What Is Antidepressant Discontinuation Syndrome?
The purpose of medication is to prevent and treat diseases. After the purpose is achieved, it is natural to stop medication. However, improper discontinuation of drugs often causes "bounce phenomenon", "withdrawal phenomenon" and "discontinuation crisis", which are collectively referred to as "discontinuation syndrome" in clinical practice. Proper discontinuation is an important part of rational drug use. The presence or absence of discontinuation syndrome is an important criterion for judging whether discontinuation is appropriate.
Discontinuation syndrome
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- Chinese name
- Discontinuation syndrome
- Nature
- medicine
- Category
- disease
- Symptom
- Disturbance of consciousness, poor orientation, etc.
- The purpose of medication is to prevent and treat diseases. After the purpose is achieved, it is natural to stop medication. However, improper discontinuation of drugs often causes "bounce phenomenon", "withdrawal phenomenon" and "discontinuation crisis", which are collectively referred to as "discontinuation syndrome" in clinical practice. Proper discontinuation is an important part of rational drug use. The presence or absence of discontinuation syndrome is an important criterion for judging whether discontinuation is appropriate.
- The benefits of timely discontinuation are obvious. First, it prevents accumulation of poisoning. Such as the application of emmetine in the treatment of amoebic liver abscess, the medication is too long, the accumulation in the body is too large can occur in severe degenerative myocarditis, heart rhythm disorders, heart failure and even death. Vitamins such as vitamin A should not be taken blindly for a long time although they are less toxic, otherwise they will cause imbalance of vitamins in the body, affect normal body functions, and even cause poisoning. Second, it prevents drug dependence and addiction. Sedative drugs such as diazepam, rimienin, and methionine can produce reliance for long periods of time. The duration of medication should not exceed two months, and the medication should be changed if necessary. It is well known that narcotic analgesics morphine and dulentin are prone to addiction. Tolerance can be produced for 1 week after continuous medication, and addiction can be caused for more than 10 days. Therefore, such analgesics should not be used continuously for more than 5 days, and the next use must be separated by 10 days. In addition, antidepressants, central nervous system stimulants, and hypnotics can be drug-dependent. Sudden discontinuation of barbiturate hypnotics and biguanide antihypertensive drugs for a long time can cause a rebound phenomenon, which should be gradually reduced. Finally, it prevents drug-borne diseases. Such as chlorpromazine long-term high-dose medication can cause mental disorders. It manifests as disturbance of consciousness, poor orientation, hallucinations, hallucinations, and insanity. The drug should be discontinued or switched to other drugs in time. The long-term use of tetracycline-type broad-spectrum antibiotics can cause vitamin C, B, and calcium deficiency and imbalance of flora in the body, which can cause secondary infection. Chloramphenicol may cause aplastic anemia when administered for more than two weeks. Sulfonamides and phenobarbitals can easily cause allergic reactions such as rash and drug fever.
- How can we avoid the occurrence of withdrawal syndrome? If you are taking medicine, you should take it on time to avoid eating and stopping. If you have been taking a medicine for a while and you want to stop it now, you should take a gradual reduction. Generally, you can refer to the following method: first reduce the amount of medicine by 1/4 and maintain it for 1 week; then subtract 1/4 of it and maintain it for 1 week, and reduce it by 1/4 for the third time; the last 1/4 amount must be maintained at 1 The drug was discontinued for 2 weeks depending on the situation. The method of reducing drug withdrawal is to make the body gradually self-regulate in getting rid of dependence on the action of the drug, so as to avoid the unsuitable state caused by sudden drug withdrawal.