What Is Docusate Sodium?

Docusate sodium is a chemical. Wetting and detergency.

Chinese name: Docusate sodium
Foreign name: Docusate Sodium Tablets

main ingredient: Docusate sodium
Indication: For chronic constipation.

Docusate Sodium Basic Information

Chinese name: Docusate sodium

English name: Docusate sodium; bis [3- [6,7,8-trimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl) methyl] -3,4-dihydro-1H-isoquinolin-2- ium-2-yl] propyl] butanedioate, dichloride

English alias: Chlorure de doxacurium [French]; BW-A938U; Cloruro de doxacurio [Spanish]; DOXACURIUM CHLORIDE; Nuromax;

CAS number: 106819-53-8

Molecular formula: C ₅₆ H ₇₈ Cl ₂ N ₂ O ₁₆

Molecular weight: 1106.13000

Exact mass: 1104.47000

PSA: 163.36000

LogP: 1.63540 ^[1]

Docusate sodium properties

This product is colorless or light yellow liquid. The density (25 ° C) is 1.02 to 1.08g / cm3. Flash point (open cup) 91 95 . The surface tension is (26 29) × 10-3N / m (0.1% solution). Soluble in water and organic solvents such as benzene and carbon tetrachloride. Wetting and detergency.

Docusate sodium calculated chemical data

1. Hydrophobic parameter calculation reference value (XlogP): None

2.Number of hydrogen bond donors: 0

3.Number of hydrogen bond acceptors: 18

4.Number of rotatable chemical bonds: 29

5.Number of tautomers: none

6. Topological molecular polar surface area 163

7.Number of heavy atoms: 76

8.Surface charge: 0

9.Complexity: 1540

10.Number of isotope atoms: 0

11. Determine the number of atomic stereocenters: 0

12. Uncertain number of atomic stereocenters: 4

13. Determine the number of chemical bond stereocenters: 0

14. Uncertain number of chemical bond stereocenters: 0

15. Number of covalent bond units: 3 ^[2]

Docusate sodium production method

5 ', 8'-Dimethoxy-N-methyl papaverine (I, 5', 8'-Dimethoxylaudanosine) is reacted with 3-iodopropanol, quaternized to form compound (II), and then succinyl chloride The reaction gives docuronium chloride. ^[3]

Docusate Sodium Related Drug Information

Docusate sodium classification name

Primary classification: Digestive system drugs Secondary classification: Diarrheal drugs

Docusate sodium drug English name

Docusate Sodium

Docusate sodium drug alias

Sodium dioctyl succinate, sodium octyl sulfonate, sodium succin octyl sulfonate, sodium succinate, dioctyl sulfosuccinate, sodium octyl sulfonate, Dioctyl Sodium, DioctylSodium Sulfosuccinate, Diocyl, Docusate, DSS, NatriiDioctylsulfosuccinas, Sulfosuceinate

Docusate sodium dosage form

Capsule: 50mg; 100mg. Solution: 1ml: 10mg. Syrup: 5ml: 20mg.

Pharmacological effects of docusate sodium

This medicine is a non-irritating laxative and is a surfactant. After oral administration, water and fatty substances are infiltrated into the feces in the intestine, thereby softening the feces.

Pharmacokinetics of Docusate Sodium

The drug is absorbed through the gastrointestinal tract after oral administration. 1 to 3 days after oral administration to play a role in the treatment of constipation. The drug is mainly excreted through the bile.

Docusate sodium indication

1. For people who have weak bowel movements (such as anal, rectal disease, or postoperative patients) 2. Used to soften stools to relieve constipation (foreign data). 3. For patients with heart disease and other serious diseases that may be complicated by defecation (foreign data).

Docusate sodium contraindications

1. Patients with nausea and vomiting. 2. Undiagnosed acute abdominal pain (especially with appendic inflammation symptoms). 3. Intestinal obstruction (especially caused by fecal impaction) (foreign data).

Docusate sodium precautions

1. Use with caution: patients whose bowel habits change suddenly and last 2 weeks (foreign data). 2. The impact of the drug on pregnancy: There are reports of hypomagnesemia in mothers and newborns caused by long-term use of this drug (100-200 mg a day) during pregnancy; US Drug and Food Administration (FDA) pregnancy safety of this drug Grade C. 3. The effect of the drug on breastfeeding: It is not clear whether this drug is secreted into milk, and it should be used with caution by breastfeeding women. 5. As a laxative, this drug should not be used continuously for more than 1 week. 2. It is suggested in the foreign data that the first dose should be added and then adjusted according to different individuals. 3. When taking the liquid preparation of this medicine, it should be taken with milk or juice to reduce throat irritation. 4. During the medication, if rectal bleeding or slow bowel movements occur, the drug should be discontinued. 5. Overdose of this medicine can cause thirst, abdominal pain, vomiting, edema, bone pain, water and electrolyte imbalance, hypoalbuminemia, and syndromes that mimic colitis. 6. Storage method: Store at room temperature.

Docusate sodium adverse reactions

1. Digestive tract: can cause stomach cramps, nausea, diarrhea, irritation of the pharynx, and bitter taste in the mouth. 2. Liver: This medicine has certain liver toxicity. 3. Skin: A rash may appear.

Docusate sodium dosage

Adult regular dose: Oral administration: 50 240mg a day, dividedly. Children's regular dose: oral administration: 10 to 40 mg per day for children under 3 years old.

Docusate sodium drug interactions

1. This medicine can promote the absorption of mineral oil and the uptake of liver cells, leading to inflammation of the intestinal mucosa, liver, spleen, and lymph nodes, so the combination is prohibited. 2. When used in combination with demer heptanol and droperidol, it can increase the risk of cardiac adverse reactions (such as causing prolonged QT interval, apical torsional ventricular tachycardia, cardiac arrest). ^[4]