What Is Oxaprozin?

The main dosage form of oxaprozine is a tablet, which is a non-steroidal anti-inflammatory drug, which can reduce the production of an inflammatory medium, prostaglandin. With anti-inflammatory, analgesic, antipyretic effect.

Oxaprozine

This entry lacks an overview map . Supplementing related content makes the entry more complete and can be upgraded quickly. Come on!

The main dosage form of oxaprozine is a tablet, which is a nonsteroidal

[Drug name] Oxaprozin

[Drug alias] Neptunlong

[Molecular formula composition] 4,5-diphenyloxazole-2-propionic acid

[Specification] Tablet: 200 mg / tablet

This product is a new non-steroidal anti-inflammatory drug with anti-inflammatory, analgesic and antipyretic effects. It is an anti-inflammatory, analgesic and antipyretic effect by inhibiting cyclooxygenase and reducing the production of prostaglandin, an inflammatory mediator produced by arachidonic acid metabolism. It has a slight effect on the digestive tract and has long-lasting effects. In the acetic acid blood vessel permeability test and carrageenan foot swelling test in mice, the anti-inflammatory effect was stronger than that of aspirin and ibuprofen. In mice acetic acid, benzoquinone, and acetylcholine writhing tests, the analgesic effect is about than ibuprofen,

It is reported that Nordlen has positive clinical effects, wide indications, and ideal for all kinds of long-term pain relief. It can replace closed treatment of tenosynovitis, periarthritis, heel pain and strain. Shanghai Renji Hospital diagnosed 60 patients with rheumatoid arthritis by observation, 30 patients took Norderon and 30 patients took sodium diclofenac. The efficacy, side effects and withdrawal rate of the two drugs were compared. The results showed that the total effective rate in the Nordren group (80%) was slightly higher than that in the sodium diclofenac group (70%); the withdrawal rate was higher in the sodium diclofenac group (13.3%) than in the Nordren group (6.6%). ; Adverse reactions occurred, the diclofenac sodium group (14 people) was higher than the Nordren group (5 people). It shows that Norderon has a slightly higher efficacy than sodium diclofenac, but has significantly fewer side effects than sodium diclofenac. In particular, gastrointestinal adverse reactions were 10 sodium diclofenate, and only 3 were Nordlen. Norderon was used to treat 288 cases of rheumatoid arthritis in the First Affiliated Hospital of Beijing Medical University. The results were markedly effective in 129 cases (44.79%), effective in 121 cases (42.10%), ineffective in 38 cases (13.19%), and effective in more than 250 cases. The effective rate is 86.81%. Treatment of 429 cases of osteoarthritis, the effective rate was 84.62%. Treatment of 102 cases of rheumatoid arthritis, the results were significant in 60 cases (58.82%), 26 cases were effective (25.49%), the effective rate was 84.31%. In 52 cases of tenosynovitis, 23 cases were markedly effective, 16 cases were effective, 6 cases were improved, 7 cases were ineffective, 39 cases were effective, and the effective rate was 75%. Side effects were small, and 1 412 patients were treated. 146 cases (10.34%) of 158 adverse reactions occurred in digestive system. Among the 1 412 patients who took the drug for the longest period of 38 weeks, no serious symptoms such as melena, bleeding, dizziness, and syncope were seen. reaction. In 1993, the U.S. FDA first approved Nordlen as the first long-acting, low-toxicity non-steroidal anti-inflammatory analgesic for qd administration.

Healthy adult po, 400 mg / time, plasma concentration reached a peak after 3 to 4 hours, half-life is about 50 hours, po, 400 mg / d, qd or bid for 10 consecutive days, 4 to 6 d plasma concentration reached steady state . The blood concentration has nothing to do with the way of taking the medicine, and it has no effect before and after meals. The protein binding rate is as high as 99.5%. It is mainly excreted by the kidney in its original form and its metabolites. The metabolites are mainly oxapromazine glucuronide and oxaprozine benzene ring hydroxyl.

[Indications] Rheumatoid arthritis, rheumatoid arthritis, ankylosing spondylitis, periarthritis, neck and shoulder and wrist syndrome, gout and trauma, and anti-inflammatory and analgesia after surgery.

[Contraindications] Peptic ulcer, patients with severe liver and kidney disease, patients allergic to other non-steroidal anti-inflammatory drugs, patients with blood diseases, granulocytopenia, thrombocytopenia.

[Adverse reactions] This product has a low incidence of adverse reactions and mild symptoms, which can be tolerated by most patients. Occasionally mild stomach pain, upset, headache, drowsiness, disappeared after stopping the medicine.

medicine interactions

1 The combination of this product with aspirin may increase the toxicity of aspirin, because this product can replace salicylates bound to plasma proteins.

2 In the elderly and those with reduced renal function, the clearance of digoxin will be reduced, the blood concentration of the drug will increase, and its toxicity will increase.

3 When large doses are used to treat tumors, it affects the excretion of methotrexate, which increases the methotrexate blood concentration and causes poisoning.

4 Affects the antihypertensive effect of antihypertensive drugs (angiotensin-converting enzyme inhibitors and? Receptor inhibitor blockers).

5 Reduce diuretic and diuretic effects of diuretics.

[Usage and dosage] po, 400 mg / d, qd or bid, continuous medication for more than 1 week or as directed by a doctor, the maximum dose is 600 mg / d.

[Precautions] If abnormality is found after long-term use, appropriate measures such as reduction or withdrawal should be taken. Use caution when used with oral anticoagulants.

Production unit Shenzhen Haiwang Biological Engineering Co., Ltd. Changchun Company, approval number: Jiwei Medicine Zhunzi (1996) No. 121436

[Storage method] Keep away from light and sealed. Duration of use: three years