What Is Citalopram Withdrawal?

Citalopram hydrobromide oral solution is an antidepressant and is a bicyclic hydrogenated phthaloline derivative.

Citalopram hydrobromide oral solution

Citalopram hydrobromide oral solution is an antidepressant and is a bicyclic hydrogenated phthaloline derivative.

Dosage form

Oral solution

Drug type

chemical

Specifications

10ml: 20mg (based on citalopram)

Various types of depression.

Oral, adult: 20mg 60mg once a day. Starting from 20 mg daily, it can be increased to 60 mg, which is the maximum daily dose, according to the severity of the disease and the patient's response. Increments need to be spaced 2-3 weeks apart. It usually takes 2-3 weeks for treatment to be effective. To prevent relapse, treatment lasts at least 6 months. Withdrawal symptoms have not been reported in clinical trials, but serotonin reuptake inhibitors (SSRI) may have withdrawal symptoms, so it takes a weekly stepwise reduction before discontinuation. For elderly patients over 65 years of age and patients with liver damage, the dose is halved. The usual dose is 10-30 mg daily, starting from 10 mg daily. The recommended daily dose is 20 mg daily and the maximum daily dose is 40 mg.

Citalopram is an antidepressant and is a bicyclic hydrogenated phthalate derivative. The antidepressant mechanism of citalopram may be related to the inhibition of 5-HT reuptake by central nervous system neurons, thereby enhancing the function of central serotoninergic nerves. In vitro tests and animal tests suggest that citalopram is a highly selective 5-HT reuptake inhibitor, which has less effect on the reuptake of norepinephrine and dopamine. Rats were given citalopram for 14 days, and the effect of inhibiting 5-HT uptake was not tolerated. Citalopram is a racemate, and its inhibitory effect on 5-HT reuptake is mainly exerted by its (S) -enantiomer. Citalopram on 5-HT1A, 5-HT2A, D1 receptor, D2 receptor, 1 receptor, 2 receptor, receptor, H1 receptor, GABA