What Is Oxybutynin?

This product is a drug mainly acting on the parasympathetic nervous system. It has a strong smooth muscle antispasmodic effect, a strong analgesic effect, a weak anticholinergic effect and a local anesthetic effect. For the treatment of urgency, frequent urination, urinary incontinence, nocturnal enuresis and other diseases. It is most suitable for frequent urinary symptoms caused by cystitis, urethritis and recurrent urethral infection. It is also effective in treating pediatric enuresis.

Chinese name: Oxibutin
Foreign name: Oxybutynin

Alias: Urine
Molecular formula: C22H31NO3
CAS NO.: 5633-20-5

Oxybutin Basic Information

Chinese name

Chinese alias: urinary multidrug; 4- (diethylamino) but-2-yn-1-ylcyclohexyl (hydroxy) phenyl acetate

English name: oxybutynin

English alias: Oxybutinin; Cystrin; Oxybutyninum; Pollakisu; 4- (diethylamino) but-2-ynyl 2-cyclohexyl-2-hydroxy-2-phenylacetate; Oxybutynine; Oxybutynin; Oxytrol; Ditropan; Oxibutinina; Oxibutyninum;

CAS number: 5633-20-5

Molecular formula: C ₂₂ H ₃₁ NO ₃

Molecular weight: 357.48600

Exact mass: 357.23000

PSA: 49.77000

LogP: 3.34290

Physical and chemical properties of oxybutynin

Appearance and properties: white to off-white crystalline powder

Density: 1.097 g / cm ³

Melting point: 125-130ºC

Boiling point: 494.4ºC at 760 mmHg

Flash point: 252.8ºC

Oxybutin Safety Information

Customs code: 2922509090 ^[1]

Oxybutin ^[2] Molecular Structure

Oxybutyn pharmacological effects

This product is a tertiary amine antimuscarinic drug. The effect is similar to atropine. It also has a direct effect on smooth muscle. Its muscle relaxation is very strong, which can maximize the bladder capacity and minimize detrusor pressure.

Oxybutyn pharmacokinetics

The blood peak can be reached within 1 hour after taking the product orally. After extensive first-pass metabolism, the bioavailability is only 6%, and t1 / 2 is 2 to 3 hours. The product enters milk and penetrates the blood-cerebrospinal fluid barrier.

Oxybutin indications

Overactive bladder, frequent urination, urgency, neurogenic urinary incontinence, spontaneous detrusor instability, and nocturnal enuresis.

Oxybutyn contraindications

Those who are allergic to this medicine;

Glaucoma patients;

Persons with partial or complete gastrointestinal obstruction, paralytic intestinal obstruction;

When intestinal tension is lacking in elderly or weak patients;

Patients with reflux esophagitis;

Patients with myasthenia gravis;

Patients with obstructive urethral disease;

People with unstable cardiovascular function during bleeding period.

Oxybutyn notes

Use with caution: Patients with arrhythmia; Patients with liver disease; Patients with kidney disease; All patients with autonomic nervous disease; Patients with peptic esophagitis with hiatal hernia; Patients after ileum and colostomy; Patients with congestive heart failure; Patients with coronary heart disease; Hypertension patients; Hyperthyroidism patients; Prostatic hyperplasia; Children under 5 years old.

This medicine can cause symptoms such as blurred vision, drowsiness, etc. Drivers, machine operators, aerial workers and personnel engaged in dangerous work should pay attention when using this medicine.

Overdose can cause poisoning, mainly antimuscarinic effects, manifested as drowsiness, hallucinations, dilated pupils, urinary retention and ectopic ventricular rhythm. If the above situation occurs, the drug should be stopped immediately and treated symptomatically.

Patients with infection should use corresponding antibacterial drugs.

In patients with ulcerative colitis, large doses of this drug may inhibit intestinal motility and produce paralytic intestinal obstruction. Pregnancy class C. Banned for pregnant women and children under 5 years.

Oxybutyn adverse reactions

Dry mouth, flushed skin, less sweat, poor gastrointestinal motility, constipation, gastric-esophageal reflux, and difficulty urinating. Poisoning reactions above 2mg may include excessive heart rate, excitement, restlessness, convulsions, hallucinations, unconsciousness, etc.

Animal tests have confirmed that the product has reproductive toxicity when used in high doses.

Oxybutyn dosage

Adults: The usual oral dosage is 5mg, 2 to 3 times a day, and if necessary, it can be increased to 5mg, 4 times a day. The elderly begin to give 2.5 to 3 mg twice daily, if necessary and tolerated, it can be increased to 5 mg twice daily.

Children older than 5 years: Start oral 2.5 ~ 3mg, 2 times a day, if necessary, it can be increased to 5mg, 2 ~ 3 times a day. If used for nocturnal enuresis, the last dose can be administered before bedtime. ^[3]