What Is a Sufficient Colchicine Dose?

Colchicine tablets, the indication is to treat the acute attack of gouty arthritis and prevent the acute attack of recurrent gouty arthritis.

Colchicine tablets, the indication is to treat the acute attack of gouty arthritis and prevent the acute attack of recurrent gouty arthritis.

Drug Name

Colchicine tablets

Drug type

Prescription medicines, essential medicines, medicines for medical workers' injuries

Use classification

Granulocyte infiltration inhibitor

Ingredients for colchicine tablets

The main ingredient of this product is colchicine, which is an alkaloid.
Chemical name: N- (5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxo-benzo [] heptatriene-heptatriene-7 -Yl) acetamide.
Chemical Structure:

Molecular formula: C ₂₂ H ₂₅ NO ₆
Molecular weight: 399.44

Colchicine tablet properties

This product is a white tablet.

Indications for colchicine tablets

Treatment of acute attacks of gouty arthritis, prevention of acute attacks of recurrent gouty arthritis.

Colchicine tablets specifications

0.5mg

Colchicine tablets usage dosage

oral. Acute phase: Adults usually take 0.5 to 1 mg (1 to 2 tablets) every 1 to 2 hours until joint symptoms are relieved or diarrhea or vomiting occurs. The therapeutic amount is generally 3 to 5 mg (6 to 10 tablets). It should not exceed 6mg (12 tablets) within an hour, and 0.5-1.5mg (1 to 3 tablets) a day after 72 hours of discontinuation. Take it in divided portions for a total of 7 days. Prevention: Take 0.5 to 1 mg (1 to 2 tablets) a day in divided doses, but the course of treatment is discretionary. If adverse reactions occur, the drug should be discontinued at any time.

Adverse reactions of colchicine tablets

There is a significant correlation with dose size, and oral administration is safer than intravenous administration.
(1) Gastrointestinal symptoms: abdominal pain, diarrhea, vomiting, and loss of appetite are common early adverse reactions, the incidence rate can reach 80%, and severe cases can cause dehydration and electrolyte disturbance. Long-term users may develop severe hemorrhagic gastroenteritis or malabsorption syndrome.
(2) Muscle and peripheral neuropathy: Proximal muscle weakness and / or increased serum creatine phosphokinase. Peripheral axonal polyneuropathy can occur at the same time as muscle cells are damaged, which manifests as numbness, tingling, and weakness. Myoneuropathy is rare and often occurs in people who take gout for a long time and those who have mild renal insufficiency.
(3) Myelosuppression: thrombocytopenia, neutrophil decline, and even aplastic anemia can sometimes be life-threatening.
(4) Shock: manifested as oliguria, hematuria, convulsions, and disturbance of consciousness. Mortality is high, more common in older people.
(5) Teratogenicity: The fathers of two cases of Down syndrome infants reported in the literature are those with a long history of taking colchicine because of familial Mediterranean fever.
(6) Others: hair loss, rash, fever and liver damage.

Colchicine tablets contraindications

It is contraindicated in patients with hypomyeloplasia and renal and liver dysfunction.

Notes on colchicine tablets

(1) If vomiting, diarrhea and other reactions occur, the dosage should be reduced, and severe cases should be discontinued immediately.
(2) Be used with caution in patients with bone marrow hematopoiesis, severe heart disease, renal insufficiency, and gastrointestinal disorders.
(3) Blood tests and liver and kidney functions should be checked regularly during medication.
(4) Another female patient must not become pregnant during the medication and within a few weeks after the medication is stopped.

Colchicine tablets for pregnant and lactating women

This product can cause teratosis, and pregnant and lactating women are prohibited.

Colchicine tablets for children

This experiment was not performed and there are no reliable references.

Colchicine tablets for the elderly

The dose should be reduced for the elderly. Because the poisoning amount of this product is often related to its accumulated dose in the body, it is easy to cause accumulation poisoning when the renal excretory function decreases. This product also needs detoxification through the enterohepatic circulation. When the liver function is poor, the detoxification ability decreases, and it is easy to promote the toxicity.

Colchicine tablets drug interactions

(1) This product can cause reversible vitamin B12 malabsorption.
(2) This product can make the central nervous system inhibitory drug synergistic, and the sympathetic nerve drug's response is strengthened.

Colchicine tablets overdose

This product is a cell mitotic toxin, which is highly toxic. Once overdose lacks rescue measures, special attention must be paid to drug overdose.

Pharmacology and Toxicology of Colchicine Tablets

Colchicine changes cell membrane functions by binding to neutrophil tubulin subunits, including inhibiting chemotaxis, adhesion, and phagocytosis of neutrophils; inhibiting phospholipase A, reducing monocytes and cells Leukocytes release prostaglandins and leukotrienes; inhibit local cells to produce interleukins, etc., so as to control local joint pain, swelling and inflammation. Colchicine does not affect the formation, dissolution, and excretion of urate, so it has no effect on lowering uric acid. Acute gouty arthritis is effective 12-24 hours after oral administration, and 90% of patients disappear pain within 24 to 48 hours after taking the medicine.
Acute toxicity test results: The intravenous lethal dose (LD ₅₀ ) of rats was 1.6 mg / kg; the intravenous LD ₅₀ of mice was 4.13 mg / kg.

Pharmacokinetics of colchicine tablets

It is quickly absorbed in the gastrointestinal tract after oral administration, and the plasma protein binding rate is low, only 10% to 34%. The blood drug concentration reaches a peak within 0.5 to 2 hours after taking the medicine. The peak of 2mg orally was 2.2ng / ml. The concentration of the drug in the isolated neutrophils is higher than the plasma concentration and can be maintained for up to 10 days. This product is metabolized in the liver and excreted from bile and kidney (10% to 20%). Patients with liver disease have increased excretion from the kidneys. Drug excretion lasted about 10 days after discontinuation.

Storage of colchicine tablets

Shaded and sealed.

Packaging of colchicine tablets

Packed in plastic bottles, 100 tablets per bottle; Packed in plastic bottles, 20 tablets per bottle.

Validity of Colchicine Tablets

24 months

Implementation of colchicine tablets

"Chinese Pharmacopoeia" 2010 edition two ^[1]