride chemical name: (±) -2- [2- [4-[(4-chlorophenyl) benzyl] -1-piperazinyl] ethoxy] acetic acid dihydrochloride.
Molecular formula: C ₂₁ H ₂₅ ClN ₂ O ₃ · 2HCl
Molecular weight: 461.81

Category: Cetirizine Hydrochloride Syrup

Chemicals & Biological Products >> Anti-Allergic Drugs >> H1 Receptor Blockers >> Piperazines

Cetirizine Hydrochloride Syrup Properties:

This product is colorless to slightly yellow clear and viscous liquid; it has an aromatic odor.

Cetirizine hydrochloride syrup indication

Allergic rhinitis, hives, pruritus, dermatology, otolaryngology

Cetirizine hydrochloride syrup usage and dosage

oral. Adults or children over 12 years: 10ml each time, once a day, or as directed by your doctor. If an adverse reaction occurs, it can be changed in the morning and evening, 5ml each time. Children 6-11 years old: Depending on the severity of the symptoms, the recommended starting dose is 5ml once daily or as directed by your doctor. Children 2-5 years old: The recommended starting dose is 2.5ml once daily or as directed by your doctor.

Adverse reactions of cetirizine hydrochloride syrup

1. A few patients may have headache, dry mouth, drowsiness, and emotional instability, but the incidence is very low. 2. Very few patients may develop allergic reactions such as rash, pruritus, nausea, vomiting, abdominal pain, and diarrhea. 3. So far, no adverse reactions such as arrhythmia, prolonged QT interval, ventricular tachycardia, and obesity have been found. However, observation and follow-up should be strengthened during the medication period (especially for long-term drug users).

Cetirizine hydrochloride syrup contraindications

Allergic to this product, pregnant and lactating women are prohibited.

Precautions for cetirizine hydrochloride syrup

1. Renal impairment should be halved. 2. Avoid using after drinking. 3. Use with caution by drivers, operating machines or aerial workers. 4. This product does not have a specific antagonist. Patients with severe overdose should immediately perform gastric lavage, use supportive therapy, and closely observe changes in the condition for a long time. 5. Take caution when taking sedatives at the same time.

Cetirizine hydrochloride syrup for pregnant and lactating women

Pregnant and lactating women should be disabled.

Cetirizine hydrochloride syrup for children

After oral administration, the product reached the highest blood concentration within 1 hour. In adult plasma, the half-life is about 10 hours, in children 6-12 years old, the half-life is 6 hours, and in children 2-6 years, it is 5 hours, so children with plasma metabolism are higher than normal adults. The dosage for children 2-12 years old can be found in [Usage and Dosage]. The safety and effectiveness of medication for children under 2 years of age have not been confirmed.

Cetirizine hydrochloride syrup for the elderly

Cetirizine is mainly metabolized by the kidneys, so patients with renal impairment may have toxic reactions. Because elderly patients have decreased renal function, care should be taken when choosing a dose, and renal function monitoring should also be performed.

Cetirizine hydrochloride syrup drug interactions

1. Combined with drugs that can inhibit the central nervous system (such as barbiturates, benzodiazepines, muscle relaxants, anesthetics, analgesics and phenothiazine sedatives) or tricyclic antidepressants, Causes severe drowsiness.

2. When combined with theophylline, the drug's clearance rate will decrease and the blood concentration will increase, which can increase the adverse reactions of this drug.

Pharmacological effects of cetirizine hydrochloride syrup

This product is an oral selective histamine H ₁ receptor antagonist. No obvious anticholinergic and serotonin effects, and the central inhibitory effect is small.
Toxicology research:
The results of the Ames test, human lymphocyte chromosome aberration test, mouse lymphoma test and rat micronucleus test were all negative.
Reproductive toxicity: The results of fertility and general reproductive toxicity tests in mice suggest that when cetirizine is administered orally at a dose of 64 mg / kg (based on body surface area, approximately 25 times the maximum daily oral dose recommended by adults), No damage to fertility. Mice, rats, and rabbits received oral doses of 96, 225, and 135 mg / kg (calculated based on body surface area, which are approximately equivalent to 40, 180, and 220 times the maximum daily oral doses recommended by adults, respectively). See teratogenic effects. However, there are no adequate and strictly controlled clinical research data on pregnant women. Because animal reproduction studies do not always predict the effects of the drug on humans, this product should only be taken during pregnancy if it is really needed. Oral administration of lactating mice (female mice) at a dose of 96 mg / kg (based on body surface area, which is equivalent to approximately 40 times the maximum daily oral dose recommended by adults in the clinic), may cause delayed weight gain in pups. Studies in Beagle dogs have shown that approximately 3% of the dose is excreted in milk. Cetirizine has been reported to be excreted from human milk, so this product is not recommended for lactating women.
Carcinogenicity: In carcinogenicity tests administered orally in rats for 2 consecutive years, the dose reached 20 mg / kg (based on body surface area, which is equivalent to approximately 15 times the maximum daily oral dose recommended by adults, or the maximum daily dose recommended by children in clinical practice). 10 times), no carcinogenicity was seen. In the carcinogenicity test of oral administration in mice for 2 consecutive years, the dose reached 16mg / kg (based on body surface area, which is equivalent to approximately 6 times the maximum daily oral dose recommended for adults, or 4 times the maximum daily dose recommended for children. ), Can cause an increase in the incidence of benign liver tumors in male animals; when the dose is 4mg / kg (converted based on body surface area, which is equivalent to approximately twice the maximum daily oral dose recommended by adults, or the maximum daily dose recommended by children), No increase in the incidence of liver tumors was seen. The clinical significance of these findings is unclear.

Pharmacokinetics of Cetirizine Hydrochloride Syrup :

According to reports in the literature, this product absorbs quickly, and the blood concentration can reach a peak within 30 to 60 minutes after oral administration of 10 mg, and its peak concentration is about 257 g / L. The area under the plasma concentration-time curve was 2.87 mg / L · h, the distribution volume was 30 to 40 L at steady state, and the protein binding rate was 93%. This product has a half-life of 7 to 10 hours. About 70% of the product is eliminated from the urine as the original drug, and about 10% is eliminated from the feces. Food can delay the peak time of this product's blood concentration by 1.7 hours and reduce the blood concentration by 23%.