What Is Itopride?

Etopril is a chemical drug with a molecular formula of C ₂₀ H ₂₆ N ₂ O ₄ and a molecular weight of 358.4314. Oral absorption is rapid, suitable for various symptoms caused by functional dyspepsia.

Chinese name: Itobilli
Foreign name: Itopride

Chinese alias: Etopril
Molecular formula: C20H26N2O4

Itobili Basic Information

Chinese name

Chinese alias: Etopril; Retazoline; N- [4- [2- (Dimethylamino) ethoxy] benzyl] -3,4-dimethoxybenzamide

English name: Itopride

Itobilli

English alias: N- {4- [2- (Dimethylamino) ethoxy] benzyl} -3,4-dimethoxybenzamide

CAS number: 122898-67-3

Molecular formula: C ₂₀ H ₂₆ N ₂ O ₄

Molecular weight: 358.4314

Etopril pharmacological effects

This product has the dual effects of dopamine D2 receptor block and acetylcholinesterase inhibition. It stimulates gastric and duodenal movement by stimulating endogenous acetylcholine release and inhibiting its hydrolysis, promotes gastric emptying, and has moderate emesis effect.

Itobili pharmacokinetics

Oral absorption is rapid, Tmax is about 30min, and t1 / 2 is about 6h. 4% to 5% of the original and 75% of the metabolites are excreted through the urine. Animal tests show that the drug is mainly distributed in the liver, gallbladder, kidney, brain, and digestive system, and the central system is rarely distributed.

Itobili indications

Gastrointestinal prokinetic drugs are suitable for various symptoms caused by functional indigestion, such as epigastric discomfort, postprandial fullness, loss of appetite, nausea, and vomiting.

Ito must use the amount of law

oral. Adults take 50mg once a day, 3 times a day, before meals.

Etopril adverse reactions

Digestive system may occasionally appear diarrhea, abdominal pain, constipation, increased saliva secretion. The neuropsychiatric system occasionally has headaches and sleep disorders. Leukopenia is occasionally seen in the blood system (it should be discontinued). Allergic symptoms: rash, fever, itching, etc. Occasionally, blood urea nitrogen appears, and creatinine value increases. You can also see back pain, fatigue, numb fingers, and shaking hands.

Itobili precautions

(1) This product can enhance the effect of acetylcholine, especially in elderly patients, which are prone to adverse reactions, and should be paid attention to when using it. Symptoms of hyperacetylation with hyperacetylation are overdose, blurred vision, abdominal pain, diarrhea, severe hypokalemia, shortness of breath, wheezing, chest tightness, increased saliva and bronchial secretion. Can be rescued with an appropriate amount of atropine.

(2) Pregnant women, breastfeeding women, and elderly patients should be used with caution, and children should not use it.