What Is Neomycin Sulfate?

Neomycin sulfate is an aminoglycoside antibiotic. This product has a good antibacterial effect on Enterobacteriaceae bacteria such as Staphylococcus (methicillin-sensitive strains), Corynebacterium, Escherichia coli, Klebsiella, Proteus, etc. Cocci and Enterococcus are poor in activity. Pseudomonas aeruginosa and anaerobic bacteria are resistant to this product. Bacteria have partial or complete cross-resistance to streptomycin, neomycin, kanamycin, and gentamicin. Neomycin systemic administration has significant nephrotoxicity and ototoxicity, so it is limited to oral or topical application.

Neomycin sulfate

Neomycin sulfate is a

Properties: This product is white or off-white powder; odorless; easy to attract moisture; This product is very soluble in water and almost insoluble in ethanol, ether, acetone or chloroform.

category:

Pharmacokinetics: Neomycin is rarely absorbed orally (approximately 3%), but large doses are taken orally for a long period of time. A considerable amount can be absorbed even when there is ulcer or inflammation in the intestinal mucosa, especially

for

1. Take about 10mg of the product, add 1ml of water to dissolve, add 2ml of hydrochloric acid solution (9 100), and heat in a water bath for 10 minutes, add 8ml of sodium hydroxide solution 2ml and 2% of acetylacetone aqueous solution 1ml, heat in a water bath After 5 minutes of cooling, add 1ml of p-dimethylaminobenzaldehyde test solution, which shows cherry red.

2. Take this product and neomycin standard product, and add water to make a solution containing 20mg per 1ml. According to the thin-layer chromatography (Appendix V B) test, draw 1 l of each of the two solutions, and point them on the same silica gel H thin-layer plate (0.25% of silica gel H, 0.25%)

Acidity: Take this product, add water to make a solution containing 0.1g per 1ml, and measure it according to law (Appendix VI H), the pH value should be 5.0 ~ 7.0.

Sulfate: Take about 0.16g of this product, weigh it accurately, add 100ml of water to dissolve it, add concentrated ammonia solution to adjust the pH to 11, add 10ml of barium chloride titration solution (0.1mol / L), and 5 Drop with

Accurately weigh an appropriate amount of the product, add sterilized water to make a solution containing about 1,000 units per 1ml, and determine according to the antibiotic microbiological test method (Appendix A). 1000 units of neomycin are equivalent to 1 mg of neomycin.

Neomycin sulfate tablets;

Neomycin sulfate eye drops;

Compound neomycin ointment

It is mainly used to treat trachoma and conjunctivitis.