What Is Hydantoin?

Hydantoin, Hydantoin, molecular formula C3H4N2O2, molecular weight 100.08. Is a chemical, mainly used in chemical, pharmaceutical, textile, biochemical and other fields.

[Chinese name] Hein; hydantoin; 2,4-imidazoline dione

[English name] Hydantoin

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CAS number: 461-72-3

MDL number: MFCD00005259

EINECS number: 207-313-3

RTECS number: MT8210000

BRN number: 110598

PubChem number: 24878236 ^[1]

Melting point (ºC): 218-220

Properties: Those crystallized in methanol are colorless needle-like crystals, and those crystallized from water are colorless flake crystals.

Solubility: soluble in water (25 ° C, 39.7), methanol, ethanol, acetic acid, alkaline aqueous solution. ^[1]

Reproductive toxicity:

Oral TDLo for human women: after 1-39 days of pregnancy: 4140 mg / kg SEX / DURATION, abnormal development of urogenital system;

Oral TDLo in rats DOSE: 7-18 days after pregnancy: 144000 mg / kg SEX / DURATION, affecting neonatal survival index;

TDOS of mice via abdominal cavity: 11-13 days after pregnancy: 12gm / kgSEX / DURATION, fetal death, specific developmental abnormalities-craniofacial (including nose and tongue), cardiovascular (circulatory) system;

TDOS of mice via abdominal cavity: after 8-10 days of pregnancy: 9gm / kgSEX / DURATION, fetal central nervous system reproduction, musculoskeletal system abnormalities;

Mouse DOSE transabdominal TDLo: 8-10 days after pregnancy: 12gm / kgSEX / DURATION, abnormal fetal eye / ear development;

Mice dose transperitoneal TDLo: 8-10 days after pregnancy: 6gm / kg SEX / DURATION, fetal growth retardation. ^[1]

This substance may be harmful to the environment. Special attention should be given to water bodies.

1. Molar refractive index: 20.79

2. Molar volume (m ^{3 /} mol): 73.7

3. Isometric Zhang Rongrong (90.2K): 187.3

4. Surface tension (dyne / cm): 41.5

5. Polarizability (10 ^-24 cm ³ ): 8.24 ^[1]

1. Hydrophobic parameter calculation reference value (XlogP): None

2.Number of hydrogen-bonded donors: 2

3.Number of hydrogen bond acceptors: 2

4.Number of rotatable chemical bonds: 0

5.Number of tautomers: 8

6. Topological molecular polar surface area 58.2

7.Number of heavy atoms: 7

8.Surface charge: 0

9.Complexity: 120

10.Number of isotope atoms: 0

11. Determine the number of atomic stereocenters: 0

12. Uncertain number of atomic stereocenters: 0

13. Determine the number of chemical bond stereocenters: 0

14. Uncertain number of chemical bond stereocenters: 0

15. Number of covalent bond units: 1 ^[1]

Use and store according to specifications without decomposition and avoid contact with oxides.

(1) Formaldehyde, hydrocyanic acid, and ammonia are used as raw materials to obtain a solution reaction and then react with carbon dioxide;

(2) Obtained by the reaction of potassium cyanate and aminoacetic acid;

(3) Obtained by the reaction of ethyl aminoamino acid and potassium cyanate;

(4) It is obtained by the condensation of urea and glycolic acid. ^[1]

Store in a sealed place in a ventilated, dry place and avoid contact with other oxides.

1. A raw material for preparing a hydantoin derivative.

2. For organic synthesis

3. Application in chemical, pharmaceutical, textile, biochemical and other fields. ^[1]

I. Emergency Response to Leakage

Cut off the fire. Wear self-contained breathing apparatus and general fire protective clothing. Stop leaks while ensuring safety. Water spray reduces evaporation. Absorb with sand or other non-combustible adsorbent. It is then transported to an open area for burial, evaporation, or incineration. If there is a large amount of leakage, use a dike to contain it, and then collect, transfer, recycle or harmlessly dispose of it.

Second, protective measures

Respiratory protection: When the concentration in the air is high, you should wear a gas mask. It is recommended to wear a self-contained breathing apparatus for emergency or rescue.

Eye protection: Wear chemical safety protective glasses.

Body protection: Wear antistatic work clothes.

Hand protection: Wear protective gloves.

Others: Smoking is strictly prohibited on the job site. Avoid prolonged repeated exposure.

Third, first aid measures

Skin contact: Remove contaminated clothing and rinse thoroughly with soap and water.

Eye contact: Open the upper and lower eyelids immediately and rinse with running water for 15 minutes. Seek medical attention.

Inhalation: Remove from the scene to fresh air. Difficulty breathing to give oxygen. Once breathing stops, begin CPR immediately. Seek medical attention.

Ingestion: If you take it by mistake, rinse your mouth with water, drink plenty of warm water, induce vomiting, and consult a doctor immediately. ^[1]

Safety identification: S24 / 25. ^[1]