What Is Dextromethorphan Hydrobromide?

White or almost white crystalline powder, tasteless or slightly bitter, soluble in water, ethanol, insoluble in ether. Melting point is about 125 ° C.

Chinese name: Dextromethorphan hydrobromide
Foreign name: Dextromethorphan
Alias: Safin, Dextran

Whether prescription drugs: no
Dosage form: Tablets, syrups
Whether to include health insurance: Yes

Dextromethorphan hydrobromide

White or almost white crystalline powder, tasteless or slightly bitter, soluble in water, ethanol, insoluble in ether. Melting point is about 125 ° C.

Pharmacology and application of dextromethorphan hydrobromide

This product is the d-isomer of morphine levoramyl methyl ether, which exerts a central antitussive effect by inhibiting the medullary cough center. Its antitussive strength is equivalent to or slightly stronger than that of codeine. No analgesic effect, long-term application without tolerance and addiction. The therapeutic dose does not inhibit breathing. Oral absorption is good, it takes effect for 15-30 minutes, and the effect can be maintained for 3-6 hours. The concentration of the protodrug in plasma is very low, and its main active metabolite, 3-methoxymorphinane, is high in plasma, with t _1/2 of 5 hours. It is mainly used for dry cough. It is suitable for cough when cold, acute or chronic bronchitis, bronchial asthma, sore throat, tuberculosis and other upper respiratory tract infections.

Dextromethorphan hydrobromide usage

Oral, 15 ~ 30 mg each time, 3 ~ 4 times a day.

Dextromethorphan hydrobromide note

Occasionally dizziness, mild drowsiness, dry mouth, constipation and other side effects, pregnant women and patients with sputum should be used with caution. Women within 3 months of pregnancy and those with a history of mental illness are prohibited. Do not overdose, it should not exceed 8 tablets (120mg) within 24 hours.

Dextromethorphan hydrobromide drug interactions

1. When used in combination with a monoamine oxidase inhibitor, it can cause high fever, coma, and even death.

2. Do not use with antidepressants.

3. It should not be used in combination with ethanol and other central nervous system inhibitory drugs, because it can enhance the inhibitory effect on the central nervous system.