What Are the Uses of Imiquimod Cream?

Imiquimod cream, adult genitalia and perianal genital warts.

Drug Name: Imiquimod cream
Drug type: Topical drugs

Hanyu Pinyin: Mi Kui Mo Te Ru Gao
Use classification: Immune enhancer

Imiquimod cream ingredients

The main ingredients and chemical name of this product are: imiquimod, 1- (2-methylpropyl) -1H-imidazole [4, 5-C] quinoline-4-amine.
Its structural formula is:

Molecular formula: C ₁₄ H ₁₈ N ₄
Molecular weight: 240.31

Imiquimod cream properties

This product is a white to milky cream with an emulsion base.

Imiquimod cream indications

Adult Genital and Perianal Condyloma Acuminatum.

Imiquimod Cream Specifications

250mg: 12.5mg (5%)

Imiquimod Cream Usage and Dosage

1. Take medication 3 times a week (Monday, Wednesday, Friday or Tuesday, Thursday, and Saturday) before bedtime. Use the medicine reasonably under the guidance of a doctor to give the best effect of this product. It is recommended to wash your hands before and after use. Imiquimod cream is packaged in single or multiple doses. Each pack of cream (or 250mg cream) can be applied to warts with an area of 20 cm ² to avoid excessive use of this product.
2. Before going to bed, take an appropriate amount of ointment, evenly apply a thin layer to the wart area, gently massage until the drug is completely absorbed, and retain it for 6-10 hours. Do not seal the area.
3. Do not take a bath 6-10 hours after applying the ointment; after 6-10 hours, wash the drug off the wart area with water or neutral soap.
4. Patients should continue to use the ointment until the warts are completely cleared; the warts are cleared as soon as 2-4 weeks, and usually cleared in 8-12 weeks.
5. Patients with mild erythema after administration can continue to use without stopping the drug; if the patient feels general discomfort or a more obvious local skin reaction (such as more obvious edema, erosion, pain, etc.), the drug should be discontinued Several times, continue to use the drug after the response is reduced. Do not take more than 16 weeks.

Imiquimod cream adverse reactions

Most patients did not have any adverse reactions during treatment. After several times of medication, the adverse reactions that may occur clinically are mostly mild to moderate local skin inflammation, such as erythema, edema, erosion, ulcers, desquamation, burning, pain, itching, etc .: occasionally low fever, the above symptoms stop Can be eliminated quickly after treatment. If the reaction is mild, you can continue to take the drug; if the reaction is severe, you should stop the drug and seek medical treatment.
According to foreign data reports, more than 1% of patients may have adverse reactions that may be related to mimemod cream, including: discomfort at the medication site: wart site reactions (burning, pigmentation, inflammation, itching, pain, rash , Sensitivity, ulcers, tingling, tenderness); reactions around the warts (bleeding, burning, itching, pain, tenderness); systemic reactions: fatigue, fever, flu-like symptoms: central and peripheral nervous system discomfort: headache; stomach Intestinal Discomfort: Diarrhea: Musculoskeletal Discomfort: Myalgia.

Imiquimod cream contraindications

Not yet known.

Precautions for Imiquimod Cream

Imiquimod cream has not been evaluated for the treatment of human papillomavirus infection in the urethra, vagina, cervix, rectum or anal canal, and is not recommended for the above indications.
Common local skin reactions with this product include erythema, erosion, peeling, and edema. In case of severe local skin reaction, apply cream and soap to the area to be washed off. After the skin reaction is reduced, imiquimod cream can be resumed. There is no clinical experience about using imiquimod cream for treatment of genital warts with other drugs. Therefore, after using any medicine or surgery to treat genital warts, it is recommended to use this product after the local wounds have recovered. Imiquimod cream has the potential to exacerbate skin inflammatory reactions.
Patients should follow these guidelines when using 5% imiquimod cream:
1. Locally unavailable dressing packages.
2. Avoid sexual contact (reproductive organs, anus, or mouth) during medication, including sexual life with condoms (whether imiquimod cream can effectively prevent the transmission of genital warts is unclear, and it may reduce contraception Set of effects).
3. It is recommended to wash off the medicine with neutral soap and water after 6-10 hours.
4. Those who have not performed circumcision. If genital warts occur in the foreskin, they should be cleaned after turning up the foreskin every day.
5. Seek medical attention if serious adverse reactions occur.
6. Use the medicine under the guidance of a doctor. Avoid using this product in localized areas and avoid contact with eyes, mouth, nose, etc.

Imiquimod cream for pregnant and lactating women

Medication during pregnancy: Teratotoxicity was not found in imiquimod in rats and white rabbits. Rats were given a teratogenic dose of 1 equivalent to 28 times the human dose (mg / m ² ) of imiquimod, and the offspring lost weight and delayed ossification. In the study of cyanosis toxicity, pregnant rats were given an equivalent of 8 times the human dose of imiquimod, and no serious adverse reactions were found in their offspring.
Whether topical application of imiquimod is excreted through milk is unknown.

Imiquimod cream for children

Safety and efficacy have not been established in patients under 18 years of age.

Imiquimod cream drug interactions

still uncertain.

Imiquimod cream overdose

Because imiquimod cream has little percutaneous reabsorption, it is not easy to cause systemic reactions. Animal studies have shown that the lethal dose of imiquimod given to the white rabbit's bare skin is much greater than 1600 mg / m ² . Sustained topical administration of excess imiquimod milk sounds exacerbates skin reactions. The most serious adverse reactions reported clinically are hypotension after oral administration of multiple doses of imiquimod> 200 mg. The adverse reactions disappear after oral or intravenous fluid replacement.

Imiquimod Cream Pharmacology and Toxicology

Imiquimod can induce a variety of cytokines and related products in the local area of the drug, thereby producing immune regulation and indirect antiviral effects. Imiquimod can effectively induce a variety of cytokines including -interferon (IFN-) and -tumor necrosis factor (TNF-) in vivo and in vitro. In vitro can induce human peripheral blood monocytes to produce the following kinds of cytokines: -interferon (IFN-), -tumor necrosis factor (TNF-), interleukin (IL-1, IL-1, IL-6, 8, 10), colony-stimulating factors (C-CSF, GM-CSF), and chemokine cytokines (MCP-1, MCP-1 ). After 1 hour of topical application of imiquimod cream (0.05 ug / cm2), the concentrations of IFN- and TNF- in the skin reached a peak.
Imiquimod's two metabolites, S-26704 and S-22770, have similar immune activity.
The maximum concentration of imiquimod cream was 18.3%, and it was administered at 1.0g / kg. A local toxicity test was performed on the skin of white rabbits. After continuous administration for one week, no obvious skin irritation was observed except for slight erythema formation. No sensitizing effect on guinea pig skin was found.
This product is not carcinogenic, mutagenic or teratogenic.
Skin tolerance tests show that imiquimod is non-irritating to human normal skin.

Pharmacokinetics of Imiquimod Cream

A single topical 5 mg [ ¹⁴ C] -labeled imiquimod cream study in 6 healthy subjects showed that [ ¹⁴ C] -labeled imiquimod was less percutaneously resorbed. With topical application of imiquimod, no radioactive matter was detected in serum (minimum detection limit: 1ng / ml), and radioactive matter in urine and feces was <0.9% of the radiolabeled amount.

Imiquimod Cream Storage

Protect from light and keep tightly closed at 25 ° C or lower.

Imiquimod Cream Packaging

Aluminum-plastic composite film, 250mg / bag.

Imiquimod cream expiration date

Tentatively set for two years.

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