What Are the Uses of Dexamethasone for Cancer?

Dexamethasone tablets, the indication is adrenal corticosteroids. Mainly applicable to allergic and autoimmune inflammatory diseases, such as connective tissue disease, severe bronchial asthma, dermatitis and other allergic diseases, ulcerative colitis, acute leukemia, malignant lymphoma, etc. This medicine is also used for the diagnosis of certain adrenal cortex diseases-dexamethasone inhibition test.

Drug Name: Dexamethasone tablets
Drug type: Prescription medicines, essential medicines, medicines for medical workers' injuries

Special medicine: Doping
Use classification: Hormonal antitumor drugs

Dexamethasone tablets ingredients

The main ingredients of this product are: dexamethasone.

Chemical name: 16-methyl-11, 17, 21-trihydroxy-9-fluoroprogestin-1,4-diene-3,20-dione

Molecular formula: C ₂₂ H ₂₉ FO ₅

Molecular weight: 392.5

Dexamethasone sheet traits

This product is a white tablet with a slightly sweet and bitter taste.

Dexamethasone tablets indications

Adrenal corticosteroids. Mainly applicable to allergic and autoimmune inflammatory diseases, such as connective tissue disease, severe bronchial asthma, dermatitis and other allergic diseases, ulcerative colitis, acute leukemia, malignant lymphoma, etc. This medicine is also used for the diagnosis of certain adrenal cortex diseases-dexamethasone inhibition test.

Dexamethasone tablets specifications

0.75mg

Dexamethasone tablets dosage

oral. The starting dose for adults is 0.75 to 3.00 mg (1 to 4 tablets) once, 2 to 4 times a day. The maintenance amount depends on the condition, about 0.75mg (1 tablet) per day.

Dexamethasone tablets adverse reactions

Large doses of this product are prone to cause symptoms of diabetes, osteoporosis, peptic ulcer and Cushing-like syndrome, and have a strong inhibitory effect on the hypothalamus-pituitary-adrenal axis. Complicated infection is the main adverse reaction.

Dexamethasone tablets contraindications

1. Patients with a history of allergies to this product and adrenal corticosteroids are contraindicated.
2. Hypertension, thrombosis, gastric and duodenal ulcers, psychosis, abnormal electrolyte metabolism, myocardial infarction, visceral surgery, glaucoma and other patients are generally not suitable for use. Weigh the pros and cons of using in special circumstances, but attention should be paid to the possibility of worsening the condition.

Dexamethasone tablets precautions

1. Patients with tuberculosis, acute bacterial or viral infections should use it with caution. If it is really necessary, they must be given appropriate anti-tuberculosis and anti-infective treatment.
2. After taking the medicine for a long time, reduce the dose gradually before stopping the medicine.
3. Use with caution in patients with diabetes, osteoporosis, cirrhosis, renal insufficiency, and hypothyroidism.

Dexamethasone tablets for pregnant and lactating women

1. Use in pregnant women can increase the incidence of placental insufficiency, neonatal weight loss, or stillbirth. Animal tests have teratogenic effects. Pros and cons should be weighed.
2. Nursing mothers who receive large doses should not breastfeed to prevent the drug from being excreted through the milk, causing adverse reactions such as infant growth inhibition and adrenal cortex function inhibition.

Dexamethasone tablets for children

If children use adrenocortical hormones, they must be very cautious, because hormones can inhibit the growth and development of children, if it is really necessary for long-term use, short-acting or intermediate-acting preparations should be avoided. Long-acting dexamethasone preparations should be avoided. And observe the changes in intracranial pressure.

Dexamethasone tablets for elderly

Easy to produce hypertension; elderly patients, especially women after menopause, are prone to osteoporosis.

Dexamethasone tablets drug interactions

1. Taken with barbiturates, phenytoin, rifampicin, the metabolism promoting effect of this product is weakened.
2. Combined with salicylic acid drugs, it can reduce the salicylate blood concentration.
3 Can reduce the effect of anticoagulants, oral hypoglycemic agents, the dose should be adjusted.
4 Combined with diuretics (except potassium-preserving diuretics) can cause hypokalemia, attention should be paid to the dosage.

Dexamethasone tablets pharmacology and toxicology

This product has more significant anti-inflammatory, anti-allergic and anti-shock effects than prednisone, and has a light effect on water and sodium retention and potassium excretion, and has a strong inhibitory effect on the pituitary-adrenal axis.
1. Anti-inflammatory effect: This product can reduce and prevent the tissue's response to inflammation, thereby reducing the manifestation of inflammation. Hormones inhibit the accumulation of inflammatory cells, including macrophages and leukocytes, at the site of inflammation, and inhibit phagocytosis, release of lysosomal enzymes, and synthesis and release of inflammatory chemical mediators. Can reduce and prevent the tissue's response to inflammation, thereby reducing the manifestation of inflammation.
2. Immunosuppressive effects: including preventing or suppressing cell-mediated immune responses, delayed allergic reactions, reducing the number of T lymphocytes, monocytes, and eosinophils, reducing the ability of immunoglobulins to bind to cell surface receptors, and Inhibiting the synthesis and release of interleukins, thereby reducing the transformation of T lymphocytes to lymphoblasts, and reducing the expansion of the primary immune response. Can reduce the immune complex through the basement membrane, and can reduce complement components and the concentration of immunoglobulin.

Dexamethasone Tablets Pharmacokinetics

This product is easily absorbed from the digestive tract, with a plasma half-life (t _1/2 ) of 190 minutes and a tissue half-life (t _1/2 ) of 3 days.
Plasma protein binding rate is lower than other corticosteroids.

Dexamethasone tablets storage

Shaded and sealed.

Dexamethasone Packaging

This product is packed in aluminum-plastic blister, with 12 pieces per board and 4 plates per box.

Dexamethasone tablets lactation grading

Dexamethasone: L3, a half-life amount of 3.3h in milk is not very likely to produce clinical benefit, unless long-term high-dose use ^[1]