Colorless liquid. It smells like pepper. Miscible with water, soluble in ethanol, ether, acetone and benzene. The boiling point of the 35% piperidine azeotropic solution is 92.8 ° C; pKa11.1; slightly more basic than pyridine. It forms a salt with an acid. Its chemical properties are similar to those of a secondary fatty amine. Can volatilize with steam. Used in pharmaceuticals, mainly piperidine hydrochloride and piperidine nitrate (flaky crystals, melting point 110 ° C). It is also used in other organic synthesis and as a curing agent for epoxy resins. Prepared from pyridine by hydrogenation. Has strong reduction. [1]
2.Used as a condensing agent and solvent in organic synthesis
3.Used as analytical reagent
4. Hexahydropyridine, also known as piperidine, is an intermediate of mepidolium, a plant growth regulator.
5. Piperidine, also known as hexahydropyridine, is an intermediate between the fungicide fenpropidin and the plant growth regulator mepiperium.
6. Piperidine is used in the manufacture of local anesthetics, analgesics, bactericides, wetting agents, epoxy resin curing agents, rubber vulcanization accelerators, etc.
7, used as intermediates in synthetic drugs, raw materials for rubber accelerators and epoxy resin curing agents. [198]
1. Acute toxicity:
Oral LD50 in rats: 50mg / kg; Percutaneous LD50 in rabbits: 320mg / kg; LC50 in mice: 6000mg / m3 / 2H;
2. Medium toxicity, strong irritant to eyes and skin and a booster. Small doses can stimulate sympathetic and parasympathetic ganglia, but large doses can inhibit it. Mistakes can cause weakness, nausea, salivation, dyspnea, muscle paralysis and suffocation. Poisoned animals show nausea, vomiting, salivation, dyspnea, increased heart rate, increased blood pressure, weakness, convulsions, and paralysis. Guinea pigs are skin-skinned and cause severe irritation. Instillation into rabbit eyes produces severe irritation with permanent corneal damage.
3. Acute toxicity
LD50: 400mg / kg (rat oral); 276mg / kg (rabbit percutaneous)
LC50: 6000mg / m 3 (inhaled in mice, 2h)
4.Irritating
Transdermal rabbit: 5mg (24h), severe irritation.
Rabbit eyes: 250g (24h), severe irritation. [199]
1.No data on ecological toxicity
2. Biodegradable MITI-I test, initial concentration of 100ppm, sludge concentration of 30ppm, 26.9% degradation after 2 weeks
3. No information on non-biodegradability [199]
1. Molar refractive index: 26.40
2. Molar volume (cm3 / mol): 102.4
3. Isometric Zhang Rong (90.2K): 233.0
4. Surface tension (dyne / cm): 26.7
5. Polarizability (10-24cm3): 10.46 [199]
1. Chemical properties are alkaline (pK a 11.1), and form salts with hydrochloric acid, hydrobromic acid, etc. Reacts with an acylating agent to form an N-acyl derivative. It reacts with a haloalkane to form an N-alkyl derivative, and further reacts to obtain an ammonium salt. Piperidine can be formed by catalytic oxidation or heating with concentrated sulfuric acid.
4. Polymerization hazards without polymerization [199]
Precautions for storage
Store in a cool, ventilated warehouse. Keep away from fire and heat sources. The storage temperature should not exceed 37 ° C. Keep the container sealed. It should be stored separately from oxidants, acids, and edible chemicals. Use explosion-proof lighting and ventilation facilities. Prohibit the use of spark-prone machinery and tools. The storage area should be equipped with spill emergency treatment equipment and suitable containment materials. [199]
Gas chromatography with reference to the Handbook of Analytical Chemistry (fourth volume, chromatographic analysis), Chemical Industry Press [2]
Maximum allowable concentration of harmful substances in the air of the former Soviet Union workshop 0.2mg / m 3 [pelf] [2]
S16Keep away from sources of ignition. Keep away from fire.
S26In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. After accidental contact with eyes, rinse immediately with plenty of water and seek medical advice.
S27Take off immediately all contaminated clothing. Remove your clothing as soon as it becomes contaminated.
S45In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) In case of accident or if you feel unwell, seek medical advice immediately (show the label if possible). [200]
