What Is Acebutolol?

Acetaminophen has competitive effects on the inhibition of catecholamines by the adrenergic beta receptor site. Pharmacological effect is similar to propranolol, but weaker. Long-lasting effect, T1 / 2 is 3-8 hours. By weakening or preventing receptor excitement, the contractile force and contraction speed of the heart are reduced, and the conduction speed of the conduction system is slowed, so that the heart's response to exercise or stress is weakened. Therefore, it is used in the treatment of angina pectoris to reduce myocardial oxygen consumption and increase exercise tolerance. Adrenaline is used to treat cardiac arrhythmias because it blocks excitatory adrenaline. It is possible that this product lowers blood pressure through central, adrenergic neuron block, antirenin activity, and reduced cardiac output, and is suitable for treating hypertension. Because this product can antagonize the catecholamine effect, it is also used to treat pheochromocytoma and hyperthyroidism, so that the activities of 1 and 2 receptors are in an inhibited state.

Chinese name: Acebutolol
Foreign name: Acebutolol

Chinese alias: Acetobutanol
English alias: Acecor, Monitan, Neptal
CAS: 37517-30-9

Acetaminophen Basic Information

Chinese name:

Chinese alias: acetobutanoic acid; N- [3-acetyl-4- (2-hydroxy-3-isopropylaminopropoxy) phenyl] butanamide;

English name: acebutolol

English alias: N- (3-Acetyl-4- (2-hydroxy-3- (isopropylamino) propoxy) phenyl) butyramide; Acebutolol; Acebutolol, (±)-;

CAS number: 37517-30-9

Molecular formula: C ₁₈ H ₂₈ N ₂ O ₄

Molecular weight: 336.42600

Exact mass: 336.20500

PSA: 87.66000

LogP: 2.82940

The physical and chemical properties of acebutolol

Appearance and properties: crystal

Density: 1.118g / cm ³

Melting point: 119-123ºC

Boiling point: 564.1ºC at 760 mmHg

Flash point: 295ºC

Refractive index: 1.542

Storage conditions: storeroom ventilated, low temperature and dry ^[1]

Instruction for acebutrolol

The name of fenbutrolol classification

Primary Category: Circulatory Drugs Secondary Category: Antihypertensive Drugs Third Category: Beta Receptor Blockers

Acetaminophen drug English name

Acebutolol

Acetaminophen drug alias

Butyroyl, Acecor, Monitan, Neptal

Acebutalol drug dosage form

1. Tablet: 400mg; 2. Capsule: 200mg; 3. Injection: 25mg.

Pharmacological effects of acebutolol

This product is a long-acting 1 receptor blocker. Its action intensity is 1/5 to 1/10 of propranolol. The sympathomimetic activity is 2 to 3 times the dose of -blocker. It slows down the resting heart rate than propranolol. Medicine Quan. Online www.med126.com The drug has a weaker myocardial inhibitory effect than propranolol, and its effect on peripheral vascular resistance is not obvious. A moderately lipophilic drug, acebutolol has no significant effect on normal human metabolism.

Acetonolol pharmacokinetics

Intestinal absorption, peak plasma concentration in 2 to 4 hours. 84% bound to plasma proteins. The half-life in plasma is 3-6 hours. Its metabolite diacetalol has selective -receptor blockade and its elimination half-life in plasma is more than 12 hours.

Acebutrolol indication

For hypertension and arrhythmia.

Contraindications of acebutrolol

Acebutolol See also: propranolol

Acebutrolol adverse reactions

Adverse reactions are minor, but the cardiac function is obviously impaired, and those with high atrioventricular block should not be used.

Acebutolol dosage

Oral: Start with 400 mg each time, once a day; if necessary, increase to 400 mg each time, twice a day.

Acebutolol drug interactions

Expert review

See propranolol. ^[2]