What Is Cefotaxime Sodium?
Cefotaxime sodium is a third-generation semi-synthetic cephalosporin, which is not as effective on gram-positive bacteria as cefazolin. Enterococci are resistant to this product, are ineffective against penicillin-resistant pneumococcus, and are negative for gram The bacteria have strong bactericidal activity, and have stronger antibacterial effect on Escherichia coli, influenzae bacillus, pneumoniae, proteus mirabilis, and salmonella than cefoperazone, weak or resistant to fragile Bacteroides, aeruginosa, cloaca Enterobacter is not sensitive to this product.
Basic Information
- Drug Name
- Cefotaxime Sodium
- Alias
- Cefotaxime
- Foreign name
- CefotaximeSodium (Claforan)
- Whether prescription drugs
- prescription
- Athletes use with caution
- Use with caution
Cefotaxime sodium indication
- It is used for infections in the respiratory tract, urinary tract, bones and joints, skin and soft tissues, abdominal cavity, biliary tract, digestive tract, facial features, genitals and other parts caused by sensitive bacteria. It is also effective for infections caused by burns, trauma, sepsis, and central infections.
Clinical application of cefotaxime sodium
- Adults: General infection, 1g each time, once every 12 hours; Moderate and severe infections, 1 to 2g each time, every 8 hours; Severe infections such as sepsis, 2g each time, every 6 to 8 hours. Gonorrhea, intramuscular injection 1g (only once). Children (1 month to 12 years old): 50 to 180 mg / kg daily, divided into 4 to 6 times. Renal insufficiency: creatinine clearance <20ml / min, the dosage is halved.
Cefotaxime sodium adverse reactions
- Allergic reactions can cause rashes, fever, and itching. Appetite deficiency, nausea, vomiting, and diarrhea appear in the digestive system. Abnormal liver function. Transient blood urea nitrogen and creatinine increase. Occasionally white blood cells, neutrophils, thrombocytopenia, and eosinophilia increased. Long-term medication can cause secondary infections such as candidiasis and pseudomembranous enteritis.
Cefotaxime sodium precautions
- Use with caution in patients with colitis. Those who are allergic to penicillin and allergies, and those with severe renal insufficiency should be used with caution. Long-term administration in large quantities can cause renal impairment. Long-term application can cause dysbiosis and even secondary infection.
Cefotaxime sodium contraindications
- Those who are allergic to cephalosporin antibiotics are prohibited.
Cefotaxime sodium drug interactions
- Combined with gentamicin or tobramycin, it has a synergistic effect on Pseudomonas aeruginosa; combined with amikacin, it has a synergistic effect on E. coli and Klebsiella pneumoniae; with aminoglycosides and other cephalosporins The use of bacteriocin or strong diuretics may increase renal toxicity; combined with probenecid, it can inhibit excretion of this product in the kidney, increase blood concentration and prolong plasma half-life.
- Note: The above content is only for introduction, the drug use must be carried out by a regular hospital under the guidance of a doctor.