What Are Tobramycin Eye Drops?

Tobramycin eye drops, this indication is suitable for local infection of external eyes and appendages caused by sensitive bacteria.

Drug Name: Tobramycin Eye Drops

Drug type: Prescription drugs, topical drugs, medical insurance workers' injuries
Use classification: Other ophthalmic drugs

Tobramycin eye drops ingredients

The main ingredient of this product is tobramycin, and its chemical name is O-3-amino-3-deoxy--O-glucopyranosyl-
(1 6) -O- [2,6-diamino-2,3,6-trideoxy--D-nuclear-hexapyranosyl- (1 4)]-2-deoxy-D- Streptomycin. Excipients: sodium chloride, benzalkonium chloride, sodium hyaluronate, disodium hydrogen phosphate, sodium dihydrogen phosphate.
Chemical Structure:

Molecular formula: C ₁₈ H ₃₇ N ₅ O ₉
Molecular weight: 467.52

Tobramycin Eye Drops Properties

This product is colorless to slightly yellow clear liquid.

Tobramycin eye drops indications

This product is suitable for local infection of external eyes and appendages caused by sensitive bacteria.

Tobramycin eye drops specifications

5ml: 15mg.

Tobramycin eye drops usage dosage

Drop in the eyelid. Mild to moderate infection: 1-2 drops at a time, once every 4 hours; Severe infection: 2 drops at a time, once per hour.

Adverse effects of tobramycin eye drops

Occasionally local irritation symptoms, such as: eyelid burning or swelling, conjunctival erythema, etc .; rare allergic reactions.

Tobramycin eye drops contraindications

Those who are allergic to this product and other aminoglycoside antibiotics are contraindicated.

Precautions for tobramycin eye drops

1. Patients with renal insufficiency, abnormal liver function, vestibular function or hearing loss, dehydration, myasthenia gravis or Parkinson's disease and elderly patients should be used with caution.
2. Cross-allergy: Patients who are allergic to an aminoglycoside antibiotic such as streptomycin and gentamicin may be allergic to this product. If an allergic reaction occurs, the drug should be discontinued immediately.
3. The application of this product may lead to excessive growth of resistant bacteria, and even cause fungal infection.
4. If the patient is receiving systemic administration of aminoglycoside antibiotics at the same time, the blood concentration of this product and aminoglycoside antibiotics should be monitored.
5. Ophthalmic preparations can be used for up to 4 weeks after activation.

Tobramycin eye drops for pregnant and lactating women

A small amount of this product is absorbed into the whole body's blood circulation after eye drops. Because a small amount of the absorbed part can pass through the placenta and can be secreted into breast milk, pregnant women should use it with caution. Breastfeeding women should suspend breastfeeding while using this product.

Tobramycin eye drops for children

Due to its potential nephrotoxicity and ototoxicity, it should be used with caution in children.

Tobramycin eye drops for elderly

Due to its potential nephrotoxicity and ototoxicity, it should be used with caution in elderly patients.

Tobramycin eye drops drug interactions

1. This product is used in combination with other aminoglycosides to increase ototoxicity, renal toxicity, and neuromuscular blockade. Hearing loss may occur, and deafness may still develop after stopping the medication; hearing damage may recover or be permanent. Neuromuscular blockade can lead to skeletal muscle weakness, respiratory depression, or paralysis (apnea). Anticholinergic drugs or calcium salts can help block recovery.
2. Combining this product with neuromuscular blocking drugs can aggravate neuromuscular blocking effects, leading to muscle weakness, respiratory depression or respiratory paralysis (apnea). Combined with plasma-based drugs such as dextran, sodium alginate, diuretics such as itanilic acid, furosemide and capreomycin, cisplatin, vancomycin, etc., or successive local or systemic applications can increase ototoxicity Renal toxicity, hearing loss may occur, and deafness may still develop after stopping the drug, and hearing damage may recover or be permanent.
3. The combination of this product with ceftiophen may increase renal toxicity.
4. This product combined with polymyxins can increase nephrotoxicity and neuromuscular blockade. Neuromuscular blockade can cause skeletal muscle weakness, respiratory depression or paralysis (apnea).
5. This product should not be used in combination with other nephrotoxic or ototoxic drugs or applied in order to avoid nephrotoxicity or ototoxicity.

Tobramycin eye drops overdose

The experiment was not performed and there are no reliable references.

Tobramycin Eye Drops Pharmacology and Toxicology

This product is an aminoglycoside antibiotic. The antibacterial spectrum is similar to gentamicin, and it is effective against Escherichia coli, Aeromonas, Klebsiella, Proteus mirabilis, some indole-positive Proteus, Pseudomonas aeruginosa, some Neisseria, some Gram-negative bacteria, such as Serratia acnes and Shigella, have antibacterial effect; this product has 3 to 5 times stronger antibacterial effect against Pseudomonas aeruginosa and is moderately sensitive to Gentamicin. Monascus is highly sensitive to this product. Among Gram-positive bacteria, Staphylococcus aureus (including -lactamase-producing strains) is sensitive to this product; Streptococcus (including Streptococcus pyogenes, Pneumococcus, Streptococcus faecalis, etc.) are resistant to this product. Anaerobic bacteria (Bacteroides), Mycobacterium tuberculosis, Rickettsia, viruses and fungi are also resistant to this product. The mechanism of action of this product is to bind to the bacterial ribosome 30S subunit and inhibit the synthesis of bacterial proteins.

Pharmacokinetics of Tobramycin Eye Drops

A small amount of this product is absorbed into the systemic blood circulation after eye drops.

Tobramycin eye drops storage

Shaded, sealed and stored in a cool and dark place (protected from light not exceeding 20 ° C).

Tobramycin Eye Drops Packaging

Polyethylene plastic bottle. 5ml per bottle, 1 bottle per box.

Tobramycin Eye Drops Validity Period

24 months

Tobramycin Eye Drops

"Chinese Pharmacopoeia" 2010 edition two ^[1]