What Is Hyaluronan Gel?

Hyaluronic acid gel is a natural transparent polysaccharide, which is a linear high molecular polysaccharide composed of gluconic acid-N-glucosamine acetate as a disaccharide molecular unit.

Hyaluronic acid gel is a natural transparent polysaccharide.

The production process and technology of hyaluronic acid gel determine the quality difference, so the products produced by the correct source must have the therapeutic effect in use. Generally speaking, there are three ways to refine:

Hyaluronic acid animal tissue

The main raw materials are cockscomb and bull's eye vitreous. The raw materials are degreased and dehydrated with acetone or ethanol, soaked with distilled water, filtered, and then treated with an aqueous solution of sodium chloride and chloroform, and then mixed with trypsin to obtain a mixed solution, and finally treated with an ion exchanger and purified to obtain a refined transparent Acid gel. The extraction rate of this method is very low, only about 1%, and the separation process is complicated. As a result, the hyaluronic acid gel is expensive, reaching 5,000 USD / kg, which limits the large-scale use in cosmetics.

Hyaluronic acid microbial fermentation

Glucose was used as a carbon source fermentation broth. Fermentation in the culture medium for 48 hours. After the fermentation, the mycelia and impurities are removed by filtration, and then a simple operation such as an alcohol precipitation method is used to obtain a high-purity product. The advantage of hyaluronic acid gel produced by fermentation is that the molecular weight can be set according to the product design. The key to the fermentation method is the choice of strains. Currently, streptococcus and lactococci are mostly used.

Hyaluronic acid gel chemical synthesis

Adopt natural enzyme polymerization reaction; firstly use polysaccharide polymer to synthesize "hyaluronic acid oxazepine derivative", then add hydrolytic enzyme to make a complex of derivative and enzyme, and finally react at 90 degrees Celsius Hyaluronic acid gel is synthesized by removing enzymes from the solution. The artificial synthesis method can greatly reduce the manufacturing cost of hyaluronic acid, but the structure is less refined.

The difference between hyaluronic acid gel

It is also a product of hyaluronic acid gel, because of the difference in raw material source and manufacturing technology, it has a significant impact on the effect. The concentration of the product cannot be used as a reference for product selection. The purity, molecular weight, and 3D structure will directly affect the water absorption effect of hyaluronic acid. Generally, the larger the molecular weight, the more complete the network structure and the best water absorption effect. Hygiene products and cosmetics are popular in the market, but the hyaluronic acid gels made by many manufacturers are cheap, but they may not be effective. Some oral hyaluronic acid gels have even been promoted. After absorption by the stomach and intestines, they will be broken down into small units of sugars and amino acids. They must still be recovered in the skin and scabby tissues through restoration steps such as autosynthesis. It must also be discounted.