What Is Alfuzosin?

Alfuzosin is used to treat hypertension and some functional symptoms of benign prostatic hyperplasia.

Alfuzosin

Alfuzosin treatment
For people over 75 years of age, the drug is absorbed faster and has a higher peak. The bioavailability of the drug may increase, and the volume of distribution of some patients may decrease. But the elimination half-life of the drug remains the same.
In the case of renal insufficiency (dialysis or undialysis), as the free portion of this product increases, its diffuse volume and clearance rate will also increase. It has no adverse effects on chronic renal insufficiency or even severe renal insufficiency (creatinine clearance is 15-40ml per minute). Chronic cardiac insufficiency does not affect the pharmacokinetics of this product.
(1) Treatment
(1) Treatment of hypertension: Take 2.5mg of this product orally and maintain the antihypertensive effect for at least 12 hours. The average daily amount of long-term treatment is 7.5 ~ 12.5mg, twice a day.
(2) Treatment of benign prostatic hyperplasia: 1 tablet (2.5mg) each time, 3 times a day. All elderly patients (over 65 years of age) should use this medicine with caution, that is, the initial dose should be 1 tablet each morning and evening, up to 10 mg per day.
(3) For patients with renal insufficiency, for the sake of caution, the initial dose is 1 tablet (2.5 mg) each time, twice a day, and then the dose is adjusted according to the clinical response.
(4) The dosage of patients with mild and moderate liver dysfunction starts from 1 tablet (2.5 mg) once a day, and then increases to 1 tablet (2.5 mg) each time according to the clinical response.
[Formulations and specifications] capsules or tablets: 2.5mg per capsule.
This product is contraindicated in patients allergic to alpha-blockers.
Patients who are taking antihypertensive drugs should use this product with caution. For coronary heart patients, this product should not be taken alone, and special treatment of coronary insufficiency should be continued. This product should be discontinued if angina recurs or worsens.
When using large doses or for patients with hypertension, orthostatic hypotension may occur within hours after taking the medication, and some aura symptoms (dizziness, fatigue, sweating) may occur earlier. In this case, the patient should lie down until these symptoms have completely disappeared. These effects are temporary and usually do not affect continued treatment after reducing the dose. Patients should be explained in advance about these possible symptoms.
The following adverse reactions are common:
Gastrointestinal disorders (nausea, stomach pain, diarrhea), fainting (vertigo, dizziness or fainting), headache.
The following phenomena are rare:
Dry mouth, tachycardia, chest pain, weakness, drowsiness, rash, itching, flushing of the face.
Combined with the following drugs may cause severe drug interactions and cause hypotension: other -blockers such as prazosin, terazosin, etc .; calcium antagonists such as axandridine, double Phenylethylamine, thiazezone, isoptin, nitropyramide methyl, nitrpyrimidine methyl.
Patients taking this product can cause blood pressure instability during general anesthesia.

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