What Is Norethindrone?
Norethisterone is a 19-desmethyltestosterone derivative and is an orally effective progestin. Its progestogen action is five times that of ethinylprogesterone, and it has mild androgenic and estrogen activity. Can inhibit the secretion of luteinizing hormone released by the hypothalamus, and act on the pituitary gland, reduce its sensitivity to luteinizing hormone, thereby blocking the release of gonadotropin and generating ovulation inhibition. Short-acting oral contraceptives.
Basic Information
- Chinese name
- Norethindrone
- English name
- norethindrone
- nickname
- Demethyldehydroprogesterone
- Chemical formula
- C20H26O2
- Melting point
- 202 208
- Water soluble
- Insoluble
- Exterior
- White or off-white crystalline powder
Norethindrone indication
- In addition to being used as an oral contraceptive, it can also be used to treat functional uterine bleeding, women's infertility, dysmenorrhea, amenorrhea, endometriosis, hyperendometrial hyperplasia, etc.
Norethindrone clinical application
- 1. Treatment of functional uterine bleeding: take 5mg every 8 hours for 3 consecutive days, once every 12 hours after hemostasis, and change to 2.5 3.75mg every 7 days for 2 weeks;
- 2. Dysmenorrhea, endometrial hyperplasia: Beginning on the 5th to 7th days of menstruation, once a day, 2.5mg each time, and even for 20 days.
Norethindrone adverse reactions
- A few women may have early pregnancy reactions such as nausea, vomiting, dizziness, fatigue, lethargy, irregular bleeding, amenorrhea, breast swelling, rash, etc., and usually disappear on their own.
Norethindrone considerations
- Smoking women who take contraceptive pills have more cardiovascular diseases, so women who take them should stop smoking, or women who smoke (especially those over 35 to 40 years old) should not take contraceptives. For long-term medication, pay attention to check liver function and pay special attention to breast examination. Breastfeeding women may lose milk after taking it, so it should be taken half a year after giving birth. Abortion should be taken on the 5th day of the first menstrual period.
Confinement of norethisterone
- Breastfeeding women, liver and kidney disease, uterine and breast tumors are forbidden.
Norethindrone drug interactions
- Equivalent to rifampicin, chloramphenicol, ampicillin, phenobarbital, sodium phenytoin, phumidone, clozazone, and acetaminophen can produce liver microsomal enzyme effect and accelerate the metabolism of norethindrone , Leading to contraceptive failure, increased incidence of breakthrough bleeding, should be paid attention to.
- Note: The above content is only for introduction, the drug use must be carried out by a regular hospital under the guidance of a doctor.