What Is Carvedilol?

Carvedilol high concentration can block calcium channels. It causes dilation of two capillaries through 1 receptor blocking and non-selective receptor blocking, reducing peripheral resistance and lowering blood pressure. Carvedilol's vasodilation effect is mainly due to the blocking effect of 1 receptor. Some metabolites also have beta receptor blocking effects. These metabolites also have a weak vasodilation effect.

Basic Information

Drug Name: Carvedilol
Alias: 1- (9H-carbazole-4-oxy) -3- [2- (2-methoxyphenoxy) ethylamino] -2-propanol

Foreign name: Carvedilol
Registration number: CAS [72956-09-3]; MI14,1873
Character: The product is a white tablet

Carvedilol Indication

For symptomatic heart failure. It is also used for essential hypertension.

Carvedilol Clinical Application

1. Treatment of heart failure: Oral: Start 3.125mg / time, 2 times / day, if well tolerated, increase to 6.25mg / time after 2 weeks, 2 times / day, gradually increase; weight less than 85 kg, maximum dose 25mg / Time, 2 times / day; body weight greater than 85 kg, maximum dose 50mg / time, 2 times / day.

2. For hypertension: Oral: Start at 12.5mg / time, 1 time / day, 2 days later can be added to 25mg / time, 1 time / day; if necessary, it can be added to the maximum amount of 50mg / day after 2 weeks, min Take 1 or 2 times.

Carvedilol adverse reactions

1. Mental and nervous system: I often see mild dizziness, headache, and fatigue, especially in the early stage of treatment; rare depression, sleep disturbance, and paresthesia.

2. Cardiovascular system: treatment of bradycardia, orthostatic hypotension, rarely causes syncope; rare peripheral circulation disorders (cold limbs), edema and angina; rare intermittent claudication or Raynaud Symptoms worsen in some patients; atrioventricular block and increased heart failure can occur in individual patients.

3. Respiratory system: occasionally induces the onset of asthma or dyspnea in patients, rare nasal congestion.

4. Digestive system: rare constipation and vomiting; occasional gastrointestinal discomfort (such as abdominal pain, diarrhea, nausea, etc.) and elevated serum aminotransferases.

5. Urogenital system: rare dysuria, sexual dysfunction; patients with heart failure and diffuse vascular disease and / or renal insufficiency may further aggravate renal function damage, and renal failure may occur in individual cases.

6. Skin: Rare allergic rashes, individual patients may have urticaria, pruritus, lichen planus-like skin reactions. Psoriasis-like skin damage may occur or exacerbate the original condition.

7. Eyes: can cause dry eyes; rare visual disturbances and eye irritation.

8. Blood: occasionally thrombocytopenia, leukopenia, etc.

9. Metabolic / endocrine system: Due to the characteristics of -adrenergic blockers, this drug can cause clinical symptoms in patients with recessive diabetes, or worsen the condition of patients with existing diabetes, and inhibit the reverse glucose regulation mechanism. Patients with heart failure occasionally gain weight and hypercholesterolemia.

10. Other: Occasionally pain in the extremities, rare dry mouth.

Carvedilone notes

Patients with NYHA class IV decompensated heart failure, asthma, COPD with bronchospasm, liver and kidney dysfunction, to degree atrioventricular block, heart rate less than 50 beats per minute, sick sinus syndrome, etc. are disabled; generally need For long-term application, the treatment cannot be stopped suddenly, but it should be gradually reduced.