What Is Meloxicam?
Meloxicam is an enol nonsteroidal anti-inflammatory drug with anti-inflammatory, analgesic and antipyretic effects. The selective inhibition of cyclooxygenase-2 (COX-2) has a weak inhibitory effect on cyclooxygenase-1, so there are fewer adverse reactions such as the digestive system.
Basic Information
- Chinese name
- Meloxicam
- Foreign name
- Meloxicam
- Pinyin
- Meiluoxikang
- Molecular formula
- C14H13N3O4S2
- Molecular weight
- 351.40
- Character
- Light yellow or yellow powder
- Indication
- Symptoms of rheumatoid arthritis
- Store
- Sealed and sealed
Meloxicam Indication
- It is suitable for the symptomatic treatment of rheumatoid arthritis and osteoarthritis, such as pain, swelling and inflammation of soft tissues, traumatic pain and pain after surgery.
Meloxicam clinical application
- Oral
- Osteoarthritis is 7.5mg a day, and it is taken once, and the maximum daily dose is 15mg;
- Ankylosing spondylitis and rheumatoid arthritis 15mg a day, divided into two doses, can also be reduced to 7.5mg a day. The maximum daily dose is 15 mg for adults and 7.5 mg for seniors.
- 2. Rectal administration
- Osteoarthritis 7.5 15mg, stuffed into the anus before going to bed;
- Ankylosing spondylitis and rheumatoid arthritis 15mg or 7.5mg, stuffed into the anus before going to bed. 7.5mg for the elderly, stuffed into the anus before going to bed.
- 3. Other
- Not recommended for children under 15 years.
Meloxicam adverse reactions
- Including gastrointestinal reactions (common indigestion, nausea, abdominal pain or diarrhea; rare ulcers, bleeding or perforation); anemia, leukopenia or thrombocytopenia, itching, rash; stomatitis; slight dizziness, headache; edema, elevated blood pressure, etc. Elevated liver enzymes were common (10%), and occasional renal damage (0.4%). Most of them disappeared after discontinuation.
Meloxicam precautions
- Patients with renal failure on dialysis should not exceed 7.5 mg / day. Use with caution in patients who have a history of gastrointestinal disease and are currently using anticoagulants.
Meloxicam contraindications
- The following conditions are prohibited: patients with asthma, nasal polyps, angioedema or urticaria after using aspirin or other non-steroidal anti-inflammatory drugs; patients with active peptic ulcer, severe liver dysfunction, and severe renal function in non-dialysis patients Patients with insufficiency; patients with gastrointestinal bleeding, cerebral hemorrhage or other bleeding disorders; patients with severe uncontrolled heart failure; children and adolescents younger than 15 years, pregnant or breastfeeding.
Meloxicam drug interactions
- 1. Combined with methotrexate to increase the blood toxicity of methotrexate.
- 2. Combination of oral anticoagulants and thrombolytic agents may increase bleeding.
- 3. It can reduce the antihypertensive and diuretic effects of -adrenoceptor blockers, angiotensin-converting enzyme inhibitors, diuretics (except furosemide), and thiazide drugs.
- 4. Combined with potassium-preserving diuretics to reduce diuretic effects, which may cause hyperkalemia or toxic kidney damage.
- 5. Combined with cyclosporine, the risk of cyclosporine poisoning increases.
- 6. Combined with levofloxacin and ofloxacin, the risk of seizures increases.
- Note: The above content is only for introduction, the drug use must be carried out by a regular hospital under the guidance of a doctor.