What Is Diltiazem HCl?

This product can effectively expand the epicardial and subendocardial coronary arteries, alleviate spontaneous angina pectoris or angina pectoris caused by ergometrine-induced coronary spasm; slow down heart rate and blood pressure, reduce myocardial oxygen demand, increase Exercise tolerance and relieve exertional angina. This product can relax vascular smooth muscles, reduce the resistance of surrounding blood vessels, and lower blood pressure; the magnitude of blood pressure reduction is related to the degree of hypertension, and those with normal blood pressure only slightly reduce blood pressure. This product has a negative muscle effect and can slow the conduction of the sinoatrial node and the atrioventricular node.

Diltiazem hydrochloride

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This product can effectively expand the epicardial and subendocardial coronary arteries, alleviate spontaneous angina pectoris or angina pectoris caused by ergometrine-induced coronary spasm; slow down heart rate and blood pressure, reduce myocardial oxygen demand, increase Exercise tolerance and relieve exertional angina. This product can relax vascular smooth muscles, reduce the resistance of surrounding blood vessels, and lower blood pressure; the magnitude of blood pressure reduction is related to the degree of hypertension, and those with normal blood pressure only slightly reduce blood pressure. This product has a negative muscle effect and can slow the conduction of the sinoatrial node and the atrioventricular node.

Chinese name

Diltiazem hydrochloride

Foreign name

Diltiazem Hydrochloride

Drug name

Diltiazem hydrochloride

Raw material unit

Shanghai Huyuan Pharmaceutical Co., Ltd.

[Drug name]: Diltiazem hydrochloride

[Common name]: Diltiazem hydrochloride [National Medical Insurance Catalogue B].

[Raw material unit]: Shanghai Huyuan Pharmaceutical Co., Ltd.

[Preparation unit]: Tanabe Pharmaceutical Co., Ltd., Synthelabo Groupe, PIRAMAL INDIA LIMITED, Industries Chimiques Auxiliaires et de Synthèse

[English name]: Diltiazem Hydrochloride.

[Chemical name]: cis-(+)-5-[(2-dimethylamino) ethyl] -2- (4-methoxyphenyl) -3-acetoxy-2,3-dihydro- 1,5-phenylpropylthiothiazepine-4 (5H) -one hydrochloride.

[Molecular formula]: C22H26N2O4S · HCL.

[Molecular weight]: 450.99.

[CAS number]: 33286-22-5.

[Other names]: Tian Erxin, thiazepine, Hexin Shuang, Tierding, Hebei Shuang, Dilson, Hu Erxing, etc.

[Specifications]: Tablets / sustained release tablets: 30mg, 60mg, 90mg. Sustained-release capsule: 200mg / capsule. Powder injection: 10mg / branch, 50mg / branch.

[Indications]: Hypertension, fatty cardiomyopathy, angina pectoris caused by coronary artery spasm, and labor-type angina pectoris.

Indications of diltiazem hydrochloride

1. Angina pectoris and exertional angina due to coronary spasm. 2. hypertension. [Chemical composition] The main ingredients and chemical name of this product are: cis-(+)-5-[(2-dimethylamino) ethyl] -2- (4-methoxyphenyl) -3-acetoxy -2,3-dihydro-1,5-benzothiazepine-4 (5H) -one hydrochloride. Molecular formula: C22H26N2O4S · HCl, molecular weight: 450.99.

Pharmacological effects of diltiazem hydrochloride

1 Pharmacology This product is a calcium ion channel blocker, its effect is related to the inhibition of calcium ion influx during depolarization of myocardium and vascular smooth muscle.

2 Toxicological effects of carcinogenic, mutagenic and reproductive toxicity have been reported in rats taking this product for 24 months, and mice taking this product for 21 months have not found carcinogenic effects. No mutagenic effect was found in in vitro bacterial experiments. Animal experiments have confirmed that this product has no significant effect on fertility.

Diltiazem hydrochloride drug interactions

1 -blockers: Studies have shown that diltiazem hydrochloride and -blockers are well tolerated in combination, but data are insufficient in patients with left ventricular dysfunction and conduction dysfunction. This product can increase the bioavailability of propranolol by nearly 50%, so the dose of propranolol needs to be adjusted when starting or stopping the combination of two drugs.

2 Cimetidine: Because the inhibition of cytochrome P450 oxidase affects the first-pass metabolism of this product, it can significantly increase the peak blood concentration of this product and the area under the curve at the time of drug administration. Ranitidine only slightly increased the blood concentration of this product.

3 Digoxin: There are reports that this product can increase the blood concentration of digoxin by 20%, but there are also reports that do not affect. Although the results are contradictory, the digoxin blood drug should be monitored when starting, adjusting and stopping the treatment of this product Concentration to avoid excessive or insufficient digoxin.

4 Anesthetic: It can inhibit myocardial contraction, conduction, and autonomy, and has vasodilator effect, which can have a synergistic effect with this product. Therefore, the dose must be carefully adjusted when the two drugs are combined.

5 This product can significantly increase the peak plasma concentrations of triazolam and midazolam and extend their elimination half-life.

6 After this product is combined with carbamazepine, the blood concentration of carbamazepine can be increased by 40-72% in some cases, causing toxicity.

7 It has been found in patients with heart and kidney transplants that when this product is combined with cyclosporine, the dose of cyclosporine should be reduced by 15-48% to ensure that the drug concentration of cyclosporine is the same as before the combination of this product. Cyclosporine plasma drug concentrations should be monitored when the two are combined, especially when starting, adjusting the dose, or stopping the use of this product. The effect of cyclosporin on the plasma drug concentration of this product is unknown.

8 The combination of this product with rifampicin can significantly reduce the plasma drug concentration and efficacy of this product.

Adverse reactions of diltiazem hydrochloride

Common adverse reactions: edema, headache, nausea, dizziness, rash, weakness. Rare adverse reactions (<1%): cardiovascular system: angina pectoris, arrhythmia, atrioventricular block, bradycardia, bundle branch block, congestive heart failure, abnormal electrocardiogram, hypotension, palpitations, syncope, Tachycardia and ventricular premature beats. Nervous system: dreaming, forgetting, depression, abnormal gait, hallucinations, insomnia, nervousness, paresthesia, personality change, lethargy, tremor. Digestive system: anorexia, constipation, diarrhea, taste disorders, indigestion, thirst, vomiting, weight gain, alkaline phosphatase, lactate dehydrogenase, aspartate aminotransferase, and alanine aminotransferase are slightly elevated. Skin: petechiae, light sensitivity, itching, hives. Other: amblyopia, elevated CPK, dry mouth, dyspnea, epistaxis, irritability, hyperglycemia, hyperuricemia, impotence, muscle cramps, nasal congestion, polyuria, increased nocturia, tinnitus, bone and joint pain, Hair loss, erythema polymorpha, extrapyramidal syndrome, gingival hyperplasia, hemolytic anemia, prolonged bleeding time, leukopenia, purpura, retinopathy, thrombocytopenia, exfoliative dermatitis.